Connecting Carrier\u27s Liability for Loss or Damage to Shipments

Is a carrier liable for a shipment it did not receive? What is the situation when a carrier receives only part of the goods from the preceding carrier, or when it receives them all but in damaged condition? How is the carrier\u27s liability affected if the damage is latent or patent? Discussion of these questions will be limited to shipments in interstate commerce and in three basic areas: (1) carrier\u27s common law liability,1 (2) effect of federal enactments, and (3) establishment of a prima facie case

Elastic constants of 3-, 4- and 6-connected chiral and anti-chiral honeycombs subject to uniaxial in-plane loading

Finite Element models are developed for the in-plane linear elastic constants of a family of honeycombs comprising arrays of cylinders connected by ligaments. Honeycombs having cylinders with 3, 4 and 6 ligaments attached to them are considered, with two possible configurations explored for each of the 3- (trichiral and anti-trichiral) and 4- (tetrachiral and anti-tetrachiral) connected systems. Honeycombs for each configuration have been manufactured using rapid prototyping and subsequently characterised for mechanical properties through in-plane uniaxial loading to verify the models. An interesting consequence of the family of 'chiral' honeycombs presented here is the ability to produce negative Poisson's ratio (auxetic) response. The deformation mechanisms responsible for auxetic functionality in such honeycombs are discussed

Solving Defender-Attacker-Defender Models for Infrastructure Defense

In Operations Research, Computing, and Homeland Defense, R.K. Wood and R.F. Dell, editors, INFORMS, Hanover, MD, pp. 28-49.The article of record as published may be located at http://dx.doi.org10.1287/ics.2011.0047This paper (a) describes a defender-attacker-defender sequential game model (DAD) to plan defenses for an infrastructure system that will enhance that system's resilience against attacks for an intelligent adversary, (b) describes a realistic formulation of DAD for defending a transportation network, (c) develops a decomposition algorithm for solving this instance of DAD and others, and (d) demonstrates the solution of a small transportation-network example. A DAD model generally evaluates system operation through the solution of an optimization model, and the decomposition algorithm developed here requires only that this system-operation model be continuous and convex. For example, our transportation-network example incorporates a congestion model with a (convex) nonlinear objective function and linear constraints

Cubic Curves, Finite Geometry and Cryptography

Some geometry on non-singular cubic curves, mainly over finite fields, is surveyed. Such a curve has 9,3,1 or 0 points of inflexion, and cubic curves are classified accordingly. The group structure and the possible numbers of rational points are also surveyed. A possible strengthening of the security of elliptic curve cryptography is proposed using a `shared secret' related to the group law. Cubic curves are also used in a new way to construct sets of points having various combinatorial and geometric properties that are of particular interest in finite Desarguesian planes.Comment: This is a version of our article to appear in Acta Applicandae Mathematicae. In this version, we have corrected a sentence in the third paragraph. The final publication is available at springerlink.com at http://www.springerlink.com/content/xh85647871215644

'The drugs did for me what I couldn’t do for myself’: A qualitative exploration of the relationship between mental health and amphetamine-type stimulant (ATS) use

Substance use and mental ill health constitute a major public health burden, and a key global policy priority is to reduce illicit and other harmful substance use. Amphetamine-type stimulants (ATS) are the second most used class of illicit drugs and a range of mental health issues have been documented amongst users. This paper explores the relationship between mental health and ATS use, through a thematic analysis of qualitative interviews with n=18 current and former ATS users in England. The findings are presented by trajectory point of; (1) Initiation of ATS use; (2) continued and increased ATS use; and (3) decreased and remitted ATS use. This work helps to develop understanding around the complex and bidirectional relationship between ATS use and mental health. Many ATS users lead chaotic lives and engage in multiple risk behaviours; however, there is a need to better understand and conceptualise the dynamic interaction between different individual, social, environment and cultural factors that determine individuals’ mental health and substance use. There is no ‘one size fits all’ approach to prevention and treatment, and these findings highlight the need for more joined-up, tailored, and holistic approaches to intervention development

The rights of the child: are we creating a world in which all children are enabled to reach their full potential?

This chapter, through the lens of the UN Convention on the Rights of the Child, reviews whether we are actually creating world in which children’s development needs are recognized and met. The principle focus of the chapter is each child’s right to an education. In particular Articles 28 and 29 of the UNCRC are highlighted to provide a benchmark against which to consider education provision in multiple international contexts. Reference is made to the UN Millennium Declaration, the eight Millennium Development Goals and the UNICEF report “The State of the World’s Children 2016: A fair chance for every child” to enable examination of how a world fit for children is being achieved or not. From examination of the aforementioned reports, three imperatives emerge: economic, education and moral. These imperatives challenge the reader to consider how legislation and policy works towards or hinders the goal of creating a world in which all children are enabled to reach their full potential

Pyridoxamine Traps Intermediates in Lipid Peroxidation Reactions in Vivo: Evidence on the Role of Lipids in Chemical Modification of Protein and Development of Diabetic Complications

Maillard or browning reactions between reducing sugars and protein lead to formation of advanced glycation end products (AGEs) and are thought to contribute to the pathogenesis of diabetic complications. AGE inhibitors such as aminoguanidine and pyridoxamine (PM) inhibit both the formation of AGEs and development of complications in animal models of diabetes. PM also inhibits the chemical modification of protein by advanced lipoxidation end products (ALEs) during lipid peroxidation reactions in vitro. We show here that several PM adducts, formed in incubations of PM with linoleate and arachidonate in vitro, are also excreted in the urine of PM-treated animals. The PM adducts N-nonanedioyl-PM (derived from linoleate), N-pentanedioyl-PM, N-pyrrolo-PM, and N-(2-formyl)-pyrrolo-PM (derived from arachidonate), and N-formyl-PM and N-hexanoyl-PM (derived from both fatty acids) were quantified by liquid chromatography-mass spectrometry analysis of rat urine. Levels of these adducts were increased 5-10-fold in the urine of PM-treated diabetic and hyperlipidemic rats, compared with control animals. We conclude that the PM functions, at least in part, by trapping intermediates in AGE/ALE formation and propose a mechanism for PM inhibition of AGE/ALE formation involving cleavage of alpha-dicarbonyl intermediates in glycoxidation and lipoxidation reactions. We also conclude that ALEs derived from polyunsaturated fatty acids are increased in diabetes and hyperlipidemia and may contribute to development of long term renal and vascular pathology in these diseases

Application of the penalty coupling method for the analysis of blood vessels

Due to the significant health and economic impact of blood vessel diseases on modern society, its analysis is becoming of increasing importance for the medical sciences. The complexity of the vascular system, its dynamics and material characteristics all make it an ideal candidate for analysis through fluid structure interaction (FSI) simulations. FSI is a relatively new approach in numerical analysis and enables the multi-physical analysis of problems, yielding a higher accuracy of results than could be possible when using a single physics code to analyse the same category of problems. This paper introduces the concepts behind the Arbitrary Lagrangian Eulerian (ALE) formulation using the penalty coupling method. It moves on to present a validation case and compares it to available simulation results from the literature using a different FSI method. Results were found to correspond well to the comparison case as well as basic theory