Роль метаболического синдрома на течение и исход нпвп-гастропатии

Metabolic syndrome is a significant global problem. Many of these patients have to take NSAIDs for a long time as a baseline treatment for associated diseases, the side effects of which on the gastric mucosa known to many specialists. The purpose of the study was to determine the role of metabolic syndrome in the course and outcome of NSAID-gastropathy. Selected 84 patients from 44 to 69 years, divided into 3 groups: 1 group - 31 people with NSAID-gastropathy and MS, 2 group - 24 people with NSAID-gastropathy and without MS, 3 group - 33 patients with MS, taking NSAIDs without NSAID gastropathy. Clinical and anamnestic data were determined, anthropometric parameters were assessed, the biochemical blood test was performed to determine the lipid spectrum, fasting capillary blood glucose level and esophagogastroduodenoscopy (EGDS) – before and 4 weeks after therapy with proton pump inhibitors (PPI) for all subjects.Data processing performed using the software package Excel, Annova and Statistica 10.The process of GM erosions healing in subjects with MS and NSAID-gastropathy takes a longer period. The dominant factors in the development of erosive lesions are the levels of HDL cholesterol, degree of hypertension and H. pylori infection. Duration of treatment is mainly influenced by LDL cholesterol levels, TG and TH levels, and the degree of AH. Conclusions. MS makes a negative contribution during NSAID gastropathy.El síndrome metabólico (EM) es un problema importante de salud pública comparable a una pandemia no transmisible. Su combinación frecuente con enfermedad coronaria (CHD) y osteoartritis dictamina la necesidad durante mucho tiempo de recetar medicamentos antiinflamatorios no esteroideos (AINE), que pueden estar acompañados por el desarrollo de daño ulcerativo erosivo en el tracto gastrointestinal. El objetivo del trabajo fue determinar el papel de la EM en el curso y el resultado de la gastropatía por AINE. Material y métodos. En dinámica, se examinaron 84 pacientes con angina de pecho IIFK de 44 a 69 años, que recibieron preparaciones de ácido acetilsalicílico, divididos en 3 grupos: grupo 1 - 31 personas con gastropatía por AINE en combinación con EM; Grupo 2: 24 personas con AINE-gastropatía sin EM; Grupo 3: 33 pacientes con EM en combinación con gastritis crónica, que toman AINE sin el desarrollo de lesiones erosivas y ulcerosas del estómago. Los pacientes fueron examinados en dinámica durante un mes. Los pacientes del primer y segundo grupo con gastropatía por AINE y el tercer grupo con gastritis crónica recibieron inhibidores de la bomba de protones (IBP) en una dosis diaria de 20 mg durante un mes. En ausencia de epitelización de la erosión durante meses, el tratamiento con IBP se prolongó por otras 4 semanas. Resultados Los resultados de un examen endoscópico realizado un mes después mostraron que solo 10 de 31 personas mostraron curación completa de la erosión en el primer grupo, en el segundo grupo, de 24 en 24. Se pudo concluir que la presencia de hipertensión debe atribuirse a la manifestación de gastropatía por AINE, nivel bajo Infección por HDL y H. pylori.Введение. Метаболический синдром (МС) представляет собой существенную проблему дляздравоохранения, сопоставимую с неинфекционной пандемией. Частое его сочетание с ишемической болезнью сердца(ИБС) и остеоартрозом диктует необходимостьв течение длительного времени назначать нестероидные противовоспалительные препараты (НПВП), что может сопровождаться развитием эрозивно-язвенного повреждения желудочно-кишечного тракта.   Целью работы было определение ролиМС в течении и исходе НПВП-гастропатии. Материал и методы. Материалы и методы. В динамике обследовано 84 пациентасо стенокардией напряжения IIФК в возрасте от 44 до 69 лет, получающие препараты ацетилсалициловой кислоты.Больные были разделенные на 3 группы: 1-я группа – 31 человек с НПВП-гастропатиейв сочетании с МС; 2-я группа – 24 человека с НПВП-гастропатиейбез МС; 3 группа – 33 пациента с МС в сочетании с хроническим гастритом, принимающие НПВП без развития эрозивно-язвенных повреждений желудка. Больные обследованы в динамикена протяжении месяца.Пациенты 1-й и 2-й группы с НПВП-гастропатией и 3-й группы с хроническим гастритом получали ингибиторы протонной помпы (ИПП) в суточной дозе 20 мг в течение месяца.При отсутствии эпителизации эрозий в течение месяца лечение ИПП пролонгировали еще на 4 недели. Результаты. Результаты эндоскопического исследования, проведенные через месяц показали, что в 1-йгруппе только у 10 из 31 человекаотмечалось полное заживление эрозий;во 2-й- у 19 - из 24. Выводы.К способствующим манифестации НПВП-гастропатии следует относить наличие АГ, низкий уровень ЛПВП, и инфицированность H.pylori. &nbsp

A new, purely photometric method for determination of resonance locations in spiral galaxies

The knowledge of the positions of the corotation resonance in spiral arms is a key way to estimate their pattern speed, which is a fundamental parameter determining the galaxy dynamics. Various methods for its estimation have been developed, but they all demonstrate certain limitations and a lack of agreement with each other. Here, we present a new method for estimating the corotation radius. This method takes into account the shape of the profile across the arm and its width and, thus, only photometric data is needed. The significance of the method is that it can potentially be used for the farthest galaxies with measurable spiral arms. We apply it to a sample of local galaxies from Savchenko et al. and compare the obtained corotation radii with those previously measured in the literature by other methods. Our results are in good agreement with the literature. We also apply the new method to distant galaxies from the COSMOS field. For the first time, corotation locations for galaxies with photometric redshifts up to $z\sim0.9$ are measured.Comment: accepted in MNRAS Letter

Activity of N.A. Semashko during the evacuation of the 1st Moscow Order of Lenin Medical Institute to Ufa (1941–1942)

An attempt is made to systematize the main directions of N.A. Semashkos activity during the evacuation of the 1st Moscow Order of Lenin Medical Institute (MOLMI) during the Great Patriotic War to Ufa (October 1941 March 1942) is undertaken. The significance of its results for the Bashkir State Medical Institute (now Bashkir State Medical University) is evaluated. It is shown that the joint work of N.A. Semashko with the teaching staff of the 1st MOLMI and Bashkir medical institute improved the pedagogical and scientific qualification of teachers at Bashkir medical institute, improved the existing forms of teaching, scientific and educational work during the period of war and created new ones. Professor N.A. Semashko actively worked in several directions during complicated conditions of evacuation. Besides pedagogical and scientific activities, he was occupied with the training of scientific-pedagogical personnel, took part in advanced training of physicians and medical workers, organized educational work with the population, delivered brilliant lectures to the crowded halls. In addition, as the first Peoples Commissar of Health of the RSFSR, he helped the Peoples Commissariat of Health of the Bashkir ASSR in organizing the work of evacuation hospitals and rendering assistance to health care institutions located on the territory of the Bashkir ASSR

A new catalogue of polar-ring galaxies selected from the SDSS

(Abridged) Galaxies with polar rings (PRGs) are a unique class of extragalactic objects allowing to investigate a wide range of problems, linked with the formation and evolution of galaxies, and to study the properties of their dark haloes. The progress in the study of PRGs is constrained by a small number of known objects of this type. Up to date, we can only attribute about two dozens of kinematically-confirmed galaxies to this class, mostly from Whitmore et al. (1990) catalogue. We present a new catalogue of PRGs based on the results of the original Galaxy Zoo project. Based on the preliminary classification of the Galaxy Zoo, we viewed more than 40000 images of the Sloan Digital Sky Survey (SDSS) and selected 275 galaxies, included in our catalogue. Our Sloan-based Polar Ring Catalog (SPRC) contains 70 galaxies that we classified as "the best candidates", among which we expect to have a very high proportion of true PRGs, and 115 good PRG candidates. 53 galaxies are classified as PRG related objects.We identified 37 galaxies that have their presumed polar rings seen almost face-on. The SPRC objects are on the average fainter and located further away than the galaxies from the catalog by Whitmore et al., although our catalogue does include dozens of new nearby candidate PRGs. The new catalogue significantly increases the number of genuine PRG candidates, and may serve as a good basis both for the further detailed study of individual galaxies, and for the statistical analysis of PRGs as a separate class of objects. We performed spectroscopic observations of six galaxies from the SPRC at the 6-m telescope. The existence of polar rings was confirmed in five galaxies, and one object appeared to be a projection of a pair of galaxies. Adding the literature data, we can already classify 10 galaxies from our catalogue to the kinematically-confirmed PRGs.Comment: 29 pages, 7 figures, accepted for publication in MNRAS. Comments welcom

Comorbid status of patients with hypertension

Aim. To establish age and gender characteristics, nosological structure of comorbidity among persons 2099 years with hypertension. Materials and methods. The study is based on data from 21 514 electronic health records of the population (2099 years old) with hypertension, mean age 63.0 years, 68.2% women. Diseases associated with hypertension with a frequency above 10% were analyzed. Results. In the sample of people with hypertension, concomitant diseases were detected in 82.7% of cases, 1 disease accompanies 21.0% of the sample with hypertension, 2 diseases 17.9%, 3 diseases 14.0%, 4+ diseases 29.8%. The frequency of association of hypertension with 1 concomitant disease at the 2029 years is 60.8% of cases, at 3039 years 65.1%, at 4049 years 73.9%, at 5059 years 81.1%, 6069 years 85.8%, 7079 years 87.3%, 80+ years 86.2% of cases. Among women with hypertension, the average number of concomitant diseases is higher compared to men (3.47 vs 2.4 cases; p0.001). Among young and middle-aged people, hypertension in most cases is associated with osteochondrosis, osteoarthritis, chronic pancreatitis, gastritis and duodenitis, retinal diseases, thyroid diseases, the female with hypertension accompanied by benign breast disease and menopausal disorders. Hypertension in the elderly is most often associated with cerebrovascular disease, coronary heart disease, diabetes mellitus, senile cataract, but osteochondrosis and osteoarthritis also do not lose their relevance. Conclusion. The existing system of organization of medical care cannot meet the needs of patients with comorbidity, which indicates the need to reorient medical care towards patient-centered care

АНАЛИЗ ГИНЗЕНОЗИДОВ В КОРНЯХ ЖЕНЬШЕНЯ НАСТОЯЩЕГО (PANAX GINSENG), ИНТРОДУЦИРОВАННОГО В ЦЕНТРАЛЬНОМ БОТАНИЧЕСКОМ САДУ НАН БЕЛАРУСИ

For the first time, a detailed study of the qualitative and quantitative composition of ginsenosides in the Panax ginseng roots was carried out with the help of high-performance liquid chromatography combined with mass spectrometry (HPLC-MS). The plants were introduced into the conditions of the Republic of Belarus at the experimental plot of the Central Botanical Garden of the National Academy of Sciences of Belarus. It was found that in the examined roots, all basic neutral glycosides of ginseng (ginsenosides Rb1, Rc, Rb2/Rb3, Rd, Rf, Rg1 and Re), as well as their malonylated derivatives (malonylginsenosides Rb1, Rc, Rb2/Rb3, Rd, Rg1 and Re) and some “minor” ginsenosides (20-gluco-ginsenoside Rf, notoginsenosides R1 and R2, isomers of malonyl-ginsenosides Rb1 and Rd) are present. The research also showed that different parts of the P. ginseng roots differ significantly in a total content of ginsenosides: for the main root, this parameter was 3.3 % of dry mass, and for the lateral roots – 7.8 % of dry mass.Впервые с помощью высокоэффективной жидкостной хроматографии, совмещенной с массспектрометрией (ВЭЖХ-МС) проведено подробное изучение качественного и количественного состава гинзенозидов в корнях женьшеня настоящего (P. ginseng C. A. Mey.), интродуцированного в условиях Республики Беларусь (опытный участок ЦБС НАН Беларуси). Установлено, что в изученных корнях присутствуют все основные нейтральные гликозиды женьшеня (гинзенозиды Rb1, Rc, Rb2/Rb3, Rd, Rf, Rg1 и Re), а также их малонилированные производные (малонил-гинзенозиды Rb1, Rc, Rb2/Rb3, Rd, Rg1 и Re) и некоторые «минорные» гинзенозиды (20-глюко-гинзенозид Rf, нотогинзенозиды R1 и R2, изомеры малонил-гинзенозидов Rb1 и Rd). Показано также, что разные части корней P. ginseng существенно отличаются по суммарному содержанию гинзенозидов: для основного корня этот параметр составил 3,3 % от сухой массы, а для боковых корней – 7,8 % от сухой массы

Promises and Hurdles of Medical Tourism Development in the Russian Federation

© Copyright © 2020 Daykhes, Jakovljevic, Reshetnikov and Kozlov. Background: Development of medical tourism improves access to healthcare in countries where the necessary medical procedures are not available or accessible to its citizens. In the country of destination, medical tourism stimulates economic development and raises the quality of healthcare provided. There are both microeconomic and macroeconomic factors affecting the development of medical tourism. Microeconomic factors relate to the receivers and providers of healthcare. Macroeconomic factors relate to the government policy being implemented to support the development of medical tourism. This study aims to identify factors affecting the development of medical tourism in Russia. Methodology: An expert survey of 36 heads of medical organizations in Russia was conducted to assess the problems that impede the development of the medical care system to foreign patients in Russia, as well as propose possible solutions. The degree of covariation among experts was calculated using the Kendall concordance coefficient. Results: The experts gave consistent evaluation to numerous sets of problems that impede the development and proposed concrete measures for the development of inbound medical tourism in Russia. These measures ranged from microeconomic to macroeconomic approaches and were directed toward a holistic and coordinated development of medical tourism within Russia. Conclusion: Based on the results, Russia has several micro- and macroeconomic competitive advantages and disadvantages in facilitating medical tourism. The study yielded a set of measures for the development of inbound medical tourism and the promotion of the export of medical services in the Russian Federation, which can be extended to other countries or parties who are seeking to develop medical tourism

CAREER MANAGEMENT IN MEDICAL ORGANIZATIONS

The aim of this work was to determine the specific characteristics of the career of a physician in medical organizations, as well as to develop organizational and methodological tools for monitoring its success and improving its management.Materials and methods. A retrospective anonymous survey and expert interviews were carried out among administrative medical staff. The state of career management in the field was analyzed, along with the availability of relevant documents in medical organizations.Results. The distinctive characteristics of the career of a physician (goals, principles, predictors of career advancement, types, basic models) have been established. The effectiveness of professional training, differentiated by functions, for managers in medical organizations has been shown. The possibility of changing the duration of modules included into the curriculum of study is substantiated. Evaluation tools have been developed to monitor and facilitate the carrer management of physicians.Conclusions. The results of this study enhance the current understanding of the career of a physician in medical organizations and its management. In addition, a number of applied issues accociated with career management improvement in medical organization can be solved.Conflict of interest: the authors declare no conflict of interest