3D Finite Element Modeling of the 2009 L'Aquila Earthquake Deformation Field

The L'Aquila earthquake (Mw 6.3) occurred on April 6th at 01:32 UTC in the Central Appennines at a depth of about 9 km and was felt all over Central Italy. The main shock was preceded by a long seismic sequence started several months before and was followed by thousands of aftershocks, some of them with Mw>4. We built up a high resolution three-dimensional model, incorporating surface topography, which was discretized using 20-nodes brick elements. The element horizontal size is biased from 500 m to 2 km using the paving meshing algorithm in combination with an appropriate adaptive sizing function. A realistic rheology was introduced from a vp/vpvs travel time tomographic model. We computed the co-seismic deformation induced by the earthquake by means of a recently developed finite elements simulation tool, FEMSA (Finite Element Modeling for Seismic Applications). We used different seismic source models obtained from fault inversion of GPS measurements, joint inversion of strong motion and GPS data and from inversion of DInSAR displacements. The synthetic deformation patterns were compared with the experimental results in order to evaluate which source model better reconciles the data and quantify the trade off introduced by 1D simulations

Importance of earthquake rupture geometry on tsunami modelling: the Calabrian Arc subduction interface (Italy) case study

SUMMARY The behaviour of tsunami waves at any location depends on the local morphology of the coasts, the encountered bathymetric features, and the characteristics of the source. However, the importance of accurately modelling the geometric properties of the causative fault for simulations of seismically induced tsunamis is rarely addressed. In this work, we analyse the effects of using two different geometric models of the subduction interface of the Calabrian Arc (southern Italy, Ionian Sea) onto the simulated tsunamis: a detailed 3-D subduction interface obtained from the interpretation of a dense network of seismic reflection profiles, and a planar interface that roughly approximates the 3-D one. These models can be thought of as representing two end-members of the level of knowledge of fault geometry. We define three hypothetical earthquake ruptures of different magnitudes (Mw 7.5, 8.0, 8.5) on each geometry. The resulting tsunami impact is evaluated at the 50-m isobath in front of coastlines of the central and eastern Mediterranean. Our results show that the source geometry imprint is evident on the tsunami waveforms, as recorded at various distances and positions relative to the source. The absolute differences in maximum and minimum wave amplitudes locally exceed one metre, and the relative differences remain systematically above 20 per cent with peaks over 40 per cent. We also observe that tsunami energy directivity and focusing due to bathymetric waveguides take different paths depending on which fault is used. Although the differences increase with increasing earthquake magnitude, there is no simple rule to anticipate the different effects produced by these end-member models of the earthquake source. Our findings suggest that oversimplified source models may hinder our fundamental understanding of the tsunami impact and great care should be adopted when making simplistic assumptions regarding the appropriateness of the planar fault approximation in tsunami studies. We also remark that the geological and geophysical 3-D fault characterization remains a crucial and unavoidable step in tsunami hazard analyses

Distinct Expression of Inflammatory Features in T Helper 17 Cells from Multiple Sclerosis Patients

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). T helper (Th) 17 lymphocytes play a role in the pathogenesis of MS. Indeed, Th17 cells are abundant in the cerebrospinal fluid and peripheral blood of MS patients and promote pathogenesis in the mouse model of MS. To gain insight into the function of Th17 cells in MS, we tested whether Th17 cells polarized from naïve CD4 T cells of healthy donors and MS patients display different features. To this end, we analysed several parameters that typify the Th17 profile during the differentiation process of naïve CD4 T cells obtained from relapsing-remitting (RR)-MS patients (n = 31) and healthy donors (HD) (n = 28). Analysis of an array of cytokines produced by Th17 cells revealed that expression of interleukin (IL)-21, tumour necrosis factor (TNF)-β, IL-2 and IL-1R1 is significantly increased in Th17 cells derived from MS patients compared to healthy donor-derived cells. Interestingly, IL-1R1 expression is also increased in Th17 cells circulating in the blood of MS patients compared to healthy donors. Since IL-2, IL-21, TNF-β, and IL-1R1 play a crucial role in the activation of immune cells, our data indicate that high expression of these molecules in Th17 cells from MS patients could be related to their high inflammatory status

Effects of bariatric and metabolic surgical procedures on dyslipidemia: a retrospective, observational analysis.

Aim: Obesity and co-existing metabolic comorbidities are associated with increased cardiovascular (CV) morbidity and mortality risks, generally clustered to risk factors such as dyslipidemia. The aim of this study was to evaluate the lipid profile changes in subjects with severe obesity undergoing different procedures of bariatric and metabolic surgery (BMS), sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) in a real-world, clinical setting. Methods: A single-center, retrospective, observational clinical study was performed enrolling patients undergoing BMS. The primary outcome was the change in total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol, and triglycerides. Results: In total, 123 patients were enrolled (males 25.2% and females 74.8%) with a mean age of 48.2 ± 7.9 years and a mean BMI of 47.0 ± 9.1 kg/m2. All patients were evaluated until 16.9 ± 8.1 months after surgery. Total and HDL cholesterol did not change after surgery, while a significant reduction in triglyceride levels was recorded. Moreover, a rapid decline of both LDL and non-HDL cholesterol among follow-up visits was observed. In particular, significant inverse correlations were found between total cholesterol, LDL cholesterol, non-HDL cholesterol, and triglycerides and the number of months elapsed after bariatric surgery. Similarly, a direct correlation was found considering HDL cholesterol. Moreover, total cholesterol, LDL cholesterol, non-HDL cholesterol, and triglycerides significantly changed among visits after RYGB, while no changes were observed in the SG group. Finally, considering lipid-lowering therapies, the improvement in lipid asset was detected only in non-treated patients. Conclusion: This study corroborates the knowledge of the improvement in lipid profile with BMS in clinical practice. Together with sustained weight loss, the BMS approach efficiently corrects dyslipidemia, contributing to decreasing the CV risk

Enabling dynamic and intelligent workflows for HPC, data analytics, and AI convergence

The evolution of High-Performance Computing (HPC) platforms enables the design and execution of progressively larger and more complex workflow applications in these systems. The complexity comes not only from the number of elements that compose the workflows but also from the type of computations they perform. While traditional HPC workflows target simulations and modelling of physical phenomena, current needs require in addition data analytics (DA) and artificial intelligence (AI) tasks. However, the development of these workflows is hampered by the lack of proper programming models and environments that support the integration of HPC, DA, and AI, as well as the lack of tools to easily deploy and execute the workflows in HPC systems. To progress in this direction, this paper presents use cases where complex workflows are required and investigates the main issues to be addressed for the HPC/DA/AI convergence. Based on this study, the paper identifies the challenges of a new workflow platform to manage complex workflows. Finally, it proposes a development approach for such a workflow platform addressing these challenges in two directions: first, by defining a software stack that provides the functionalities to manage these complex workflows; and second, by proposing the HPC Workflow as a Service (HPCWaaS) paradigm, which leverages the software stack to facilitate the reusability of complex workflows in federated HPC infrastructures. Proposals presented in this work are subject to study and development as part of the EuroHPC eFlows4HPC project.This work has received funding from the European High-Performance Computing Joint Undertaking (JU) under grant agreement No 955558. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and Spain, Germany, France, Italy, Poland, Switzerland and Norway. In Spain, it has received complementary funding from MCIN/AEI/10.13039/501100011033, Spain and the European Union NextGenerationEU/PRTR (contracts PCI2021-121957, PCI2021-121931, PCI2021-121944, and PCI2021-121927). In Germany, it has received complementary funding from the German Federal Ministry of Education and Research (contracts 16HPC016K, 6GPC016K, 16HPC017 and 16HPC018). In France, it has received financial support from Caisse des dépôts et consignations (CDC) under the action PIA ADEIP (project Calculateurs). In Italy, it has been preliminary approved for complimentary funding by Ministero dello Sviluppo Economico (MiSE) (ref. project prop. 2659). In Norway, it has received complementary funding from the Norwegian Research Council, Norway under project number 323825. In Switzerland, it has been preliminary approved for complimentary funding by the State Secretariat for Education, Research, and Innovation (SERI), Norway. In Poland, it is partially supported by the National Centre for Research and Development under decision DWM/EuroHPCJU/4/2021. The authors also acknowledge financial support by MCIN/AEI /10.13039/501100011033, Spain through the “Severo Ochoa Programme for Centres of Excellence in R&D” under Grant CEX2018-000797-S, the Spanish Government, Spain (contract PID2019-107255 GB) and by Generalitat de Catalunya, Spain (contract 2017-SGR-01414). Anna Queralt is a Serra Húnter Fellow.With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2018-000797-S)

A first appraisal of the seismogenic and tsunamigenic potential of the largest fault systems in the westernmost Mediterranean

15 pages, 10 figures, 3 tables, supplementary material https://doi.org/10.1016/j.margeo.2022.106749.-- Data availability: The data (3D complex mesh of the ARFS and rake values, and the resulting grid files of the tsunami simulations containing the maximum wave amplitude) are archived at PANGAEA repository (https://doi.pangaea.de/10.1594/PANGAEA.941092).-- The EMODnet bathymetry is available at https://www.emodnet-bathymetry.eu/. The stochastic slip distributions have been produced by the code ANTI-FASc (https://github.com/antonioscalaunina/ANTI-FASc) a platform partially based on the code k223d (Herrero and Murphy, 2018 available at https://github.com/s-murfy/k223d), in turn based on the slipk2 (available at https://github.com/andherit/slipk2) and the trilateration codes (available at https://github.com/andherit/trilateration)The westernmost Mediterranean hosts part of the plate boundary between the European and African tectonic plates. Based on the scattered instrumental seismicity, this boundary has been traditionally interpreted as a wide zone of diffuse deformation. However, recent seismic images and seafloor mapping studies support that most of the plate convergence may be accommodated in a few tectonic structures, rather than in a broad region. Historical earthquakes with magnitudes Mw > 6 and historical tsunamis support that the low-to-moderate instrumental seismicity might also have led to underestimation of the seismogenic and tsunamigenic potential of the area. We evaluate the largest active faults of the westernmost Mediterranean: the reverse Alboran Ridge, and the strike-slip Carboneras, Yusuf and Al-Idrissi fault systems. For the first time, we use a dense grid of modern seismic data to characterize the entire dimensions of the main fault systems, accurately describe the geometry of these structures and estimate their seismic source parameters. Tsunami scenarios have been tested based on 3D-surfaces and seismic source parameters, using both uniform and heterogeneous slip distributions. The comparison of our results with previous studies, based on limited information on the fault geometry and kinematics, indicates that accurate fault geometries and heterogeneous slip distributions are needed to properly assess the seismic and tsunamigenic potential in this area. Based on fault scaling relations, the four fault systems have a large seismogenic potential, being able to generate earthquakes with Mw > 7. The reverse Alboran Ridge Fault System has the largest tsunamigenic potential, being able to generate a tsunami wave amplitude greater than 3 m in front of the coasts of Southern Spain and Northern AfricaThis work is supported by the Cluster of Excellence “The Future Ocean”, within the framework of the Excellence Initiative by the Deutsche Forschungsgemeinschaft (DFG) on behalf of the German federal and state governments. This study benefited from an EU Marie Skłodowska-Curie Individual Fellowship to LGP (H2020-MSCA-IF-2017 796013). LGP, CS, FM and RB acknowledge the resources made available by the SISMOLAB-3D at INGV. This work has been carried out in collaboration with the Grup de Recerca Consolidat de la Generalitat de Catalunya “Barcelona Center for Subsurface Imaging” (2017 SGR 1662), and acknowledges the ICM “Severo Ochoa Centre of Excellence” accreditation (CEX2019-000928-S)Peer reviewe

Gait patterns in Prader-Willi and Down syndrome patients

<p>Abstract</p> <p>Background</p> <p>Prader-Willi (PWS) and Down Syndrome (DS) are two genetic disorders characterised by some common clinical and functional features. A quantitative description and comparison of their patterns would contribute to a deeper understanding of the determinants of motor disability in these two syndromes. The aim of this study was to measure gait pattern in PWS and DS in order to provide data for developing evidence-based deficit-specific or common rehabilitation strategies.</p> <p>Methods</p> <p>19 PWS patients (17.7-40 yr) and 21 DS patients (18-39 yr) were evaluated with an optoelectronic system and force platforms for measuring kinematic and kinetic parameters during walking. The results were compared with those obtained in a group of normal-weight controls (Control Group: CG; 33.4 + 9.6 yr).</p> <p>Results and Discussion</p> <p>The results show that PWS and DS are characterised by different gait strategies. Spatio-temporal parameters indicated a cautious, abnormal gait in both groups, but DS walked with a less stable strategy than PWS. As for kinematics, DS showed a significantly reduced hip and knee flexion, especially at initial contact and ankle range of motion than PWS. DS were characterised by lower ranges of motion (p < 0.05) in all joints than CG and PWS. As for ankle kinetics, both PWS and DS showed a significantly lower push-off during terminal stance than CG, with DS yielding the lowest values. Stiffness at hip and ankle level was increased in DS. PWS showed hip stiffness values close to normal. At ankle level, stiffness was significantly decreased in both groups.</p> <p>Conclusions</p> <p>Our data show that DS walk with a less physiological gait pattern than PWS. Based on our results, PWS and DS patients need targeted rehabilitation and exercise prescription. Common to both groups is the aim to improve hypotonia, muscle strength and motor control during gait. In DS, improving pelvis and hip range of motion should represent a major specific goal to optimize gait pattern.</p

Spontaneous twin anemia polycythemia sequence: diagnosis, management, and outcome in an international cohort of 249 cases.

BACKGROUND: Twin anemia polycythemia sequence is a chronic form of unbalanced fetofetal transfusion through minuscule placental anastomoses in monochorionic twins, leading to anemia in the donor and polycythemia in the recipient. Owing to the low incidence of twin anemia polycythemia sequence, data on diagnosis, management, and outcome are limited. OBJECTIVE: This study aimed to investigate the diagnosis, management, and outcome in a large international cohort of spontaneous twin anemia polycythemia sequence. STUDY DESIGN: Data from the international twin anemia polycythemia sequence registry, retrospectively collected between 2014 and 2019, were used for this study. A total of 17 fetal therapy centers contributed to the data collection. The primary outcomes were perinatal mortality and severe neonatal morbidity. Secondary outcomes included a risk factor analysis for perinatal mortality and severe neonatal morbidity. RESULTS: A total of 249 cases of spontaneous twin anemia polycythemia sequence were included in this study, 219 (88%) of which were diagnosed antenatally and 30 (12%) postnatally. Twin anemia polycythemia sequence was diagnosed antenatally at a median gestational age of 23.7 weeks (interquartile range, 9.7-28.8; range, 15.1-35.3). Antenatal management included laser surgery in 39% (86 of 219), expectant management in 23% (51 of 219), delivery in 16% (34 of 219), intrauterine transfusion (with partial exchange transfusion) in 12% (26 of 219), selective feticide in 8% (18 of 219), and termination of pregnancy in 1% (3 of 219) of cases. Perinatal mortality rate was 15% (72 of 493) for the total group, 22% (54 of 243) for donors, and 7% (18 of 242) for recipients (P<.001). Severe neonatal morbidity occurred in 33% (141 of 432) of twins with twin anemia polycythemia sequence and was similar for donors (32%; 63 of 196) and recipients (33%; 75 of 228) (P=.628). Independent risk factors for spontaneous perinatal mortality were donor status (odds ratio, 3.8; 95% confidence interval, 1.9-7.5; P<.001), antenatal twin anemia polycythemia sequence stage (odds ratio, 6.3; 95% confidence interval, 1.4-27.8; P=.016 [stage 2]; odds ratio, 9.6; 95% confidence interval, 2.1-45.5; P=.005 [stage 3]; odds ratio, 20.9; 95% confidence interval, 3.0-146.4; P=.002 [stage 4]), and gestational age at birth (odds ratio, 0.8; 95% confidence interval, 0.7-0.9; P=.001). Independent risk factors for severe neonatal morbidity were antenatal twin anemia polycythemia sequence stage 4 (odds ratio, 7.9; 95% confidence interval, 1.4-43.3; P=.018) and gestational age at birth (odds ratio, 1.7; 95% confidence interval, 1.5-2.1, P<.001). CONCLUSION: Spontaneous twin anemia polycythemia sequence can develop at any time in pregnancy from the beginning of the second trimester to the end of the third trimester. Management for twin anemia polycythemia sequence varies considerably, with laser surgery being the most frequent intervention. Perinatal mortality and severe neonatal morbidity were high, the former especially so in the donor twins

Il Centro Allerta Tsunami (CAT) dell’INGV

The Tsunami Alert Centre of the INGV (CAT-INGV) was created with the aim of contributing to the mitigation of the risk due to tsunamis triggered by earthquakes on the Italian and Mediterranean coasts. Tsunamis of seismic origin, in addition to being the most frequent, are those that can be detected more quickly. Seismic waves, in fact, travel in the crust with a much higher speed than that of tsunami waves. With effective seismic networks connected in real time, an "Early Warning" system can be implemented, i.e. a system capable of sending an alert signal before the arrival of the tsunami waves, at least from a certain distance from the source. The CAT-INGV has two main tasks. The first one is to provide alerts to the competent authorities in the event of potential tsunamigenic earthquakes in the Mediterranean, taking into account the criteria defined by the Department of Civil Protection for this purpose. The second one consists in carrying out the necessary studies for the definition of the probabilistic danger of tsunamis for the Italian coasts, starting from those of seismic origin (Seismic Probabili-stic Tsunami Hazard Analysis, SPTHA). In this contribution the first aspect is described, while the realization of the studies on hazard at the Mediterranean scale is the subject of research described in various recent articles (Lorito et al., 2015; Grezio et al., 2017; Selva et al., 2017a; Selva et al., 2017b). The TSUMAPS-NEAM project, funded by the European Commission and concluded at the end of 2017, provided the first hazard map for the Mediterranean region and the north-east Atlantic (Basili et al., 2017).Published91-975T. Modelli di pericolosità sismica e da maremotoN/A or not JC

NEAMTHM18

European-Union Civil Protection Mechanism, DG-ECHO, Agreement Number: ECHO/SUB/2015/718568/PREV26Published6T. Studi di pericolosità sismica e da maremoto1SR TERREMOTI - Sorveglianza Sismica e Allerta Tsunami2SR TERREMOTI - Gestione delle emergenze sismiche e da maremoto4IT. Banche dat