Igor Tomeš — odborný konzultant: reflexe principů práce v praxi odborného konzultanta

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Editorial

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Aplikační příležitosti metody Social Return on Investment v sociální práci v ČR

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Analysis of requirements on biobank and study workflows

Human biobanks, which are the core of BBMRI-ERIC medical research infrastructure, are repositories of biological material and data associated with the research participants (donors or patients willing to participate in the research). The associated data covers a broad range of data types: from data collected directly from the research participants and medical processes related to them, to data generated from the biological material. This document focuses on describing biobank data processing workflows that were selected for piloting in EGI-Engage the biobanks by the BBMRI.nl and BBMRI.cz (national nodes of BBMRI-ERIC) together with their associated biobanks. The main focus is on proteomics and genomics workflows, which cover both extremes of privacy-sensitive data processing spectrum: from relatively non-sensitive applications to very sensitive ones

HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy

ABSTRACT: Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructural myelopathy in NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable healthy controls, 18 patients with mild NMDCCC and 15 patients with severe NMDCCC, the protocol provided higher signal-to-noise ratio, enhanced visualization of white/gray matter structures in microstructural maps, improved dMRI metric reproducibility, preserved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group differences when compared to DTI-RESOLVE protocol (SE = 87.88%, SP = 76.92%). Of the 56 tested microstructural parameters, HARDI-ZOOMit yielded significant patient-control differences in 19 parameters, whereas in DTI-RESOLVE data, differences were observed in 10 parameters, with mostly lower robustness. Novel marker the white-gray matter diffusivity gradient demonstrated the highest separation. HARDI-ZOOMit protocol detected larger number of crossing fibers (5–15% of voxels) with physiologically plausible orientations than DTI-RESOLVE protocol (0–8% of voxels). Crossings were detected in areas of dorsal horns and anterior white commissure. HARDI-ZOOMit protocol proved to be a sensitive and practical tool for clinical quantitative spinal cord imaging

A low-cost system for seismocardiography-based cardiac triggering: A practical solution for cardiovascular magnetic resonance imaging at 3 tesla

This study describes a pilot clinical validation of a new low-cost system for the continuous monitoring of the human body's cardiorespiratory activities within the magnetic resonance examination area. This study primarily focuses on monitoring cardiac activity and the related cardiac triggering. The patented system tested by the authors is based on seismocardiography (SCG). The study was conducted on 18 subjects on a Siemens Prisma 3T MR scanner. Standard anatomical and diffusion sequences were used to test cardiac activity monitoring. A wide range of commonly used diagnostic sequences were used to test imaging of the heart by means of cardiac triggering. System functionality was verified against a commercially available electrocardiography (ECG) system. Monitoring of cardiac activity (detection of the R-R interval in ECG and the AO-AO interval in SCG) was objectively evaluated by determining the overall probability of correct detection (ACC), sensitivity (SE), positive predictive value (PPV), and harmonic mean between SE and PPV, i.e. F1. Imaging quality control using Cardiac Triggering was performed by subjective evaluation of images by the physicians. The study conducted clearly confirmed the functionality of the system in terms of continuous cardiac activity monitoring. In all 18 subjects, a mean PPV > 99% was achieved; F1 > 99 %; SE > 99 %; ACC > 98 %; 1.96 sigma < 3.5 bpm. Also, Cardiac Triggering functionality was confirmed by the physicians on the basis of analyzing cardiac images using the T1/T2 balanced echo sequences and the T1 flash sequence measured natively.Web of Science711862911860

Qualitative diagnostics in fitness center

Title: Qualitative diagnostics in fitness center. The aim of the diploma thesis: The aim of the theoretical part of the diploma thesis is to summarize the knowledge about the diagnostic entrance test for motion assumptions in fitness and afterwards to help as a study material for people who are interested in being educated in this department. The aim of the practical part of the diploma thesis is to perform the model situation of the diagnostic entrance test in the fitness center carried out in the presence of 10 certificated personal trainers with many years of experience and then with help of semi-structured dialogs and the overall analysis of the concept of the diagnostic, together with an analysis of their experience with diagnostic entrance test in fitness as a whole. Subsequently these data are compared with the theoretical part of this thesis. Objectives: There was used the method of analyzing specialist literature and qualitative research. The qualitative research was done in the fitness center. Results: The outcome of the project supported the theory that the diagnostic entrance test is still not common part of the work of fitness trainer and commonly implemented diagnostics in fitness does not match the theoretical principles of diagnostics, but it is sufficient for the purposes of..

The Principles of Funding of the Public and Voluntary Formalised Solidarity in the Social Care Services in the Czech Republic

Title: The Principles of Funding of the Public and Voluntary Formalised Solidarity in the Social Care Services in the Czech Republic Abstract: The social care services are a specific system within the social protection system. Opposed to the public benefit systems they allow the coexistence of public and voluntary solidarity. There are many welfare state models and systems of cooperation of the public and NGOs in Europe. These models offer differently formed relationships of their entities. This thesis raises the question of finding a more convenient organisation of the whole system of the social care services in the Czech Republic where the problem is currently being discussed The objective of the thesis is to find possibilities of public and voluntary solidarity in the social care services settings and to suggest ways for their cooperation. The research is mainly based on qualitative methods. Firstly, the causal links of statistical nature from the fields of demography, social relations and economics are introduced. In the next step a combination of methods of in depth interviews and expert discussions is used. They focus on public solidarity and regulation in the system. The last research step brings 3 case studies with examples of the best practice in financing of NGOs in the social care services..