1,100 research outputs found

    On Critical Relative Distance of DNA Codes for Additive Stem Similarity

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    We consider DNA codes based on the nearest-neighbor (stem) similarity model which adequately reflects the "hybridization potential" of two DNA sequences. Our aim is to present a survey of bounds on the rate of DNA codes with respect to a thermodynamically motivated similarity measure called an additive stem similarity. These results yield a method to analyze and compare known samples of the nearest neighbor "thermodynamic weights" associated to stacked pairs that occurred in DNA secondary structures.Comment: 5 or 6 pages (compiler-dependable), 0 figures, submitted to 2010 IEEE International Symposium on Information Theory (ISIT 2010), uses IEEEtran.cl

    Rx plays multiple roles in eye development

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    The homeobox was first identified as a common feature of Drosophila genes that control pattern formation during embryogenesis. These genes have been implicated in the regional specialization of the developing brain, spinal cord and other body structures. Homeobox gene families are highly conserved and encode DNA-binding regulatory proteins. Certain members of the homeobox gene family, including Pax6, Chx10, Lhx2, Otx2, Six3 and Six6, are crucial for development of the eye. A new family of retinal homeobox genes, Rx, is expressed early in embryogenesis in retinal stem cells. This expression pattern, along with results of overexpression and gene deletion studies, is consistent with a role for Rx in retinal stem cell specification and proliferation. In this dissertation, studies of the Rx expression in adult organisms reveal that Rx is abundantly expressed in human and mouse adult neural retina. A number of patients with anophthalmia and microphthalmia were screened and it was found that these conditions are associated with mutations in the Rx gene. The data generated in the first two projects raise a question about a role of Rx at different stages of eye development. To address this problem, a conditional allele of Rx gene was generated. This allele retains normal Rx activity but is a subject to inactivation by Cre recombinase. Using Cre recombinase under a control of forebrain-specific promoter (Foxg1 promoter), Rx conditional inactivation is achieved. Conditional animals (Rx-Foxg1-Cre) lack eyes and optic nerves but otherwise appear to be perfectly normal, making them an ideal model for anophthalmia as seen in the patient population. Analysis of Rx-Foxg1-Cre mice indicate that Rx is critical not only for the initial steps of eye development but also for axial patterning, since both, dorso-ventral and proximo-distal markers are affected

    Problems of implementing e-learning in Russia

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    The article examines the legal grounds for using e-learning in the educational process at the university. An attempt was made to analyze readiness of universities to use elements of e-learning, as well as to identify the main problems of the implementation of e-learning in higher education in Russia.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°ΡŽΡ‚ΡΡ ΠΏΡ€Π°Π²ΠΎΠ²Ρ‹Π΅ основания примСнСния элСктронного обучСния Π² ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ процСссС Π² Π²ΡƒΠ·Π΅. ΠŸΡ€Π΅Π΄ΠΏΡ€ΠΈΠ½ΡΡ‚Π° ΠΏΠΎΠΏΡ‹Ρ‚ΠΊΠ° Π΄Π°Ρ‚ΡŒ Π°Π½Π°Π»ΠΈΠ· готовности Π²ΡƒΠ·ΠΎΠ² ΠΊ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡŽ элСмСнтов элСктронного обучСния, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π²Ρ‹ΡΠ²ΠΈΡ‚ΡŒ основныС ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹ внСдрСния элСктронного обучСния Π² Π²ΡƒΠ·Π°Ρ… России

    To the problem of the material encouragement of the labor of pedagogical workers secondary vocational education

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    Π Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°ΡŽΡ‚ΡΡ вопросы ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ стимулирования Ρ‚Ρ€ΡƒΠ΄Π° пСдагогичСских Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ² ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΉ БПО. ДаСтся Π°Π½Π°Π»ΠΈΠ· Ρ€Π΅Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ состояния ΠΎΠΏΠ»Π°Ρ‚Ρ‹ Ρ‚Ρ€ΡƒΠ΄Π° с ΠΏΡ€ΠΈΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² социологичСского исслСдования ΠΏΠΎ рассматриваСмой ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ΅In the article questions of the material encouragement of the labor of the pedagogical workers of organizations SPO are examined. Is carried out the analysis of the real state of the remuneration for labor with bringing of the results of a sociological study on the problem in questio

    To the determination of the concept of the agreement about the formation

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    In the article is examined the problem of the determination of concept the agreement about the formation on the basis of the analysis of normative lawful reports and the author’s determination of the concept of the agreement about the formation is proposedРассматриваСтся ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ° опрСдСлСния понятия Π΄ΠΎΠ³ΠΎΠ²ΠΎΡ€Π° ΠΎΠ± ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠΈ Π½Π° основС Π°Π½Π°Π»ΠΈΠ·Π° Π½ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½Ρ‹Ρ… ΠΏΡ€Π°Π²ΠΎΠ²Ρ‹Ρ… Π°ΠΊΡ‚ΠΎΠ² ΠΈ прСдлагаСтся авторскоС ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ понятия Π΄ΠΎΠ³ΠΎΠ²ΠΎΡ€Π° ΠΎΠ± ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈ

    Legal aspects of secondary vocational school teachers’ motivation to efficiency improvement

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    The paper discusses the methods of secondary vocational school teachers’ stimulation. We describe both monetary benefits (effective labor contract, pay increase after performance review, and bonuses) and perquisites (diplomas and honorary degrees). The topicality of this research is determined by the absence of highly-qualified teachers; this fact draws attention to the system of secondary vocational teachers’ training. The paper scrutinizes implementation of effective employment contracts in secondary vocational institutions; it also analyzes the role of such contract in pay increase. The problems of implementation of such contracts, as well as the sources of these problems, are discussed. The paper concludes that the real effect of the analyzed contract is poor. Special attention is paid to performance reviews, which are one of the ways to upgrade teacher’s qualification and consequently get higher salary. The drawbacks in the system of performance reviews of teachers are outlined, which may cause effectiveness decreaseΠ’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°ΡŽΡ‚ΡΡ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ стимулирования Ρ‚Ρ€ΡƒΠ΄Π° пСдагогичСских Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ² систСмы срСднСго ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ образования (БПО). РассмотрСны ΠΊΠ°ΠΊ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ стимулы (Π·Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅ эффСктивного ΠΊΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚Π°, ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ Π·Π°Ρ€Π°Π±ΠΎΡ‚Π½ΠΎΠΉ ΠΏΠ»Π°Ρ‚Ρ‹ ΠΏΠΎ ΠΈΡ‚ΠΎΠ³Π°ΠΌ аттСстации, ΠΏΡ€Π΅ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅), Ρ‚Π°ΠΊ ΠΈ Π½Π΅ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ (поощрСния Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ² ΠΏΠΎΡ‡Π΅Ρ‚Π½Ρ‹ΠΌΠΈ Π³Ρ€Π°ΠΌΠΎΡ‚Π°ΠΌΠΈ, присуТдСниС ΠΏΠΎΡ‡Π΅Ρ‚Π½Ρ‹Ρ… Π·Π²Π°Π½ΠΈΠΉ). ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ исслСдования ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π° ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠΎΠΉ нСобСспСчСнности экономики ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΌΠΈ Ρ€Π°Π±ΠΎΡ‡ΠΈΠΌΠΈ ΠΊΠ°Π΄Ρ€Π°ΠΌΠΈ, Ρ‡Ρ‚ΠΎ повысило Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΊ систСмС ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΊΠΈ Ρ€Π°Π±ΠΎΡ‡ΠΈΡ… ΠΊΠ°Π΄Ρ€ΠΎΠ² ΠΈ ΠΊΠ°Π΄Ρ€ΠΎΠ²ΠΎΠΌΡƒ ΠΎΠ±Π΅ΡΠΏΠ΅Ρ‡Π΅Π½ΠΈΡŽ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΉ БПО. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠΈ внСдрСния эффСктивных ΠΊΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚ΠΎΠ² с ΠΏΠ΅Π΄Π°Π³ΠΎΠ³Π°ΠΌΠΈ БПО, исслСдуСтся влияниС Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚Π° Π½Π° Ρ€Π°Π·ΠΌΠ΅Ρ€ Π·Π°Ρ€Π°Π±ΠΎΡ‚Π½ΠΎΠΉ ΠΏΠ»Π°Ρ‚Ρ‹. ΠŸΠΎΠ΄Π½ΠΈΠΌΠ°Π΅Ρ‚ΡΡ вопрос ΠΎ ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ°Ρ… внСдрСния эффСктивного ΠΊΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚Π°, ΠΎΠ±ΠΎΠ·Π½Π°Ρ‡Π΅Π½Ρ‹ ΠΏΡ€ΠΈΡ‡ΠΈΠ½Ρ‹ этих ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ. ΠžΠ±ΠΎΡΠ½ΠΎΠ²Ρ‹Π²Π°Π΅Ρ‚ΡΡ Π²Ρ‹Π²ΠΎΠ΄ ΠΎ Π½Π΅ достиТСнии Ρ€Π΅Π°Π»ΡŒΠ½ΠΎΠΉ эффСктивности рассматриваСмых ΠΊΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚ΠΎ

    Legal foundation of the requirements to secondary vocational institution teachers

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    The need of the Russian economy for highly-qualified staff raises the question of prospective employees training at secondary vocational institutions that are respon-sible for it. The paper analyzes laws and regulations that determine qualification characteristics and requirements to secondary vocational institution teachers; it reveals the problems and offers their solution. A sociological survey was held to prove the conclusions made by the authorsΠŸΠΎΡ‚Ρ€Π΅Π±Π½ΠΎΡΡ‚ΠΈ российской экономики Π² высококвалифицированных Ρ€Π°Π±ΠΎΡ‡ΠΈΡ… ΠΊΠ°Π΄Ρ€Π°Ρ… Π°ΠΊΡ‚ΡƒΠ°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π»ΠΈ вопрос ΠΊΠ°Π΄Ρ€ΠΎΠ²ΠΎΠ³ΠΎ обСспСчСния ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΉ срСднСго ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ образования, ΠΎΡΡƒΡ‰Π΅ΡΡ‚Π²Π»ΡΡŽΡ‰ΠΈΡ… ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΊΡƒ Ρ€Π°Π±ΠΎΡ‡ΠΈΡ… ΠΊΠ°Π΄Ρ€ΠΎΠ². Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π΄Π΅ΠΉΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… Π½ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½Ρ‹Ρ… ΠΏΡ€Π°Π²ΠΎΠ²Ρ‹Ρ… Π°ΠΊΡ‚ΠΎΠ² Π² части установлСния ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… характСристик ΠΈ Ρ‚Ρ€Π΅Π±ΠΎΠ²Π°Π½ΠΈΠΉ ΠΊ пСдагогичСским Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠ°ΠΌ БПО, выявлСны ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹, ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ‹ ΠΏΡƒΡ‚ΠΈ ΠΈΡ… Ρ€Π΅ΡˆΠ΅Π½ΠΈΡ, для Π°Ρ€Π³ΡƒΠΌΠ΅Π½Ρ‚Π°Ρ†ΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ социологичСского исслСдовани

    Occupational mobility: conditions for success

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    The article discusses some requisites of success of occupational mobility: level of education in formal and substantive aspects, personal and business skills, self-development. Particular attention is paid to the educational component. The main reasons for the decline of its quality are identifiedРассмотрСны Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΎΠ±ΡΠ·Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ условия ΡƒΡΠΏΠ΅ΡˆΠ½ΠΎΡΡ‚ΠΈ ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½ΠΎΡΡ‚ΠΈ: ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ образования Π² Ρ„ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½ΠΎΠΌ ΠΈ ΡΠΎΠ΄Π΅Ρ€ΠΆΠ°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ аспСктах, Π»ΠΈΡ‡Π½Ρ‹Π΅ ΠΈ Π΄Π΅Π»ΠΎΠ²Ρ‹Π΅ качСства, саморазвитиС. ОсобоС Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡƒΠ΄Π΅Π»Π΅Π½ΠΎ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ ΡΠΎΡΡ‚Π°Π²Π»ΡΡŽΡ‰Π΅ΠΉ. Π’Ρ‹Π΄Π΅Π»Π΅Π½Ρ‹ основныС ΠΏΡ€ΠΈΡ‡ΠΈΠ½Ρ‹ сниТСния качСства ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈ

    Lawful aspects of prekarization of the labor of the scientific-pedagogical workers

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    In the article the state of the working attitudes of scientific-pedagogical workers is analyzed. Are established the signs of prekarization of workers in these relations. Are examined some lawful aspects of the reasons of prekarization of the labor of the category of workers in question.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ анализируСтся состояниС Ρ‚Ρ€ΡƒΠ΄ΠΎΠ²Ρ‹Ρ… ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΉ Π½Π°ΡƒΡ‡Π½ΠΎ-пСдагогичСских Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ². УстановлСны ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΈ ΠΏΡ€Π΅ΠΊΠ°Ρ€ΠΈΠ·Π°Ρ†ΠΈΠΈ Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ² Π² этих ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡΡ…. РассмотрСны Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΏΡ€Π°Π²ΠΎΠ²Ρ‹Π΅ аспСкты ΠΏΡ€ΠΈΡ‡ΠΈΠ½ ΠΏΡ€Π΅ΠΊΠ°Ρ€ΠΈΠ·Π°Ρ†ΠΈΠΈ Ρ‚Ρ€ΡƒΠ΄Π° рассматриваСмой ΠΊΠ°Ρ‚Π΅Π³ΠΎΡ€ΠΈΠΈ Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ²
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