Aliatges metàl·lics per a implantaments ossis i articulars

Els materials metàl•lics són amplament utilitzats per a pròtesis i ortesis, així com en el tractament de fractures òssies. L'objectiu del present treball és de resumir les característiques més importants dels aliatges metàl•lics més utilitzats en implantaments ossis i articulars, i discutir els requeriments de compatibilitat mecànica i la biocompatibilitat que han de complir aquests materials. Mereixen una consideració especial la corrosió, com a principal factor en la bioactivitat de l'aliatge, i la fatiga, com a causa principal de ruptura. Finalment, hom presenta uns quants exemples d'assaigs i anàlisis d'unes quantes plaques d'osteosíntesi.Metallic materials are extensively used in prostheses and ortheses, and in the treatment of bone fractures. The aim of the present work is to summarise the features of the metallic alloys most commonly used in bone and joint implants, and to discuss the mechanical compatibility and bio-compatibility requirements placed upon such materials. Corrosion, as the main factor in the bioactivity of the alloy and fatigue, as the main cause of failure, are specially considered. Finally, some examples on the testing and the analysis of a few ostheosynthesis plates are presented

Chelating properties of tripeptide-9 citrulline

Tripeptide-9 Citrulline (INCI name) is a peptide with skin care properties, used for cosmetic applications. In order to elucidate its mechanism of action in the chemical pathways that involve metal ions, its ability to complex such ions was investigated using spectrophotometrical, electrochemical and electrophoretical techniques. The obtained results using Cu(II) as metal ion were consistent with the formation of a complex between Tripeptide-9 Citrulline andCu(II). Cyclic voltammetry revealed a significant changein the electrochemical potentials. In-vitro electrophoretic studies served as a proof of concept that Tripeptide-9 Citrullinemay protect DNA from radical degradation induced by the Fenton reaction

Propietats de coordinació de Tripeptide-9-citrulline

Tripeptide-9 Citrulline (INCI name) is a peptide with skin care properties, used for cosmetic applications. In order to elucidate its mechanism of action in the chemical pathways that involve metal ions, its ability to complex such ions was investigated using spectrophotometrical, electrochemical and electrophoretical techniques. The obtained results using Cu(II) as metal ion were consistent with the formation of a complex between Tripeptide-9 Citrulline and Cu(II). Cyclic voltammetry revealed a significant change in the electrochemical potentials. In-vitro electrophoretic studies served as a proof of concept that Tripeptide-9 Citrulline may protect DNA from radical degradation induced by the Fenton reaction.Tripeptide-9-citrulline (nombre INCI) es un péptido para el cuidado de la piel, usado en aplicaciones cosméticas. Para elucidar su mecanismo de acción en aquellas vías químicas que implican iones metálicos, se ha estudiado su capacidad para formar complejos metálicos. Dicho estudio se ha llevado a cabo utilizando técnicas espectrofotométricas, electroquímicas y electroforéticas. Los resultados obtenidos, usando Cu (II) como ión metálico, son consistentes con la formación de un complejo entre Tripeptide-9-citrulline y el ion metálico. La voltametría cíclica ha revelado un cambio significativo en los potenciales electroquímicos. Finalmente se ha demostrado mediante experimentos de electroforéticos que Tripeptide-9-citrulline podría proteger el ADN de la degradación inducida por los radicales producidos en la reacción de Fenton.Tripeptide-9-citrulline (Nom INCI) és un pèptid usat en aplicacions cosmètiques que tenen cura de la pell. Per a elucidar el seu mecanisme d’acció en aquelles vies químiques que involucren ions metàl·lics, s‘ha estudiat la seva capacitat per a format complexos metàl·lics. Aquest estudi s’ha dut a terme utilizant tècniques espectrofotomètriques, electroquímiques i electroforètiques. Els resultats obtinguts, emprant (II) com a ió metàl·lic, són consistents amb la formació d’un complex entre Tripeptide-9-citrulline i el ió metàl·lic. La voltametria cíclica revela un canvi significatiu entre els potencials electroquímics. Finalment, s’ha demostrat mitjançant experiments electroforètics que Tripeptide-9-citrulline podria protegir l’ADN de la degradació induïda pels radicals produïts en la reacció de Fenton

An Ouzo emulsion of toluene in water characterized by NMR diffusometry and static multiple light scattering

An Ouzo emulsion is an emulsion that is formed spontaneously by adding water to a system comprising a hydrophobic substance (like anethole in the Ouzo beverage), a water-miscible solvent and (optionally) water. Formation of such an emulsion does not require the use of surfactants, dispersing agents, or mechanical agitation. In this work, Ouzo emulsions were prepared from the ternary mixture toluene-ethanol-water and the emulsion stability was studied by a combination of two techniques: static multiple light scattering and NMR diffusometry. A bimodal distribution of the droplets was found. The light scattering technique revealed the presence of large drops, several micrometer in size. NMR measurements confirmed the large drops but also showed the additional presence of droplets of the order of 100 nm in diameter. The distribution of toluene between the three environments (i) large drops, (ii) small droplets, and (iii) the continuous ethanol-water phase could also be assessed. It was found that addition of an anionic surfactant to the system yielded an improved dispersed system, i.e., more toluene was present as small droplets and less toluene was dissolved in the ethanol-water phase; however the presence of the amphiphile reduced the emulsion stability. (C) 2016 Elsevier B.V. All rights reserved

How to manage digitization programs in museums

VoRSUNY OneontaCooperstown Graduate Program (Museum Studies)N/

Differentiating Acute Interstitial Nephritis From Immune Checkpoint Inhibitors From Other Causes

Immune checkpoint inhibitors (ICIs) have significantly improved outcomes for patients with neoplasms in advanced stages. On the other hand, ICIs have immune-related adverse events. These adverse events affect mostly other organs than the kidney, such as skin or gastrointestinal tract. The incidence of nephrotoxicity with monotherapy with any ICI is about 2%, which increases to 5% in combination therapy. Acute tubulointerstitial nephritis (AIN) is the most common pattern of kidney damage related to ICIs. Globally, without considering ICI nephrotoxicity, AIN is estimated to account for 15% to 20% of cases of acute kidney injury (AKI). This is crucial because patients who are treated with ICIs, may also be taking other drugs that potentially cause AIN, and therefore, knowing the particularities about ICI-related AIN could be helpful in clinical practice to better understand the phenotypic differences between the 2 types of AIN. In addition, several studies have now shown that being on proton pump inhibitors is a risk factor for AIN from ICI therapy

Vitality, Language Use, and Life Satisfaction : A Study of Bilingual Hungarian Adolescents Living in Romania

This study examined the relationship between objective and subjective vitality, in-group language use, and life satisfaction among two groups of bilingual Hungarians adolescents living in Romania: a low objective vitality group from Cluj-Napoca/Kolozsvar, where Hungarians are the demographic minority, and a high objective vitality group from Sfantu Gheorghe/Sepsiszentgyorgy, where Hungarians are the demographic majority. Consistent with predictions, the high objective vitality group reported higher subjective Hungarian vitality, lower subjective Romanian vitality, more frequent use of the Hungarian language, and higher life satisfaction, compared with the low objective vitality group. The effects of objective vitality on language use were partially mediated by subjective Romanian (but not Hungarian) vitality. Conversely, the effects of objective vitality on life satisfaction were fully mediated by subjective Hungarian (but not Romanian) vitality.Peer reviewe