God's words, women's voices : discretio spirituum in the writing of late-medieval women visionaries.

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Queer Touch Between Holy Women: Julian of Norwich, Margery Kempe, Birgitta of Sweden, and the Visitation

Under embargo until: 2021-12-17This essay takes a new approach to the well-known meeting between two late-medieval English visionary women, Margery Kempe and the anchoress Julian of Norwich, as described in The Book of Margery Kempe. In this analysis their conversation subtly evokes a long history of women concentrating their subversive power through intimate, spiritual exchange, a history reaching back to the Biblical Visitation scene and expressed in its medieval artistic and literary instantiations. A queer reading illuminates the way that such female same-sex relationships challenge patriarchal systems by offering a privileged access to God outside clerical supervision. By examining Margery and Julian’s encounter, Luke’s Visitation passage, its depiction in a late-medieval Book of Hours, and comparing two different Middle English translations of a Visitation vision in Birgitta of Sweden’s Revelations, the full transgressive effect of queer touch between women—or even its unspoken possibility—emerges.acceptedVersio

The Putative bZIP Transcripton Factor BzpN Slows Proliferation and Functions in the Regulation of Cell Density by Autocrine Signals in Dictyostelium

The secreted proteins AprA and CfaD function as autocrine signals that inhibit cell proliferation in Dictyostelium discoideum, thereby regulating cell numbers by a negative feedback mechanism. We report here that the putative basic leucine zipper transcription factor BzpN plays a role in the inhibition of proliferation by AprA and CfaD. Cells lacking BzpN proliferate more rapidly than wild-type cells but do not reach a higher stationary density. Recombinant AprA inhibits wild-type cell proliferation but does not inhibit the proliferation of cells lacking BzpN. Recombinant CfaD also inhibits wild-type cell proliferation, but promotes the proliferation of cells lacking BzpN. Overexpression of BzpN results in a reduced cell density at stationary phase, and this phenotype requires AprA, CfaD, and the kinase QkgA. Conditioned media from high-density cells stops the proliferation of wild-type but not bzpN− cells and induces a nuclear localization of a BzpN-GFP fusion protein, though this localization does not require AprA or CfaD. Together, the data suggest that BzpN is necessary for some but not all of the effects of AprA and CfaD, and that BzpN may function downstream of AprA and CfaD in a signal transduction pathway that inhibits proliferation

Decisions at the data border : discretion, discernment and security

Amidst a widespread turn to data analysis and automated screening in security contexts, the question of how decisions are made at the interface of embodied humans and algorithmic processes becomes pressing. This article is concerned with the production of security decisions at the data border. It makes two contributions. It first presents qualitative fieldwork conducted amongst data processors at a European smart border targeting centre and, second, traces a largely obscured cultural history of discretion as means of reflecting on the politics of contemporary data-led decisionmaking. Discretion is an important concept in contemporary administrative contexts, referring to a decision about the (non-)application of a rule in contexts of public power and authority. Its etymon, discretio, however, referred historically to spiritual and visual discernment, as well as prudence and humility. I present the history of discretion to make two arguments: 1) decisionmaking at the data border is an uncertain visual practice oriented to seeing and authorizing what is there and 2) discretion in contemporary data-led contexts revises the conventional ethical relationship between general and particular that has always been intrinsic to discretion. My overall point is that contemporary debates about judgement in automated security decisions are the most recent manifestation of long-standing tensions between rule and judgement, authorization and uncertainty

Средство мобильной эксплуатации медицинских приборов жизнеобеспечения

Работа направлена на разработку средства, которое позволит повысить мобильность пациентов при эксплуатации медицинских приборов жизнеобеспечения. Формулирование требований к проектированию средства на основе принципов универсального дизайна позволит удовлетворять потребности более широкого круга пациентов. Разрабатываемый объект предназначен для улучшения процесса выздоровления.The work is aimed at developing a tool that will increase patient mobility in the operation of medical life-support devices. The formulation of requirements for the design of the tool based on the principles of universal design will allow to meet the needs of a wider range of patients. The object is designed to improve the recovery process