12,920 research outputs found
Weight change and quality of life in a community-based population
*Objectives:* This study investigates the longitudinal association between 5-year weight change and quality of life (QoL) in Dutch men and women.

*Design:* A prospective cohort study (1998, 2000, 2003) in a population based sample. Subjects: 2,414 men and women from the Maastricht region of the Netherlands.

*Measurements:* QoL outcomes were measured by the RAND-36 (eight subscales and two overall composite scores, physical and mental health (PCS and MCS)). Weight was measured on a scale. Weight change was calculated as change in weight between 1998 and 2003. In addition, 5-year weight change was also categorized in three groups: weight losers, weight maintainers, and weight gainers. All analyses were stratified for gender.

*Results:* A total of 598 men (50%) and 646 women (54%) maintained their weight, 177 men (15%) and 163 women (14%) lost more than 2.5 kg, and 410 men (35%) and 379 women (32%) gained more than 2.5 kg. Associations between 5-year weight change and QoL were found for MCS ([beta] = 0.13, 95% CI: 0.02|0.24) in women, and PCS ([beta] = -0.09, 95% CI: -0.17|-0.00; [beta] = -0.10, 95% CI: -0.19|-0.01) in men and women respectively. Moreover, associations between weight change and QoL were most pronounced for women of normal weight and obese men. Furthermore, in both genders, weight gainers showed a greater reduction on all physical components of QoL compared with weight maintainers. However, after 5-years weight gainers and weight losers did not significantly differ from weight maintainers in the mean change of MCS and PCS.

*Conclusion:* Weight gain was inversely associated with the physical domains of QoL in women and obese men. Conversely, in women, weight gain was positively associated with the mental domains of QoL. No differences between weight losers and weight gainers were found in mean change of QoL compared with weight maintainers
A Comparative Study of the Valence Electronic Excitations of N_2 by Inelastic X-ray and Electron Scattering
Bound state, valence electronic excitation spectra of N_2 are probed by
nonresonant inelastic x-ray and electron scattering. Within the usual
theoretical treatments, dynamical structure factors derived from the two probes
should be identical. However, we find strong disagreements outside the dipole
scattering limit, even at high probe energies. This suggests an unexpectedly
important contribution from intra-molecular multiple scattering of the probe
electron from core electrons or the nucleus. These effects should grow
progressively stronger as the atomic number of the target species increases.Comment: Submitted to Physical Review Letters April 27, 2010. 12 pages
including 2 figure pages
Cosmic rays studied with a hybrid high school detector array
The LORUN/NAHSA system is a pathfinder for hybrid cosmic ray research
combined with education and outreach in the field of astro-particle physics.
Particle detectors and radio antennae were mainly setup by students and placed
on public buildings. After fully digital data acquisition, coincidence
detections were selected. Three candidate events confirmed a working prototype,
which can be multiplied to extend further particle detector arrays on high
schools.Comment: 10 pages, 6 figures. Nigl, A., Timmermans, C., Schellart, P.,
Kuijpers, J., Falcke, H., Horneffer, A., de Vos, C. M., Koopman, Y., Pepping,
H. J., Schoonderbeek, G., Cosmic rays studied with a hybrid high school
detector array, Europhysics News (EPN), Vol. 38, No. 5, accepted on
22/08/200
Orbit and trajectory measurement with low intensity lead ion beams in the SPS
The orbit measurement system of the CERN SPS was designed to measure the position of dense proton beams with an intensity of up to 0.28 A. The lower design limit for the lead ion beam intensity has been fixed at 35mA. This requires a substantial extension of the dynamic range. We describe the properties of the system and its modifications together with the results obtained for sulphur ion beams in the past and lead ions more recently
Frequency-dependent spontaneous emission rate from CdSe and CdTe nanocrystals: influence of dark states
We studied the rate of spontaneous emission from colloidal CdSe and CdTe
nanocrystals at room temperature. The decay rate, obtained from luminescence
decay curves, increases with the emission frequency in a supra-linear way. This
dependence is explained by the thermal occupation of dark exciton states at
room temperature, giving rise to a strong attenuation of the rate of emission.
The supra-linear dependence is in agreement with the results of tight-binding
calculations.Comment: 11 page
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells. Proteostasis requires an intricate network of protein quality control pathways (the proteostasis network) that work to prevent protein aggregation and maintain proteome health throughout the lifespan of the cell. Collapse of proteostasis has been implicated in the etiology of a number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), the most common adult onset motor neuron disorder. Here, we review the evidence linking dysfunctional proteostasis to the etiology of ALS and discuss how ALS-associated insults affect the proteostasis network. Finally, we discuss the potential therapeutic benefit of proteostasis network modulation in ALS
Intensity and bunch length measurement for lepton beam in the injection lines of the SPS and LEP
We describe a system which is used operationally to measure the absolute intensity of single lepton bunches in a beam transfer line. It is based on the detailed knowledge of every single item of a complex measuring chain that comprises a beam coupler on one end and an acquisition system on the other end. This knowledge can be acquired by a well tested theoretical model and careful measurement of the transfer function of each processing module. A precision better than 3 % can be obtained and no external calibration is required. A value for the bunch length can be deduced from a spectral intensity measurement at two well chosen frequencies
Modelling Kinetics of Plant Canopy Architecture - Concepts and Applications
Most crop models simulate the crop canopy as an homogeneous medium. This approach enables modelling of mass and energy transfer through relatively simple equations, and is useful for understanding crop production. However, schematisation of an homogeneous medium cannot address the heterogeneous nature of canopies and interactions between plants or plant organs, and errors in calculation of light interception may occur. Moreover, conventional crop models do not describe plant organs before they are visible externally e.g young leaves of grasses. The conditions during early growth of individual organs are important determinants of final organ size, causing difficulties in incorporating effects of environmental stresses in such models. Limited accuracy in describing temporal source-sink relationships also contributes to difficulty in modelling dry matter distribution and paramaterisation of harvest indices. Functional-architectural modelling overcomes these limitations by (i) representing crops as populations of individual plants specified in three dimensions and (ii) by modelling whole plant growth and development from the behaviour of individual organs, based on sound models of organs such as leaves and internodes. Since individual plants consist of numerous organs, generic models of organ growth applicable across species are desirable. Consequently, we are studying the development of individual organs, and parameterising it in terms of environmental variables and plant characteristics. Models incorporating plant architecture are currently applied in education, using dynamic visual representation for teaching growth and development. In research, the 3D representation of plants addresses issues presented above and new applications including modelling of pesticide distribution, fungal spore dispersal through splashing and plant to plant heterogeneity
An eccentric companion at the edge of the brown dwarf desert orbiting the 2.4 Msun giant star HIP67537
We report the discovery of a substellar companion around the giant star
HIP67537. Based on precision radial velocity measurements from CHIRON and FEROS
high-resolution spectroscopic data, we derived the following orbital elements
for HIP67537: msin = 11.1 M,
= 4.9 AU and = 0.59. Considering
random inclination angles, this object has 65% probability to be
above the theoretical deuterium-burning limit, thus it is one of the few known
objects in the planet to brown-dwarf transition region. In addition, we
analyzed the Hipparcos astrometric data of this star, from which we derived a
minimum inclination angle for the companion of 2 deg. This value
corresponds to an upper mass limit of 0.3 M, therefore the
probability that HIP67537 is stellar in nature is 7%. The large
mass of the host star and the high orbital eccentricity makes HIP67537 a
very interesting and rare substellar object. This is the second candidate
companion in the brown dwarf desert detected in the sample of intermediate-mass
stars targeted by the EXPRESS radial velocity program, which corresponds to a
detection fraction of = 1.6%. This value is larger than the
fraction observed in solar-type stars, providing new observational evidence of
an enhanced formation efficiency of massive substellar companions in massive
disks. Finally, we speculate about different formation channels for this
object.Comment: Accepted for publication to A&
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