75 research outputs found
The effect of epidermal growth factor and IGF-I infusion on hepatic and renal expression of the IGF-system in adult female rats
Systemic administration of epidermal growth factor (EGF) in neonatal rats
results in reduced body weight gain and decreased circulating levels of
IGF-I, suggesting its involvement in EGF-induced growth retardation. We
investigated the effect of EGF and/or IGF-I administration for 7 days on
circulating IGF-I and IGFBP levels and hepatic and renal IGF-system mRNA
expression profiles in adult female rats. EGF administration (30
microg/rat/day) did not influence body weight, liver or kidney weight. In
contrast, IGF-I (400 microg/rat/day) and EGF/IGF-I administration
increased both body weight and kidney weight. Also, serum IGF-I and the 30
kDa IGFBPs (IGFBP-1 and -2) were significantly increased in these groups.
Serum IGFBP-3 levels increased in the IGF-I group along with increased
hepatic IGFBP-1 and -3 mRNA levels. In contrast, in the EGF administration
group serum IGFBP-3 levels were significantly decreased; however, the mRNA
levels remained unchanged. In the EGF/IGF-I administration group, serum
IGF-I and IGFBP-3 levels were significantly lowered when compared with the
IGF-I administration group. This was in contrast to the effect on kidney
weight increase that was identical for the IGF-I and EGF/IGF-I groups. The
decrease in serum IGFBP-3 was not reflected at the hepatic IGFBP-3 mRNA
level. IGFBP-3 expression might be regulated at a post-transcriptional
level although EGF induced IGFBP-3 proteolysis could not be demonstrated
in vitro. We conclude that EGF administration reduced serum IGFBP-3
whereas IGF-I administration increased the level of IGFBP-3 and IGF-I and
resulted in an increased body and kidney weight in adult female rats
The effect of epidermal growth factor and IGF-I infusion on hepatic and renal expression of the IGF-system in adult female rats
The red optical afterglow of GRB 030725
We present a photometric study of the optical counterpart of the
long-duration Gamma Ray Burst (GRB) 030725, which triggered the HETE FREGATE
and WXM instruments on July 25th, 2003, and lasted more than 160s. An optical
counterpart was identified at the Bronberg Observatory in South Africa about 7
hours after the burst occurred. The optical afterglow (OA) was observed between
4 and 15 days after the burst with the 1.54m Danish telescope at La Silla in
the V, Rc, and Ic bands. We fit a broken power law to the data and determine a
break time in the light curve between 16 hours and 4.7 days after the first
detection of the burst. The decay slope is alpha1 = -0.59 +0.59/-0.44 before
and alpha2 = -1.43 +/- 0.06 after the break. A bump may be present in the light
curve, only significant at the 2-sigma level, 13.9 days after the main burst.
The spectral slope of the OA, measured 12 days after the burst, is -2.9 +/- 0.6
, i.e. it falls in the extreme red end of the distribution of previous OA
spectral slopes. Observations of the field 8 months after the burst with the
EMMI instrument on the NTT telescope (La Silla) resulted in an upper limit of
Rc=24.7 mag for the host galaxy of GRB 030725. The OA of GRB 030725 was
discovered at a private, non-professional observatory and we point out that
with the current suite of gamma ray satellites, an effort to organize future
contributions of amateur observers may provide substantial help in GRB light
curve follow up efforts.Comment: Accepted for publication in A&A, 6 pages, 2 figure
On the Afterglow of the X-Ray Flash of July 23 2003: Photometric evidence for an off-axis Gamma-Ray Burst with an associated Supernova?
We present optical and near-infrared follow-up observations of the X-Ray
Flash (XRF) of July 23 2003. Our observations in the R-band cover the temporal
range from 4.2 h to 64 days after the high energy event. We also present the
results of multicolor imaging extending to the K-band on three epochs. The
lightcurve of the R-band afterglow the first week after the burst is similar to
the lightcurve for long duration Gamma-Ray Bursts (GRBs), i.e., a broken
power-law with a late time slope of alpha=-2.0 (F_nu propto t^alpha).
Furthermore, the spectral energy distribution (SED) has a power-law (F_nu
propto nu^beta) shape with slope beta=-1.0. However, the decay slope at t<1 day
is shallow, consistent with zero. This is in qualitative agreement with the
prediction that XRFs are off-axis classical GRBs. After the first week there is
a strong bump in the lightcurve, which peaks at around 16 days. The SED after
the peak becomes significantly redder. We discuss the possible interpretations
of this bump, and conclude that an underlying supernova is the most likely
explanation since no other model appears consistent with the evolution of the
SED. Finally, we present deep spectroscopy of the burst both in the afterglow
and in the bump phase. A firm upper limit of z=2.3 is placed on the redshift of
XRF030723 from the lack of Ly-alpha forest lines in the spectrum of the
afterglow. The lack of significant absorption and emission lines in either of
the two spectra excludes a spectroscopic redshift determination.Comment: 9 pages, 5 figures. Accepted for publication in Ap
Impact of maternal education on response to lifestyle interventions to reduce gestational weight gain: Individual participant data meta-Analysis
Objectives To identify if maternal educational attainment is a prognostic factor for gestational weight gain (GWG), and to determine the differential effects of lifestyle interventions (diet based, physical activity based or mixed approach) on GWG, stratified by educational attainment. Design Individual participant data meta-Analysis using the previously established International Weight Management in Pregnancy (i-WIP) Collaborative Group database (https://iwipgroup.wixsite.com/collaboration). Preferred Reporting Items for Systematic reviews and Meta-Analysis of Individual Participant Data Statement guidelines were followed. Data sources Major electronic databases, from inception to February 2017. Eligibility criteria Randomised controlled trials on diet and physical activity-based interventions in pregnancy. Maternal educational attainment was required for inclusion and was categorised as higher education ( 65tertiary) or lower education ( 64secondary). Risk of bias Cochrane risk of bias tool was used. Data synthesis Principle measures of effect were OR and regression coefficient. Results Of the 36 randomised controlled trials in the i-WIP database, 21 trials and 5183 pregnant women were included. Women with lower educational attainment had an increased risk of excessive (OR 1.182; 95% CI 1.008 to 1.385, p =0.039) and inadequate weight gain (OR 1.284; 95% CI 1.045 to 1.577, p =0.017). Among women with lower education, diet basedinterventions reduced risk of excessive weight gain (OR 0.515; 95% CI 0.339 to 0.785, p = 0.002) and inadequate weight gain (OR 0.504; 95% CI 0.288 to 0.884, p=0.017), and reduced kg/week gain (B-0.055; 95% CI-0.098 to-0.012, p=0.012). Mixed interventions reduced risk of excessive weight gain for women with lower education (OR 0.735; 95% CI 0.561 to 0.963, p=0.026). Among women with high education, diet based interventions reduced risk of excessive weight gain (OR 0.609; 95% CI 0.437 to 0.849, p=0.003), and mixed interventions reduced kg/week gain (B-0.053; 95% CI-0.069 to-0.037,p<0.001). Physical activity based interventions did not impact GWG when stratified by education. Conclusions Pregnant women with lower education are at an increased risk of excessive and inadequate GWG. Diet based interventions seem the most appropriate choice for these women, and additional support through mixed interventions may also be beneficial
Одноколейные тракторно-ледяные дороги: учебное пособие для лесотехнических вузов
Книга содержит описание конструкций однополозных тракторных саней, расчет основных деталей саней, краткие технические условия проектирования одноколейных тракторно-ледяных дорог, правила постройки и эксплуатации ледяных дорог и основы организации тракторного хозяйства на базе одноколейных ледяных дорог. Книга предназначена в качестве учебного пособия для лесотехнических вузов, но может также служить практическим пособием и для высшего технического персонала лесозаготовительных предприятий Наркомлеса СССР.0|7|Предисловие [c. 7]0|8|Введение [c. 8]0|11|Возникновение и развитие конструкции однополозных саней [c. 11]1|11|Первые опыты [c. 11]1|12|Принцип работы одноколейной ледяной дороги и теоретические основания проектирования однополозных саней [c. 12]1|17|Конструкция первых однополозных саней [c. 17]1|17|Однополозные сани Востокостальлеса [c. 17]1|19|Одкополозные сани ЦНИИМЭ, модель Б [c. 19]1|21|Однополозные сани на базе поковок тракторных двухполозных саней модели Д [c. 21]1|22|Однополозные сани Я. И. Гинзбурга модели 1939 г. [c. 22]1|33|Однополозные сани ГЗЯ-2 [c. 33]1|39|Варианты соединения коника с полозом [c. 39]1|39|Модернизированные однополозные сани на базе поковок саней модели Свердлеса и Востокостальлеса [c. 39]1|44|Бескониковые однополозные сани конструкции СибНИИЛХЭ [c. 44]1|46|Буферно-прицепные устройства трактора конструкции УЛТИ, Сотринского мехлесопункта и Стройлеспроекта [c. 46]1|48|Автоматическая сцепка тракторных саней [c. 48]1|49|Рама для перевозки коротья на однополозных санях [c. 49]1|51|Расчет саней [c. 51]1|51|Расчет полоза [c. 51]1|58|О форме подрезов [c. 58]0|61|Постройка одноколейных ледяных дорог [c. 61]1|61|Условия применения, сырьевая база и порядок оформления строительства [c. 61]1|62|Технические условия проектирования одноколейных ледяных дорог [c. 62]1|72|Изыскания трасс одноколейных ледяных дорог [c. 72]1|73|Строительные работы на одноколейных ледяных дорогах [c. 73]1|85|Дорожные орудия для строительства одноколейных ледяных дорог [c. 85]1|91|Цистерны для поливки ледяной дороги [c. 91]1|91|Насосные станции [c. 91]0|95|Эксплуатация ледяных дорог [c. 95]1|95|Техническая характеристика тяговых машин [c. 95]1|107|Эксплуатация газогенераторных тракторов на лесовывозке по ледяным дорогам [c. 107]1|115|Правила вождения поездов [c. 115]1|117|Формирование состава и маневры [c. 117]1|117|Содержание и ремонт пути ледяной дороги [c. 117]1|119|Техника безопасности при вывозке леса по тракторным ледяным дорогам [c. 119]1|121|Основные правила по технике безопасности для тракторного лесотранспорта [c. 121]0|123|Приложения [c. 123]1|123|Детали однополозных саней ГЗЯ-1 [c. 123]1|136|Детали модернизированных однополозных саней на базе поковок саней Свердллеса [c. 136]1|141|Краткая техническая характеристика гусеничных тракторов Челябинского тракторного завода [c. 141]0|143|Оглавление [c. 143
Transferable kriging machine learning models for the multipolar electrostatics of helical deca-alanine
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