Redefining bilingualism as a spectrum of experiences that differentially affect brain structure and function

Learning and using an additional language is shown to have an impact on the structure and function of the brain, including in regions involved in cognitive control and the connections between them. However, the available evidence remains variable in terms of the localization, extent and trajectory of these effects. Variability likely stems from the fact that bilingualism has been routinely operationalized as a categorical variable (bilingual/monolingual), whereas it is a complex and dynamic experience with a number of potentially deterministic factors affecting neural plasticity. Here we present the first study investigating the combined effects of experience-based factors (EBFs) in bilingual language use on brain structure and functional connectivity. EBFs include an array of measures of everyday usage of a second language in different types of immersive settings (e.g., amount of use in social settings). Analyses reveal specific adaptations in the brain, both structural and functional, correlated to individual EBFs and their combined effects. Taken together the data show that the brain adapts to be maximally efficient in the processing and control of two languages, although modulated ultimately by individual language experience

Effects of carbamazepine and lamotrigine on functional magnetic resonance imaging cognitive networks.

OBJECTIVE: To investigate the effects of sodium channel-blocking antiepileptic drugs (AEDs) on functional magnetic resonance imaging (fMRI) language network activations in patients with focal epilepsy. METHODS: In a retrospective study, we identified patients who were treated at the time of language fMRI scanning with either carbamazepine (CBZ; n = 42) or lamotrigine (LTG; n = 42), but not another sodium channel-blocking AED. We propensity-matched 42 patients taking levetiracetam (LEV) as "patient-controls" and included further 42 age- and gender-matched healthy controls. After controlling for age, age at onset of epilepsy, gender, and antiepileptic comedications, we compared verbal fluency fMRI activations between groups and out-of-scanner psychometric measures of verbal fluency. RESULTS: Patients on CBZ performed less well on a verbal fluency tests than those taking LTG or LEV. Compared to either LEV-treated patients or controls, patients taking CBZ showed decreased activations in left inferior frontal gyrus and patients on LTG showed abnormal deactivations in frontal and parietal default mode areas. All patient groups showed fewer activations in the putamen bilaterally compared to controls. In a post hoc analysis, out-of-scanner fluency scores correlated positively with left putamen activation. SIGNIFICANCE: Our study provides evidence of AED effects on the functional neuroanatomy of language, which might explain subtle language deficits in patients taking otherwise well-tolerated sodium channel-blocking agents. Patients on CBZ showed dysfunctional frontal activation and more pronounced impairment of performance than patients taking LTG, which was associated only with failure to deactivate task-negative networks. As previously shown for working memory, LEV treatment did not affect functional language networks

Dietary α‐Linolenic Acid, Marine ω‐3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study

Background: Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results: We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56–0.92) for all‐cause mortality and 0.95 (95% CI 0.58–1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67–1.05) for all‐cause mortality, 0.61 (95% CI 0.39–0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29–0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22–1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45–0.87]). Conclusions: In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids. Clinical Trial Registration URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639

Bilingualism and the Semantic-Conceptual Interface: The Influence of Language On Categorization

© Cambridge University Press 2016. These studies address monolinguals\u27 and bilinguals\u27 processing of categories, in order to examine the relationship between concepts and linguistically encoded classes. We focus on languages that differ in their conceptual lexicalization and breadth of application, where one language has a single word (e.g., dedo in Spanish) that corresponds to two words in another language (e.g., English finger and toe). Categories differed across types of semantics-concept mappings, from \u27classical\u27 cases, involving members close in the conceptual space, to \u27homonyms\u27, involving conceptually distant items. Bilingual Catalan speakers, and English and Spanish monolinguals judged whether objects were \u27like\u27 an initial referent presented either with or without a label. Scores were highest in classical categories, lowest in homonyms; higher in narrow than wide categories; and better in labeled than unlabeled cases. Bilinguals outperformed monolinguals in judgments that conformed with their language, especially in wide categories. We discuss implications for the semantics-cognition interface and bilingualism

Bilingualism and the semantic-conceptual interface: the influence of language on categorization

© Cambridge University Press 2016. These studies address monolinguals\u27 and bilinguals\u27 processing of categories, in order to examine the relationship between concepts and linguistically encoded classes. We focus on languages that differ in their conceptual lexicalization and breadth of application, where one language has a single word (e.g., dedo in Spanish) that corresponds to two words in another language (e.g., English finger and toe). Categories differed across types of semantics-concept mappings, from \u27classical\u27 cases, involving members close in the conceptual space, to \u27homonyms\u27, involving conceptually distant items. Bilingual Catalan speakers, and English and Spanish monolinguals judged whether objects were \u27like\u27 an initial referent presented either with or without a label. Scores were highest in classical categories, lowest in homonyms; higher in narrow than wide categories; and better in labeled than unlabeled cases. Bilinguals outperformed monolinguals in judgments that conformed with their language, especially in wide categories. We discuss implications for the semantics-cognition interface and bilingualism