593 research outputs found
Rauheitsmessung an pharmazeutischen tabletten mittels angularer speckle-korrelation
En este artículo se estudia la calidad del proceso de fabricación pastillas de distinto origen, entre los que se incluyen productos genéricos. El resultado fundamental es que, las marcas oficiales y sus respectivos genéricos, no son iguales desde el punto de vista de su acabado, lo cual repercute directamente en su eficacia.Eine vollsUindige Charakterisierung von pharmazeutischen Tabletten besteht nicht nur in der Analyse der chemischen Zusammensetzung, sondern auch in der Untersuchung der Fertigung der inneren Struktur und der OberfUichenstruktur. Ziel dieser Arbeit ist es, die OberfUichenrauheit von Tabletten an Originalpra• paraten und Generika mittels Angularer Speckle Korre• lation (ASK) zu bestimmen. Die Ergebnisse zeigen un terschiedliche Rauheitswerte bei Tabletten mit gleichem Wirkstoff bei verschiedenen Tragerstoffen. Berührungslose Speckle-Rauheitsmessung konnte eingesetzt werden, um die Regelung des Produktionsprozesses zu verbessern, z. B. wahrend die Tabletten aus Pulver gepresst werden. A complete characterization of pharmaceutical tablets requires not only the analysis of its chemical com• pounds, but also of its inner and surface structure manufacturing. The aim of this work is to determine the sur face roughness of original and generic tablets by means of angular speckle correlation (ASC). The results show different roughness properties between tablets with the same active ingredients, but with different excipients. Contactless speckle roughness measurements could be used to im• prove the control of the production process, e. g., when tablets are pressed from powder
Kaon physics with the KLOE detector
In this paper we discuss the recent finalized analyses by the KLOE experiment
at DANE: the CPT and Lorentz invariance test with entangled pairs, and the precision measurement of the branching fraction of
the decay . We also present the
status of an ongoing analysis aiming to precisely measure the mass
Heterogenized Pyridine-Substituted Cobalt(II) Phthalocyanine Yields Reduction of CO2 by Tuning the Electron Affinity of the Co Center
Conversion of CO2 to reduced products is a promising route to alleviate irreversible climate change. Here we report the synthesis of a Co-based phthalocyanine with pyridine moieties (CoPc-Pyr), which is supported on a carbon electrode and shows Faradaic efficiency ∼90% for CO at 490 mV of overpotential (-0.6 V vs reversible hydrogen electrode (RHE)). In addition, its catalytic activity at -0.7 V versus RHE surpasses other Co-based molecular and metal-organic framework catalysts for CO2 reduction at this bias. Density functional theory calculations show that pyridine moieties enhance CO2 adsorption and electron affinity of the Co center by an inductive effect, thus lowering the overpotential necessary for CO2 conversion. Our study shows that CoPc-Pyr reduces CO2 at lower overpotential and with higher activity than noble metal electrodes, such as silver
CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism
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Limit on the production of a new vector boson in , U with the KLOE experiment
The recent interest in a light gauge boson in the framework of an extra U(1)
symmetry motivates searches in the mass range below 1 GeV.
We present a search for such a particle, the dark photon, in , U based on 28 million
events collected at DANE
by the KLOE experiment. The production by initial-state radiation
compensates for a loss of sensitivity of previous KLOE , searches due to the small branching ratios in
the resonance region. We found no evidence for a signal and set a
limit at 90\% CL on the mixing strength between the photon and the dark photon,
, in the U mass range between and ~MeV. Above 700 MeV
this new limit is more stringent than previous ones.Comment: 6 pages, 9 figures, 1 table, submitted to Phys. Lett.
Measurement of the transition form factor with the KLOE detector
A measurement of the vector to pseudoscalar conversion decay with the KLOE experiment is presented. A sample of signal
events was selected from a data set of 1.7 fb of collisions at
collected at the DANE collider. These
events were used to obtain the first measurement of the transition form factor
and a new measurement of the branching ratio of the
decay: . The result improves
significantly on previous measurements and is in agreement with theoretical
predictions.Comment: 13 pages, 4 figures; matches published versio
Precision measurement of the Dalitz plot distribution with the KLOE detector
Using fb of data collected with
the KLOE detector at DANE, the Dalitz plot distribution for the decay is studied with the world's largest sample of events. The Dalitz plot density is parametrized as a polynomial
expansion up to cubic terms in the normalized dimensionless variables and
. The experiment is sensitive to all charge conjugation conserving terms of
the expansion, including a term. The statistical uncertainty of all
parameters is improved by a factor two with respect to earlier measurements.Comment: 11 pages, 9 figures, supplement: an ascii tabl
Search for dark Higgsstrahlung in e+ e- -> mu+ mu- and missing energy events with the KLOE experiment
We searched for evidence of a Higgsstrahlung process in a secluded sector,
leading to a final state with a dark photon U and a dark Higgs boson h', with
the KLOE detector at DAFNE. We investigated the case of h' lighter than U, with
U decaying into a muon pair and h' producing a missing energy signature. We
found no evidence of the process and set upper limits to its parameters in the
range 2m_mu<m_U<1000 MeV, m_h'<m_U.Comment: 16 pages, 7 figures, submitted to Physics Letters
Study of the a_0(980) meson via the radiative decay phi->eta pi^0 gamma with the KLOE detector
We have studied the phi->a_0(980) gamma process with the KLOE detector at the
Frascati phi-factory DAPhNE by detecting the phi->eta pi^0 gamma decays in the
final states with eta->gamma gamma and eta->pi^+ pi^- pi^0. We have measured
the branching ratios for both final states: Br(phi->eta pi^0 gamma)=(7.01 +/-
0.10 +/- 0.20)x10^-5 and (7.12 +/- 0.13 +/- 0.22)x10^-5 respectively. We have
also extracted the a_0(980) mass and its couplings to eta pi^0, K^+ K^-, and to
the phi meson from the fit of the eta pi^0 invariant mass distributions using
different phenomenological models.Comment: 17 pages, 6 figures, submitted to Physics Letters B. Corrected typos
in eq.
Precision measurement of and determination of the contribution to the muon anomaly with the KLOE detector
We have measured the ratio
, with the KLOE detector at DANE for a total integrated
luminosity of 240 pb. From this ratio we obtain the cross section
. From the cross section we determine the
pion form factor and the two-pion contribution to the muon anomaly
for GeV, = . This result confirms the
current discrepancy between the Standard Model calculation and the experimental
measurement of the muon anomaly.Comment: 18 pages, 8 figures, minor text corrections, one table added, version
to appear on Physics Letters
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