Influence of Rat Strain and Arthritogen on Actions of Gold Drugs in Adjuvant-Induced Polyarthritis

The article examines the effects of aurothiomalate (ATM) and auranofin (AF) on adjuvant-induced polyarthritis and serum gold levels in three different strains of rats

Interactions between vaccinia virus and sensitized macrophages in vitro

The action of peritoneal exudate cells (PEC) from normal and vaccinia virus infected mice on infectious vaccinia virus particles was investigatedin vitro. PEC from immune mice showed a significantly higher infectivity titre reduction (virus clearance, VC) than normal cells. This effect could be clearly attributed to the macrophage. Vaccinia virus multiplied in PEC from normal animals while there was no virus propagation in cells from immunized mice. The release of adsorbed or engulfed virus was reduced significantly in PEC from immunized animals. Anti-vaccinia-antibodies seem to activate normal macrophages to increased virus clearance. This stimulating effect was demonstrable only in the IgG fraction of the antiserum. The activity of macrophages from mice injected three times over a period of 14 days with vaccinia virus could be entirely blocked with anti-mouse-IgG, while PEC from mice injected one time six days previously were not inhibited

Comparison of ankle and subtalar joint complex range of motion during barefoot walking and walking in Masai Barefoot Technology sandals

<p>Abstract</p> <p>Background</p> <p>Masai Barefoot Technology (MBT, Switzerland) produce footwear which they claim simulate walking barefoot on soft undulating ground. This paper reports an investigation into the effect of MBT sandals on the motion of the ankle and subtalar joint complex during walking.</p> <p>Methods</p> <p>Range of motion data was collected in the sagittal, frontal and transverse plane from the ankle and subtalar joint complex from 32 asymptomatic subjects using the CODA MPX30 motion analysis system during both barefoot walking and walking in the MBT sandal. Shod and un-shod data were compared using the Wilcoxon signed ranks test.</p> <p>Results</p> <p>A significantly greater range of motion in the frontal and sagittal planes was recorded when walking in the MBT sandal (p = 0.031, and p = 0.015 respectively). In the transverse plane, no significant difference was found (p = 0.470).</p> <p>Conclusions</p> <p>MBT sandals increase the range of motion of the ankle and subtalar joint complex in the frontal and sagittal planes. MBT footwear could therefore have a role to play in the management of musculoskeletal disorders where an increase in frontal and sagittal plane range of motion is desirable.</p

Ursinus College Alumni Journal, March 1954

President\u27s page • Dr. Gaylord P. Harnwell to speak at commencement • Ursinus confers honorary degree on Dr. James Wagner • William S. Pettit named Dean of Ursinus College • Prospective students entertained at Ursinus • May queen 1954 • Annual Messiah sung by largest chorus • Charles Roberts makes first 1954 loyalty fund report • Evelyn Glazier Henzel candidate for state legislature • Ursinus places nineteenth in mathematical competition • Lloyd Wood candidate for nomination of governor • Pre-meds enjoy hospital tours with Dr. Tornetta, \u2738 • Ursinus Women\u27s Club sets important spring dates • Watch for news of your Ursinus regional group spring meeting • Meeting of the Washington alumni on April 29 • Harrisburg-Hershey to organize • Berks Co. alumni dinner April 21 • Floyd Justice president of Philadelphia alumni • New York meeting on May 5 • Lehigh Valley dinner April 29 • Don\u27t miss Alumni Day - it\u27s May 29 • Be sure to vote for your alumni officers! • Watch for your ballot in April • Sports review • Mermaids open season with Drexel • Best football record in twenty years • Basketball belles take opener 51-21 • Coach Gurzynski reviews 1954 track prospects • Coach Spangler has hustling basketball squad • Basketball and hilarity at alumni-varsity game • Wrestling captain • Wrestling resume • Doc Baker reviews the 1953 soccer season • Hockey players Merrifield and Price honored • A day with the Dean of Women at Ursinus • News about ourselves • Ziegler awarded air medal • Engagements • Weddings • Births • Necrology • Carters enjoy life in Coloradohttps://digitalcommons.ursinus.edu/alumnijournal/1050/thumbnail.jp

Ursinus College Alumni Journal, November 1954

Two new preceptresses join administrative staff • Ursinus freshman honored by school group • Ursinus college evening school registration increases • Ursinus faculty member presents TV program • Three new members join the Ursinus faculty • Eight-week summer session at Ursinus • 1954-55 academic year opens with 685 students • Williams named dean at Buena Vista College • South Jersey alumni group holds annual dinner dance • Alumni booster group organizes • McKee named dean at New York University • Ursinus colony at University of Delaware • Dr. Robert McAllister directs polio tests • Bunny Harshaw Vosters \u2740 Middle States tennis champion • Dr. Cornelius Weygandt honored by Dr. Wm. J. Phillips • Christian education in India • College supply store under new management • Sports review • 1954 soccer prospects • Women\u27s varsity hockey • Ursinus women\u27s alumni hockey team plays Irish touring team • Ursinus 1954 football squad • Alumni give over $20,000 • Irene Heinly, class secretary explains the success of the class of 1911 • 1954 loyalty fund report • Mr. and Mrs. Kenneth Reinhart attribute the success of \u2749 to the aid of the vice chairmen • Report of 1954 loyalty fund campaign • Contributors for the 1954 loyalty fund campaign • UC Messiah chorus largest in history • Curtain Club plans fall production • News about ourselves • Engagements • Weddings • Births • Necrologyhttps://digitalcommons.ursinus.edu/alumnijournal/1051/thumbnail.jp

Crustal constraint through complete model space screening for diverse geophysical datasets facilitated by emulation

Deep crustal constraint is often carried out using deterministic inverse methods, sometimes using seismic refraction, gravity and electromagnetic datasets in a complementary or “joint” scheme. With increasingly powerful parallel computer systems it is now possible to apply joint inversion schemes to derive an optimum model from diverse input data. These methods are highly effective where the uncertainty in the system is small. However, given the complex nature of these schemes it is often difficult to discern the uniqueness of the output model given the noise in the data, and the application of necessary regularization and weighting in the inversion process means that the extent of user prejudice pertaining to the final result may be unclear. We can rigorously address the subject of uncertainty using standard statistical tools but these methods also become less feasible if the prior model space is large or the forward simulations are computationally expensive. We present a simple Monte Carlo scheme to screen model space in a fully joint fashion, in which we replace the forward simulation with a fast and uncertainty-calibrated mathematical function, or emulator. This emulator is used as a proxy to run the very large number of models necessary to fully explore the plausible model space. We develop the method using a simple synthetic dataset then demonstrate its use on a joint data set comprising first-arrival seismic refraction, MT and scalar gravity data over a diapiric salt body. This study demonstrates both the value of a forward Monte Carlo approach (as distinct from a search-based or conventional inverse approach) in incorporating all kinds of uncertainty in the modelling process, exploring the entire model space, and shows the potential value of applying emulator technology throughout geophysics. Though the target here is relatively shallow, the methodology can be readily extended to address the whole crust

The Influence of Prednisolone (PRED) and Methotrexate (MTX) on the Cell and Connective Tissue Content of Subcutaneously Implanted Polyurethane Sponges in Rats

Findings indicate that prednislone and methotrexate have profound effects on the cellular events of acute and chronic inflammation, and influence the synthesis or degradation of connective tissue macromolecules at certain stages of the inflammatory process

Nutritional management of children with cerebral palsy: a practical guide

Peer reviewedFinal Published versio

Temporomandibular Joint Disorder Complaints in Tinnitus: Further Hints for a Putative Tinnitus Subtype

OBJECTIVE: Tinnitus is considered to be highly heterogeneous with respect to its etiology, its comorbidities and the response to specific interventions. Subtyping is recommended, but it remains to be determined which criteria are useful, since it has not yet been clearly demonstrated whether and to which extent etiologic factors, comorbid states and interventional response are related to each other and are thus applicable for subtyping tinnitus. Analyzing the Tinnitus Research Initiative Database we differentiated patients according to presence or absence of comorbid temporomandibular joint (TMJ) disorder complaints and compared the two groups with respect to etiologic factors. METHODS: 1204 Tinnitus patients from the Tinnitus Research Initiative (TRI) Database with and without subjective TMJ complaints were compared with respect to demographic, tinnitus and audiological characteristics, questionnaires, and numeric ratings. Data were analysed according to a predefined statistical analysis plan. RESULTS: Tinnitus patients with TMJ complaints (22% of the whole group) were significantly younger, had a lower age at tinnitus onset, and were more frequently female. They could modulate or mask their tinnitus more frequently by somatic maneuvers and by music or sound stimulation. Groups did not significantly differ for tinnitus duration, type of onset (gradual/abrupt), onset related events (whiplash etc.), character (pulsatile or not), hyperacusis, hearing impairment, tinnitus distress, depression, quality of life and subjective ratings (loudness etc.). CONCLUSION: Replicating previous work in tinnitus patients with TMJ complaints, classical risk factors for tinnitus like older age and male gender are less relevant in tinnitus patients with TMJ complaints. By demonstrating group differences for modulation of tinnitus by movements and sounds our data further support the notion that tinnitus with TMJ complaints represents a subgroup of tinnitus with clinical features that are highly relevant for specific therapeutic management

Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo

The ability of 5-aminolaevulinic acid and some of its esterified derivatives to induce porphyrin accumulation has been examined in CaNT murine mammary carcinoma cells growing in culture and as tumours in vivo. Topical or intravenous administration of 5-aminolaevulinic acid-esters to mice bearing subcutaneous tumours produced lower porphyrin levels in the tumour than an equimolar dose of 5-aminolaevulinic acid. Reducing the dose of intravenous hexyl- or benzyl-ALA and topical hexyl-5-aminolaevulinic acid resulted in a dose-dependent reduction in porphyrin accumulation. A number of normal tissues accumulated higher concentrations of porphyrins than tumour tissue following intravenous administration of 5-aminolaevulinic acid-esters. Esterase activity in these normal tissues was greater than that in tumour tissue. In contrast to the situation in vivo, all of the 5-aminolaevulinic acid-esters examined were at least as effective as 5-aminolaevulinic acid when applied to cloned CaNT cells in vitro, with the drug concentration required for maximum porphyrin accumulation varying with ester chain-length. Tumour cells growing in culture released esterase activity into the medium. These findings suggest that the efficacy of 5-aminolaevulinic esters may vary depending on the esterase activity of the target tissue, and suggest caution when interpreting the findings of in vitro studies using these and similar prodrugs