Beacon Virtua: A Virtual Reality Simulation Detailing the Recent and Shipwreck History of Beacon Island, Western Australia

Beacon Virtua is a project to document and virtually preserve a historically significant offshore island as a virtual reality experience. In 1629, survivors of the wreck of VOC ship Batavia took refuge on Beacon Island, Western Australia, followed by a mutiny and massacre. In the 1950s the island became the base of a successful fishing industry, and in 1963 human remains from Batavia were located. The fishing community has recently been moved off the island to protect and preserve the site and allow a thorough archaeological investigation of the island. Beacon Virtua exposes users to the history of both the shipwreck survivors and the fishing community. The project uses the virtual environment development software Unity to present a simulation of the island, with 3D models of buildings and jetties, photogrammetric 3D reconstructions of graves and other features, 360° photographic panoramas, and information on the history of the island. The experience has been made available on a wide range of different platforms including via a web-page, as part of an exhibition, and on head mounted displays (VR headsets). This chapter discusses the features included in Beacon Virtua, the storytelling techniques used in the simulation, the challenges encountered and solutions used during the project

Vaccination with Plasmodium knowlesi AMA1 Formulated in the Novel Adjuvant Co-Vaccine HT™ Protects against Blood-Stage Challenge in Rhesus Macaques

Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a leading blood stage vaccine candidate. Plasmodium knowlesi AMA1 (PkAMA1) was produced and purified using similar methodology as for clinical grade PfAMA1 yielding a pure, conformational intact protein. Combined with the adjuvant CoVaccine HT™, PkAMA1 was found to be highly immunogenic in rabbits and the efficacy of the PkAMA1 was subsequently tested in a rhesus macaque blood-stage challenge model. Six rhesus monkeys were vaccinated with PkAMA1 and a control group of 6 were vaccinated with PfAMA1. A total of 50 µg AMA1 was administered intramuscularly three times at 4 week intervals. One of six rhesus monkeys vaccinated with PkAMA1 was able to control parasitaemia, upon blood stage challenge with P. knowlesi H-strain. Four out of the remaining five showed a delay in parasite onset that correlated with functional antibody titres. In the PfAMA1 vaccinated control group, five out of six animals had to be treated with antimalarials 8 days after challenge; one animal did not become patent during the challenge period. Following a rest period, animals were boosted and challenged again. Four of the six rhesus monkeys vaccinated with PkAMA1 were able to control the parasitaemia, one had a delayed onset of parasitaemia and one animal was not protected, while all control animals required treatment. To confirm that the control of parasitaemia was AMA1-related, animals were allowed to recover, boosted and re-challenged with P. knowlesi Nuri strain. All control animals had to be treated with antimalarials by day 8, while five out of six PkAMA1 vaccinated animals were able to control parasitaemia. This study shows that: i) Yeast-expressed PkAMA1 can protect against blood stage challenge; ii) Functional antibody levels as measured by GIA correlated inversely with the day of onset and iii) GIA IC50 values correlated with estimated in vivo growth rates

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

<i>Batavia </i>shipwreck timbers reveal a key to Dutch success in 17th-century world trade

Ocean-going ships were key to rising maritime economies of the Early Modern period, and understanding how they were built is critical to grasp the challenges faced by shipwrights and merchant seafarers. Shipwreck timbers hold material evidence of the dynamic interplay of wood supplies, craftmanship, and evolving ship designs that helped shape the Early Modern world. Here we present the results of dendroarchaeological research carried out on Batavia’s wreck timbers, currently on display at the Western Australian Shipwrecks Museum in Fremantle. Built in Amsterdam in 1628 CE and wrecked on its maiden voyage in June 1629 CE in Western Australian waters, Batavia epitomises Dutch East India Company (Verenigde Oostindische Compagnie, or VOC) shipbuilding. In the 17th century, the VOC grew to become the first multinational trading enterprise, prompting the rise of the stock market and modern capitalism. Oak (Quercus sp.) was the preferred material for shipbuilding in northern and western Europe, and maritime nations struggled to ensure sufficient supplies to meet their needs and sustain their ever-growing mercantile fleets and networks. Our research illustrates the compatibility of dendrochronological studies with musealisation of shipwreck assemblages, and the results demonstrate that the VOC successfully coped with timber shortages in the early 17th century through diversification of timber sources (mainly Baltic region, Lübeck hinterland in northern Germany, and Lower Saxony in northwest Germany), allocation of sourcing regions to specific timber products (hull planks from the Baltic and Lübeck, framing elements from Lower Saxony), and skillful woodworking craftmanship (sapwood was removed from all timber elements). These strategies, combined with an innovative hull design and the use of wind-powered sawmills, allowed the Dutch to produce unprecedented numbers of ocean-going ships for long-distance voyaging and interregional trade in Asia, proving key to their success in 17(th)-century world trade

Pigments from the Zuiddorp (Zuytdorp) ship sculpture: Red, white and blue?

The Dutch East India Company ship Zuiddorp (also known as Zuytdorp) met its demise in 1712 at the base of steep cliffs along the Western Australian coast. Material from the shipwreck includes an extraordinary example of a caryatid herm from the ship's stern counter. A recent study of this sculpture and the pigments found on its surface demonstrates Zuiddorp's archaic stern construction and adornment, which is more of a late 17th-century, than an early 18th-century, Dutch Indiaman. This paper discusses the results of this study and emphasizes how the smallest pieces of evidence can broaden our understanding of contemporaneous regional Dutch East India Company shipbuilding practices. © Society for Post-Medieval Archaeology 2016

Report on ‘Mapping the old with the new: re-imaging the 1727 zeewijk shipwreck site with new recording technology’ project

In 1727 the Dutch United East India Company (Verenigde Oostindische Compagnie, or VOC) ship Zeewijk wrecked in the Pelsaert Group of the Houtman Abrolhos Islands.This report details the methodology, outputs and conclusions of a 2022 field survey conducted between 11 and 17 March 2022. The primary aim was to create a 3D record of the Zeewijk (1727) shipwreck site using photogrammetry. The work would allow for a critical assessment of Mr Hugh Edwards’ claim of finding the wreck of Aagtekerke (1726) on the same site as Zeewijk. It would also better visualise the site for research, management, and public interpretation purposes. The fieldwork successfully mapped the widely dispersed Zeewijk shipwreck site on the inner (inside lagoon) and outer reef (in the surf zone) using digital cameras and GPS positioning. It resulted in significant new findings allowing a re-evaluation of the total count of all iron cannon and anchors in the offshore reef, and inshore lagoon areas.This work, when combined with findings of the earlier ‘Roaring Forties Project’ (Paterson et al. 2019), and more recent research undertaken by the Western Australian (WA) Museum, provides convincing evidence that there is only one shipwreck on the Zeewijk site, and negates the hypothesis of two VOC shipwrecks present within the Pelsaert Group. The resulting updated corpus of high-resolution digital imagery, 3D models and site data will greatly facilitate future studies, public interpretation outputs and on-going site monitoring and management of this highly significant Dutch-Australian mutual heritage site. It is gratefully acknowledged that the field work was primarily funded by a grant from the Embassy of the Kingdom of the Netherlands (GCE-2019-03), with additional funding support provided through the WA Museum/Australian Government’s Underwater Cultural Heritage Program and Flinders University’s Maritime Archaeology Program. Transport, logistics and local knowledge to enable safe access to the Zeewijk site were provided by the Liddon family.GCE-2019-03Archaeological Heritage Managemen