Structure-from-Motion Approach for Characterization of Bioerosion Patterns Using UAV Imagery

The aim of this work is to evaluate the applicability of the 3D model obtained through Structure-from-Motion (SFM) from unmanned aerial vehicle (UAV) imagery, in order to characterize bioerosion patterns (i.e., cavities for roosting and nesting) caused by burrowing parrots on a cliff in Bahía Blanca, Argentina. The combined use of SFM-UAV technology was successfully applied for the 3D point cloud model reconstruction. The local point density, obtained by means of a sphere of radius equal to 0.5 m, reached a mean value of 9749, allowing to build a high-resolution model (0.013 m) for resolving fine spatial details in topography. To test the model, we compared it with another point cloud dataset which was created using a low cost do-it-yourself terrestrial laser scanner; the results showed that our georeferenced model had a good accuracy. In addition, an innovative method for the detection of the bioerosion features was implemented, through the processing of data provided by SFM like color and spatial coordinates (particularly the y coordinate). From the 3D model, we also derived topographic calculations such as slope angle and surface roughness, to get associations between the surface topography and bioerosion features.Fil: Genchi, Sibila Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Argentino de Oceanografía (i); Argentina. Universidad Nacional del Sur. Departamento de Geografía; ArgentinaFil: Vitale, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Argentino de Oceanografía (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; ArgentinaFil: Perillo, Gerardo Miguel E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Argentino de Oceanografía (i); Argentina. Universidad Nacional del Sur. Departamento de Geología; ArgentinaFil: Delrieux, Claudio Augusto. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Interaction between estuarine microphytobenthos and physical forcings: the role of atmospheric and sedimentary factors

The goal of this study was to analyze microbial mats and biofilms from the lower supratidal area of the Bahía Blanca estuary (Argentina), and explore their relationship with sediments and other physical forcings. Thirteen monthly sediment samples (uppermost 10 mm) were taken and their composition and abundance in microorganisms was determined by microscopy. Physical parameters (solar radiation and sediment temperature at -5 cm) were recorded with a frequency of 5 minutes by a coastal environmental monitoring station. Additionally, sediment grain size and moisture content were determined for distinct layers in the uppermost20 mm, and the rate of inundation of the supratidal area was estimated from tidal gauge measurements. There were significant seasonal differences in the biomass of the microphytobenthic groups considered (filamentous cyanobacteria and epipelic diatoms), with the former consistently making up >70% of the total biomass. The relationships between microphytobenthos and sediment temperature and solar radiation fitted to linear regressions, and consistently showed an inverse relationship between microphytobenthic abundance and either one of the physical parameters. The granulometric analysis revealed a unimodal composition of muddy sediments, which were vertically and spatially homogeneous; additionally, there were significant seasonal differences in water content loss with drying conditions prevailing in the summer. Several Microbially-Induced Sedimentary Structures (MISS) were identified in the supratidal zone such as shrinkage cracks, erosional pockets, gas domes, photosynthetic domes, mat chips and sieve-like surfaces. In contrast to studies from analogous environments in the Northern Hemisphere, we found reduced microphytobenthic biomass in summer, which were explained by increased evaporation/desiccation rates as a consequence of increased radiation, despite frequent tidal inundation. In conclusion, the observed density shifts in the benthic microbial communities are attributable to physical forcings dependent upon seasonal variations in interplaying factors such as sediment temperature, solar radiation and tidal inundation.Fil: Pan, Jeronimo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bournod, Constanza Naimé. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Argentino de Oceanografía (i); ArgentinaFil: Cuadrado, Diana Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Argentino de Oceanografía (i); Argentina. Universidad Nacional del Sur; ArgentinaFil: Vitale, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Argentino de Oceanografía (i); Argentina. Universidad Nacional del Sur; ArgentinaFil: Piccolo, Maria Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Argentino de Oceanografía (i); Argentina. Universidad Nacional del Sur; Argentin

The effects of extreme drought events on the morphometry of shallow lakes: Implications for sediment resuspension and littoral and pelagic zone distribution

Shallow lakes, because of their depth, are more vulnerable to the effects of wind and changes in precipitation and evaporation that deeper lakes and thus respond more dramatically to extreme climatic events, such as drought. The morphology of shallow lakes influences many of their physical, chemical, biological and sedimentological processes including sediment resuspension. Sediment resuspension can trigger undesired effects such as eutrophication, increase in turbidity, cyanobacterial blooms, and also affects the distribution and extent of the littoral and pelagic zones (habitat distribution) with potentially negative consequences on biodiversity and loss of native species. These problems are an increasing concern in the face of global warming. To understand how changes in lake' morphometry, triggered by extreme drought events influence sediment resuspension and habitat distribution, we studied four shallow lakes located in the southwest of the Argentinean Pampas. Each lake was characterized by its bathymetry, morphometric parameters (including area, shore development, dynamic ratio, critical depth), the spatial distribution of the littoral and pelagic areas, and the effect of the waves on sediment resuspension. We measured the Area and Shore development again during selected extreme drought periods identified through the Standardized Precipitation-Evapotranspiration Index. Then, for the given drought period, we calculated the extent and distribution of littoral and pelagic areas and the critical depth at which sediment resuspension occurred and then estimated the percentage of the lake that would be affected by it. We found that Pampean lakes are profoundly affected by sediment resuspension triggered by wind during extreme dry events. Droughts have different effects depending on lake morphology. Dry periods caused not only a decrease in water volume, but also modified the extension of littoral and pelagic zones and increased sediment resuspension. These results have significant implications for the preservation of these rich ecosystems, especially in the context of global warming.Fil: Seitz, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geología; ArgentinaFil: Facundo, Scordo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geografía y Turismo; Argentina. University of Nevada; Estados UnidosFil: Vitale, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; ArgentinaFil: Vélez, María I.. University of Saskatchewan; CanadáFil: Perillo, Gerardo Miguel E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geología; Argentin

Mapping Topobathymetry in a Shallow Tidal Environment Using Low-Cost Technology

Detailed knowledge of nearshore topography and bathymetry is required for a wide variety of purposes, including ecosystem protection, coastal management, and flood and erosion monitoring and research, among others. Both topography and bathymetry are usually studied separately; however, many scientific questions and challenges require an integrated approach. LiDAR technology is often the preferred data source for the generation of topobathymetric models, but because of its high cost, it is necessary to exploit other data sources. In this regard, the main goal of this study was to present a methodological proposal to generate a topobathymetric model, using low-cost unmanned platforms (unmanned aerial vehicle and unmanned surface vessel) in a very shallow/shallow and turbid tidal environment (Bahia Blanca estuary, Argentina). Moreover, a cross-analysis of the topobathymetric and the tide level data was conducted, to provide a classification of hydrogeomorphic zones. As a main result, a continuous terrain model was built, with a spatial resolution of approximately 0.08 m (topography) and 0.50 m (bathymetry). Concerning the structure from motion-derived topography, the accuracy gave a root mean square error of 0.09 m for the vertical plane. The best interpolated bathymetry (inverse distance weighting method), which was aligned to the topography (as reference), showed a root mean square error of 0.18 m (in average) and a mean absolute error of 0.05 m. The final topobathymetric model showed an adequate representation of the terrain, making it well suited for examining many landforms. This study helps to confirm the potential for remote sensing of shallow tidal environments by demonstrating how the data source heterogeneity can be exploited.Fil: Genchi, Sibila Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Geografía y Turismo; ArgentinaFil: Vitale, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geografía y Turismo; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; ArgentinaFil: Perillo, Gerardo Miguel E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geología; ArgentinaFil: Seitz, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geología; ArgentinaFil: Delrieux, Claudio Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; Argentin

Drivers of ecosystem metabolism in two managed shallow lakes with different salinity and trophic conditions: The Sauce Grande and La Salada Lakes (Argentina)

Understanding the drivers and how they affect ecosystem metabolism is essential for developing effective management policy and plans. In this study, net ecosystem production (NEP), ecosystem respiration (R), and gross primary production (GPP) rates were estimated in relation to physicochemical, hydrological, and meteorological variables in La Salada (LS) and Sauce Grande (SG), two shallow lakes located in an important agricultural region with water management. LS is a mesosaline, mesotrophic-eutrophic lake, whereas SG is a hyposaline and eutrophic lake. GPP and R showed daily and seasonal variations, with R exceeding GPP during most of the study period in both lakes. Net heterotrophic conditions prevailed during the study period (NEP LS: -1.1 mmol O2 m-2 day-1 and NEP SG: -1.25 mmol O2 m-2 day-1). From data analysis, the temperature, wind speed, and lake volume are the main drivers of ecosystem metabolism for both lakes. Despite the significant differences between the two lakes, the NEP values were similar. The different hydrological characteristics (endorheic vs. flushing lake) were crucial in explaining why the two different systems presented similar ecosystem metabolic rates, emphasizing the importance of water management.Fil: Alfonso, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; ArgentinaFil: Brendel, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Agronomía; ArgentinaFil: Vitale, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; ArgentinaFil: Seitz, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geología; ArgentinaFil: Piccolo, Maria Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geografía y Turismo; ArgentinaFil: Perillo, Gerardo Miguel E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geología; Argentin

Impacto de las olas de calor en el flujo de calor superficial latente y sensible y perspectivas de futuro para las lagunas someras basadas en modelos de cambio climático

De acuerdo con las proyecciones de los modelos climáticos, se espera a nivel mundial un aumento en la frecuencia e intensidad de las olas de calor. Este estudio analiza, por primera vez, el efecto de los eventos de olas de calor en los flujos de calor latente (LE) y calor sensible (H) en dos lagunas someras: Laguna La Salada (LS - 39°27′ S, 62°42′ W) y Laguna Sauce Grande (SG - 38°57′ S, 61°24′ W). La velocidad y dirección del viento, la humedad relativa, y las diferencias de temperatura entre el aire y el agua determinaron los cambios en LE y H. Los valores diarios de ambas variables fueron altamente fluctuantes. Los valores medios diarios de H variaron entre -309,4 y 200,5 W m-2 y entre -78,6 y 104,8 W m-2 en LS y SG, respectivamente. Los valores medios diarios de LE variaron entre -152 y 463,9 W m-2 y entre -59,2 y 360,1 W m-2 en LS y SG, respectivamente. Ambos flujos disminuyeron con el paso de eventos de olas de calor, presentando una gran amplitud en los valores. En días con olas de calor comparados con días regulares se registraron cambios de hasta 96% en la media diaria de LE y 671% en la media diaria de H en LS y cambios de hasta 25% en la media diaria de LE y 987% en la media diaria de H para SG. Finalmente, se analizó el futuro incremento de la temperatura del aire para ambas lagunas bajo dos escenarios de calentamiento global (RCP 4.5 y RCP 8.5), que permiten deducir mayores amplitudes de cambio en ambos flujos de calor. Estos resultados contribuyen al desarrollo de modelos para lagunas someras, y a las decisiones de manejo de los recursos hídricos en el futuro.According to model projections, increases in the frequency and intensity of heatwaves are expected all over the world. This study analyzed, for the first time, the effect of heatwaves events on long-term surface latent (LE) and sensible heat fluxes (H) from two shallow lakes: La Salada lake (LS-39°27′ S, 62°42′ W) and Sauce Grande lake (SG-38°57′ S, 61°24′ W). The main drivers of LE and H are wind speed and direction, relative humidity, and the difference between air and water temperature. We found that the daily values of both fluxes were highly fluctuating. Mean daily H values ranged between-309.4 to 200.5 W m-2 and-78.6 to 104.8 W m-2 in LS and SG, respectively. LE oscillated between-152 and 463.9 W m-2 and between-59.2 and 360.1 W m-2 in LS and SG, respectively. Both fluxes decreased with the passage of heatwaves events, presenting a high variation in its amplitude. Changes up to 96% in mean daily LE and 671% in mean daily H for LS and up to 25% in LE and 987% in H for SG were accounted in days with heatwaves respect to regular ones. We analyzed the air temperature increase for both lakes under future global warming scenarios (RCP 4.5 y RCP 8.5), expecting higher amplitudes in heat fluxes. These results contribute to the development of lake models, as well as to water resources management in the future.Fil: Alfonso, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; ArgentinaFil: Brendel, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Agronomía; ArgentinaFil: Vitale, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; ArgentinaFil: Piccolo, Maria Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geografía y Turismo; Argentin

Utilidad del monitoreo lagunar ambiental con boyas multiparamétricas en la región pampeana: Laguna La Barrancosa

Las lagunas de la región pampeana son ambientes naturales que poseen la particularidad de ?atraparnos? por diferentes razones. Quizás sea por la tranquilidad que trasmiten sus aguas, el sonido del oleaje, el silencio, su aire fresco y renovador, sus amaneceres, sus atardeceres, el sonido de algunas aves, el disfrute de la pesca o por el contacto con la naturaleza. Este libro es una invitación a emprender un viaje, recorrer un camino que nos lleve imaginariamente a una laguna, tomando como caso La Barrancosa, para visualizarla, conocerla, valorarla, protegerla, usarla y disfrutarla responsablemente. El objetivo es dar a conocer diferentes aspectos de las lagunas pampeanas con énfasis en La Barrancosa. Se tiende a que el lector sepa de su existencia, su dinámica, sus factores determinantes, sus bienes y servicios ecológicos, su fragilidad, su pertenencia e identificación con el paisaje folklórico pampeano, sus organismos constituyentes, sus relaciones tróficas, sus vínculos con el hombre actual y del pasado, en definitiva que sean consideradas un escenario propicio para lograr el acercamiento y respeto hacia la Naturaleza y sus diferentes formas de vida.Está conformado por 21 capítulos escritos por especialistas en temas sobre la limnología o aspectos asociados a este ambiente en particular. Los 50 autores de Destino: La Barrancosa. Una invitación a conocer lagunas pampeanas intentan trasmitir esa pasión por las lagunas y compartir conocimientos con un público amplio: docentes y estudiantes de distintos niveles educativos, científicos, productores agropecuarios, pescadores, prestadores turísticos, concesionarios de lagunas, funcionarios, ONGs ambientalistas y público en general.Fil: Alfonso, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; ArgentinaFil: Vitale, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; ArgentinaFil: Perillo, Gerardo Miguel E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; ArgentinaFil: Piccolo, Maria Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentin

Stem: associated features in tumor cells able to colonize secondary tumor sites

Osteosarcoma (OS), the most frequent bone tumor in pediatrics, presents critical clinical challenges in lung metastasis and chemoresistance emergence. Understanding OS switch into a metastatic phenotype and the interaction OS-stromal cells relevant in the new niche, would help in developing better diagnostic and therapeutic tools. In order to distinguish aspects that would allow OS cells to leave the bone niche and survive in a new tissue environment, we evaluated behavioral features acquired by OS cells with ability to establishsecondary tumor growth in the lungs, approaching the degree of differentiation, doxorubicin (doxo) exclusion and distribution properties and molecular signatures. Our results indicate that lung-colonizing OS cells diminished its osteoblastic potential while modified the intracellular localization of chemodrugs. In this way, doxo switched from a nuclear to a cytoplasmatic distribution in cells with lung colonizing ability (0,884±0,015 SAOS2;0,546±0,131 LM7). These features coincided with a higher level of expression of stemrelated genes and lower expression of differentiation-associated markers even at basal conditions in the metastatic cells. On the other hand, the higher osteogenic activity of OS cells with non-colonizing features was even reflected as a paracrine osteo-inductive effect. In addition, OS cells with high and low lung-colonizing capacities have opposite impact in mesenchymal stem cells (MSCs). Further, OS cells colonized-mouse lungs had a greater chemoattractive induction on MSCs. A major acquisition in tumor cells with metastatic features is a switch into a stem-like state that could favor their survival in the pulmonary niche, opening new possibilities for specific chemotherapeutic schemes. We provide new insights on OS cells differing in lung homing ability, with particular emphasis on multidrug resistance and interaction with MSC, which would impact in early diagnosis and therapeutic management.Fil: Valenzuela Alvarez, Matias Juan Pablo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Gutierrez, Luciana Mariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Guzman, Guido Benjamin. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Sordelli, Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Vitale, Daiana Luján. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Cantero, María José. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alaniz, Laura Daniela. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: García, Mariana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Risk, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional e Ingeniería Biomédica - Hospital Italiano. Instituto de Medicina Traslacional e Ingeniería Biomédica.- Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional e Ingeniería Biomédica; ArgentinaFil: Lazarowski, Alberto Jorge. Universidad de Buenos Aires; ArgentinaFil: Correa, Alejandro. No especifíca;Fil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaReunión Anual de Sociedades de BiocienciaMar del PLataArgentinaSociedad Argentina de Investigación ClínicaAsociación Argentina de Farmacología ExperimentalSociedad Argentina de BiologíaSociedad Argentina de ProtozoologíaAsociación Argentina de NanomedicinasAsociación Argentina de Ciencia y Tecnología de Animales de Laboratori

A novel method for genomic-enabled prediction of cultivars in new environments

IntroductionGenomic selection (GS) has gained global importance due to its potential to accelerate genetic progress and improve the efficiency of breeding programs.Objectives of the researchIn this research we proposed a method to improve the prediction accuracy of tested lines in new (untested) environments.Method-1The new method trained the model with a modified response variable (a difference of response variables) that decreases the lack of a non-stationary distribution between the training and testing and improved the prediction accuracy.Comparing new and conventional methodWe compared the prediction accuracy of the conventional genomic best linear unbiased prediction (GBLUP) model (M1) including (or not) genotype × environment interaction (GE) (M1_GE; M1_NO_GE) versus the proposed method (M2) on several data sets.Results and discussionThe gain in prediction accuracy of M2, versus M1_GE, M1_NO_GE in terms of Pearson´s correlation was of at least 4.3%, while in terms of percentage of top-yielding lines captured when was selected the 10% (Best10) and 20% (Best20) of lines was at least of 19.5%, while in terms of Normalized Root Mean Squared Error (NRMSE) was of at least of 42.29%

COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated