Wake Induced Long Range Repulsion of Aqueous Dunes.

Sand dunes rarely occur in isolation, but usually form vast dune fields. The large scale dynamics of these fields is hitherto poorly understood, not least due to the lack of longtime observations. Theoretical models usually abstract dunes in a field as self-propelled autonomous agents, exchanging mass, either remotely or as a consequence of collisions. In contrast to the spirit of these models, here we present experimental evidence that aqueous dunes interact over large distances without the necessity of exchanging mass. Interactions are mediated by turbulent structures forming in the wake of a dune, and lead to dune-dune repulsion, which can prevent collisions. We conjecture that a similar mechanism may be present in wind driven dunes, potentially explaining the observed robust stability of dune fields in different environments

Adipose Tissue-Derived Components:From Cells to Tissue Glue to Treat Dermal Damage

In recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative application of adipose tissue has only recently proven its usefulness; for example, the method is useful in reducing dermal scarring and accelerating skin-wound healing. The therapeutic effect is ascribed to the tissue stromal vascular fraction (tSVF) in adipose tissue. This consists of stromal cells, the trophic factors they secrete and the extracellular matrix (ECM), which have immune-modulating, pro-angiogenic and anti-fibrotic properties. This concise review focused on dermal regeneration using the following adipose-tissue components: adipose-tissue-derived stromal cells (ASCs), their secreted trophic factors (ASCs secretome), and the ECM. The opportunities of using a therapeutically functional scaffold, composed of a decellularized ECM hydrogel loaded with trophic factors of ASCs, to enhance wound healing are explored as well. An ECM-based hydrogel loaded with trophic factors combines all regenerative components of adipose tissue, while averting the possible disadvantages of the therapeutic use of adipose tissue, e.g., the necessity of liposuction procedures with a (small) risk of complications, the impossibility of interpatient use, and the limited storage options.</p

The probabilistic nature of dune collisions in 2D

Dunes are bedforms of different size and shape, appearing throughout aeolian, subaqueous and extraterrestrial environments. Collisions between dunes drive dune field evolution, and are a direct result of interacting dunes of different heights, travelling at different speeds. We perform 2D cellular automaton simulations of collisions between dune pairs migrating in a steady flow. Modelled collisions can result in either ejection, where dunes exchange mass before separating, or downstream- or upstream-dominant coalescence (merging of dunes). For each of these three elementary types of interaction, we identify the mass exchange mechanism and the distinctive intermediate morphologies. Surprisingly, we show that the collision outcome depends probabilistically on the initial dune area ratio r and can be described by a narrow sigmoidal function centred on r=1/2. Finally, we compare our simulations with laboratory experiments of dune collisions, finding good agreement concerning the intermediate morphology and the collision outcome. Our results can motivate further observational or experimental studies that validate our probabilistic collision predictions and fully determine the controls on the coalescence–ejection transition.</p

Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity

Contains fulltext : 159315.pdf (publisher's version ) (Open Access)13 p

Extracellular Matrix-Derived Hydrogels to Augment Dermal Wound Healing:A Systematic Review

Chronic, non-healing, dermal wounds form a worldwide medical problem with limited and inadequate treatment options and high societal burden and costs. With the advent of regenerative therapies exploiting extracellular matrix (ECM) components, its efficacy to augment wound healing is to be explored. This systematic review was performed to assess and compare the current therapeutic efficacy of ECM hydrogels on dermal wound healing. The electronic databases of Embase, Medline Ovid, and Cochrane Central were searched for in vivo and clinical studies on the therapeutic effect of ECM-composed hydrogels on dermal wound healing (April 13, 2021). Two reviewers selected studies independently. Studies were assessed based on ECM content, ECM hydrogel composition, additives, and wound healing outcomes, such as wound size, angiogenesis, and complications. Of the 2102 publications, 9 rodent-based studies were included while clinical studies were not published at the time of the search. Procedures to decellularize tissue or cultured cells and subsequently generate hydrogels were highly variable and in demand of standardization. ECM hydrogels with or without additives reduced wound size and also seem to enhance angiogenesis. Serious complications were not reported. To date, preclinical studies preclude to draw firm conclusions on the efficacy and working mechanism of ECM-derived hydrogels on dermal wound healing. The use of ECM hydrogels can be considered safe. Standardization of decellularization protocols and implementation of quality and cytotoxicity controls will enable obtaining a generic and comparable ECM product. Impact statementExtracellular matrix (ECM)-based hydrogels are biocompatible and harbor growth factors that can instruct tissue healing. Their application is a novelty in (pre)clinical wound healing treatment. This systematic review provides an overview of the current evidence for ECM hydrogels in enhancing wound healing and an extensive overview of the decellularization procedures used. Lastly, challenges and future directions to standardize decellularization procedures and implement quality controls are proposed

Coarsening Dynamics of 2D Subaqueous Dunes

Abstract: Fluid flow over an initially flat granular bed leads to the formation of a surface‐wave instability. The sediment bed profile coarsens and increases in amplitude and wavelength as disturbances develop from ripples into dunes. We perform experiments and numerical simulations to quantify both the temporal evolution of bed properties and the relationship between the initial growth rate and the friction velocity u∗. Experimentally, we study underwater bedforms originating from a thin horizontal particle layer in a narrow and counter‐rotating annular flume. We investigate the role of flow speed, flow depth and initial bed thickness on dune evolution. Bedforms evolve from small, irregular disturbances on the bed surface to rapidly growing connected terraces (2D equivalent of transverse dunes) before splitting into discrete dunes. Throughout much of this process, growth is controlled by dune collisions which are observed to result in either coalescence or ejection (mass exchange). We quantify the coarsening process by tracking the temporal evolution of the bed amplitude and wavelength. Additionally, we perform Large Eddy Simulations (LES) of the fluid flow inside the flume to relate the experimental conditions to u∗. By combining the experimental observations with the LES results, we find that the initial dune growth rate scales approximately as u ∗ 5 ${u}_{\ast }^{5}$ . These results can motivate models of finite‐amplitude dune growth from thin sediment layers that are important in both natural and industrial settings

GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases

The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker (), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s)