2,380 research outputs found
The entangling side of the Unruh-Hawking effect
We show that the Unruh effect can create net quantum entanglement between
inertial and accelerated observers depending on the choice of the inertial
state. This striking result banishes the extended belief that the Unruh effect
can only destroy entanglement and furthermore provides a new and unexpected
source for finding experimental evidence of the Unruh and Hawking effects.Comment: 4 pages, 4 figures. Added Journal referenc
Time singularities of correlators from Dirichlet conditions in AdS/CFT
Within AdS/CFT, we establish a general procedure for obtaining the leading
singularity of two-point correlators involving operator insertions at different
times. The procedure obtained is applied to operators dual to a scalar field
which satisfies Dirichlet boundary conditions on an arbitrary time-like surface
in the bulk. We determine how the Dirichlet boundary conditions influence the
singularity structure of the field theory correlation functions. New
singularities appear at boundary points connected by null geodesics bouncing
between the Dirichlet surface and the boundary. We propose that their
appearance can be interpreted as due to a non-local double trace deformation of
the dual field theory, in which the two insertions of the operator are
separated in time. The procedure developed in this paper provides a technical
tool which may prove useful in view of describing holographic thermalization
using gravitational collapse in AdS space.Comment: 30 pages, 3 figures. Version as in JHE
Identification of metabolomics biomarkers for type 2 diabetes: triangulating evidence from longitudinal and Mendelian randomization analyses
Holographic Evolution of Entanglement Entropy
We study the evolution of entanglement entropy in a 2-dimensional
equilibration process that has a holographic description in terms of a Vaidya
geometry. It models a unitary evolution in which the field theory starts in a
pure state, its vacuum, and undergoes a perturbation that brings it far from
equilibrium. The entanglement entropy in this set up provides a measurement of
the quantum entanglement in the system. Using holographic techniques we recover
the same result obtained before from the study of processes triggered by a
sudden change in a parameter of the hamiltonian, known as quantum quenches.
Namely, entanglement in 2-dimensional conformal field theories propagates with
velocity v^2=1. Both in quantum quenches and in the Vaidya model equilibration
is only achieved at the local level. Remarkably, the holographic derivation of
this last fact requires information from behind the apparent horizon generated
in the process of gravitational collapse described by the Vaidya geometry. In
the early stages of the evolution the apparent horizon seems however to play no
relevant role with regard to the entanglement entropy. We speculate on the
possibility of deriving a thermalization time for occupation numbers from our
analysis.Comment: 26 pages, 10 figure
The effect of intervertebral cartilage on neutral posture and range of motion in the necks of sauropod dinosaurs
The necks of sauropod dinosaurs were a key factor in their evolution. The habitual posture and range of motion of these necks has been controversial, and computer-aided studies have argued for an obligatory sub-horizontal pose. However, such studies are compromised by their failure to take into account the important role of intervertebral cartilage. This cartilage takes very different forms in different animals. Mammals and crocodilians have intervertebral discs, while birds have synovial joints in their necks. The form and thickness of cartilage varies significantly even among closely related taxa. We cannot yet tell whether the neck joints of sauropods more closely resembled those of birds or mammals. Inspection of CT scans showed cartilage:bone ratios of 4.5% for Sauroposeidon and about 20% and 15% for two juvenile Apatosaurus individuals. In extant animals, this ratio varied from 2.59% for the rhea to 24% for a juvenile giraffe. It is not yet possible to disentangle ontogenetic and taxonomic signals, but mammal cartilage is generally three times as thick as that of birds. Our most detailed work, on a turkey, yielded a cartilage:bone ratio of 4.56%. Articular cartilage also added 11% to the length of the turkey's zygapophyseal facets. Simple image manipulation suggests that incorporating 4.56% of neck cartilage into an intervertebral joint of a turkey raises neutral posture by 15°. If this were also true of sauropods, the true neutral pose of the neck would be much higher than has been depicted. An additional 11% of zygapophyseal facet length translates to 11% more range of motion at each joint. More precise quantitative results must await detailed modelling. In summary, including cartilage in our models of sauropod necks shows that they were longer, more elevated and more flexible than previously recognised
FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream signalling. Here we investigated how FAK regulates signalling resulting from the overexpression of the RTKs RET and EGFR. FAK suppressed RTKs signalling in Drosophila melanogaster epithelia by impairing MAPK pathway. This regulation was also observed in MDA-MB-231 human breast cancer cells, suggesting it is a conserved phenomenon in humans. Mechanistically, FAK reduced receptor recycling into the plasma membrane, which resulted in lower MAPK activation. Conversely, increasing the membrane pool of the receptor increased MAPK pathway signalling. FAK is widely considered as a therapeutic target in cancer biology; however, it also has tumour suppressor properties in some contexts. Therefore, the FAK-mediated negative regulation of RTK/MAPK signalling described here may have potential implications in the designing of therapy strategies for RTK-driven tumours
Anisotropic Drag Force from 4D Kerr-AdS Black Holes
Using AdS/CFT we investigate the effect of angular-momentum-induced
anisotropy on the instantaneous drag force of a heavy quark. The dual
description is that of a string moving in the background of a Kerr-AdS black
holes. The system exhibits the expected focussing of jets towards the impact
parameter plane. We put forward that we can use the connection between this
focussing behavior and the angular momentum induced pressure gradient to
extrapolate the pressure gradient correction to the drag force that can be used
for transverse elliptic flow in realistic RHIC. The result is recognizable as a
relativistic pressure gradient force.Comment: 22 pages and 4 figure
Extrinsic and intrinsic determinants of nerve regeneration
After central nervous system (CNS) injury axons fail to regenerate often leading to persistent neurologic deficit although injured peripheral nervous system (PNS) axons mount a robust regenerative response that may lead to functional recovery. Some of the failures of CNS regeneration arise from the many glial-based inhibitory molecules found in the injured CNS, whereas the intrinsic regenerative potential of some CNS neurons is actively curtailed during CNS maturation and limited after injury. In this review, the molecular basis for extrinsic and intrinsic modulation of axon regeneration within the nervous system is evaluated. A more complete understanding of the factors limiting axonal regeneration will provide a rational basis, which is used to develop improved treatments for nervous system injury
Entanglement distribution and quantum discord
Establishing entanglement between distant parties is one of the most
important problems of quantum technology, since long-distance entanglement is
an essential part of such fundamental tasks as quantum cryptography or quantum
teleportation. In this lecture we review basic properties of entanglement and
quantum discord, and discuss recent results on entanglement distribution and
the role of quantum discord therein. We also review entanglement distribution
with separable states, and discuss important problems which still remain open.
One such open problem is a possible advantage of indirect entanglement
distribution, when compared to direct distribution protocols.Comment: 7 pages, 2 figures, contribution to "Lectures on general quantum
correlations and their applications", edited by Felipe Fanchini, Diogo
Soares-Pinto, and Gerardo Adess
Holographic phase diagram of quark-gluon plasma formed in heavy-ions collisions
The phase diagram of quark gluon plasma (QGP) formed at a very early stage
just after the heavy ion collision is obtained by using a holographic dual
model for the heavy ion collision. In this dual model colliding ions are
described by the charged shock gravitational waves. Points on the phase diagram
correspond to the QGP or hadronic matter with given temperatures and chemical
potentials. The phase of QGP in dual terms is related to the case when the
collision of shock waves leads to formation of trapped surface. Hadronic matter
and other confined states correspond to the absence of trapped surface after
collision.
Multiplicity of the ion collision process is estimated in the dual language
as area of the trapped surface. We show that a non-zero chemical potential
reduces the multiplicity. To plot the phase diagram we use two different dual
models of colliding ions, the point and the wall shock waves, and find
qualitative agreement of the results.Comment: 33 pages, 14 figures, typos correcte
- …