14 research outputs found
Theory of low frequency waves in a rotating stratified channel
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Meteorology, 1974.Bibliography: leaf 70.by John A. Vermersch, Jr.M.S
Hydrographic station data obtained in the vicinity of Georges Bank, May and August, 1976
Two extended cruises were made during May and August,
1976, to measure the regional hydrographic structure in
the vicinity of Georges Bank on the New England Continental
Shelf. A summary of the hydrographic observations made
during Cruise E2B76 on the R/V Eastward and leg 3 of
Cruise 13 on the R/V Oceanus are presented in graphic form.Prepared for the United States Geological Survey
under Contract No. 14-08-0001-15615 and for· the
National Science Foundation under Grant OCE-76-01813
(WHOI)
Granulovacuolar Degenerations Appear in Relation to Hippocampal Phosphorylated Tau Accumulation in Various Neurodegenerative Disorders
BACKGROUND: Granulovacuolar degeneration (GVD) is one of the pathological hallmarks of Alzheimer's disease (AD), and it is defined as electron-dense granules within double membrane-bound cytoplasmic vacuoles. Several lines of evidence have suggested that GVDs appear within hippocampal pyramidal neurons in AD when phosphorylated tau begins to aggregate into early-stage neurofibrillary tangles. The aim of this study is to investigate the association of GVDs with phosphorylated tau pathology to determine whether GVDs and phosphorylated tau coexist among different non-AD neurodegenerative disorders. METHODS: An autopsied series of 28 patients with a variety of neurodegenerative disorders and 9 control patients were evaluated. Standard histological stains along with immunohistochemistry using protein markers for GVD and confocal microscopy were utilized. RESULTS: The number of neurons with GVDs significantly increased with the level of phosphorylated tau accumulation in the hippocampal regions in non-AD neurodegenerative disorders. At the cellular level, diffuse staining for phosphorylated tau was detected in neurons with GVDs. CONCLUSIONS: Our data suggest that GVDs appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders, while the presence of phosphorylated tau in GVD-harbouring neurons in non-AD neurodegenerative disorders was indistinguishable from age-related accumulation of phosphorylated tau. Although GVDs in non-AD neurodegenerative disorders have not been studied thoroughly, our results suggest that they are not incidental findings, but rather they appear in relation to phosphorylated tau accumulation, further highlighting the role of GVD in the process of phosphorylated tau accumulation
New England Shelf/Slope Experiment : February to August, 1976 : data report : the moored array
The New England Shelf/Slope Experiment (NESS76) was
conducted from February to August in 1976 over the continental
margin south of the New England coast. The initial objective
of the experiment was to examine the kinematic and dynamic
coupling of the low frequency oceanic motions between the outer
New England shelf and the deeper slope/rise regions; and in
particular, to monitor simultaneously the current, temperature,
and bottom pressure fluctuations across the New England
continental margin. The field program contained several
components: (1) a six-month moored array to monitor current,
temperature, and bottom pressure; (2) two hydrographic cruises
conducted around the moored array; (3) a collection and
synthesis of the synoptic meteorological data; and (4)
detailed bathymetric surveys conducted around the deeper
moorings.
The two hydrographic cruises were conducted during May
11-21 and August 12-23 of 1976, and the initial results from
the cruises have been reported elsewhere by Limeburner,
Vermersch, and Beardsley (1978). Only the moored array and the
meteorological data will be presented here.Prepared for the National Science Foundation under Grants
OCE 76-01813, OCE 78-19513, OCE 76-2590 and OCE 76-02190
Nantucket shoals flux experiment (NSFE79) : part 2, moored array data report
The Nantucket Shoals Flux Experiment (NSFE79) was conducted across the
continental shelf and upper slope south of Nantucket from March, 1979 to
April , 1980 to measure the flow of shelf water from the Georges Bank/Gulf
of Maine region into the Middle Atlantic Bight. Conceived as a cooperative
field experiment involving the Northeast Fisheries Center (NMFS),
U.S. Geological Survey (Woods Hole), University of New Hampshire, and the
Woods Hole Oceanographic Institution, the experiment contained two principal
components, a moored array of current meter and bottom instrumentation
deployed at six locations across the shelf and upper slope spanning
a depth range from 46 m to 810 m, and a series of 27 hydrographic surveys
made along or near the moored array line during the experiment. A basic
description of the NSFE79 hydrographic data has been given in Part 1 by
Wright (1983). A description of the moored array components and the
basic moored array data sets is presented here in Part 2.The NEFC participation was
supported by the NMFS Marine Resources Monitoring, Assessment, and Prediction
(MARt-1AP) Program. The U.S. Bureau of Land Management (BLM) supported
the USGS field and analysis component under t~emoranda of Understanding
M550-MU6-79, M551-MU8- 24, M551-MU9-4, and M551-MU0-18. The
WHO! and UNH field programs were supported by the National Science Foundation
under Grants OCE 78-19513 and OCE 78-26229