14 research outputs found

    Theory of low frequency waves in a rotating stratified channel

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    Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Meteorology, 1974.Bibliography: leaf 70.by John A. Vermersch, Jr.M.S

    Hydrographic station data obtained in the vicinity of Georges Bank, May and August, 1976

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    Two extended cruises were made during May and August, 1976, to measure the regional hydrographic structure in the vicinity of Georges Bank on the New England Continental Shelf. A summary of the hydrographic observations made during Cruise E2B76 on the R/V Eastward and leg 3 of Cruise 13 on the R/V Oceanus are presented in graphic form.Prepared for the United States Geological Survey under Contract No. 14-08-0001-15615 and for· the National Science Foundation under Grant OCE-76-01813 (WHOI)

    Granulovacuolar Degenerations Appear in Relation to Hippocampal Phosphorylated Tau Accumulation in Various Neurodegenerative Disorders

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    BACKGROUND: Granulovacuolar degeneration (GVD) is one of the pathological hallmarks of Alzheimer's disease (AD), and it is defined as electron-dense granules within double membrane-bound cytoplasmic vacuoles. Several lines of evidence have suggested that GVDs appear within hippocampal pyramidal neurons in AD when phosphorylated tau begins to aggregate into early-stage neurofibrillary tangles. The aim of this study is to investigate the association of GVDs with phosphorylated tau pathology to determine whether GVDs and phosphorylated tau coexist among different non-AD neurodegenerative disorders. METHODS: An autopsied series of 28 patients with a variety of neurodegenerative disorders and 9 control patients were evaluated. Standard histological stains along with immunohistochemistry using protein markers for GVD and confocal microscopy were utilized. RESULTS: The number of neurons with GVDs significantly increased with the level of phosphorylated tau accumulation in the hippocampal regions in non-AD neurodegenerative disorders. At the cellular level, diffuse staining for phosphorylated tau was detected in neurons with GVDs. CONCLUSIONS: Our data suggest that GVDs appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders, while the presence of phosphorylated tau in GVD-harbouring neurons in non-AD neurodegenerative disorders was indistinguishable from age-related accumulation of phosphorylated tau. Although GVDs in non-AD neurodegenerative disorders have not been studied thoroughly, our results suggest that they are not incidental findings, but rather they appear in relation to phosphorylated tau accumulation, further highlighting the role of GVD in the process of phosphorylated tau accumulation

    New England Shelf/Slope Experiment : February to August, 1976 : data report : the moored array

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    The New England Shelf/Slope Experiment (NESS76) was conducted from February to August in 1976 over the continental margin south of the New England coast. The initial objective of the experiment was to examine the kinematic and dynamic coupling of the low frequency oceanic motions between the outer New England shelf and the deeper slope/rise regions; and in particular, to monitor simultaneously the current, temperature, and bottom pressure fluctuations across the New England continental margin. The field program contained several components: (1) a six-month moored array to monitor current, temperature, and bottom pressure; (2) two hydrographic cruises conducted around the moored array; (3) a collection and synthesis of the synoptic meteorological data; and (4) detailed bathymetric surveys conducted around the deeper moorings. The two hydrographic cruises were conducted during May 11-21 and August 12-23 of 1976, and the initial results from the cruises have been reported elsewhere by Limeburner, Vermersch, and Beardsley (1978). Only the moored array and the meteorological data will be presented here.Prepared for the National Science Foundation under Grants OCE 76-01813, OCE 78-19513, OCE 76-2590 and OCE 76-02190

    Nantucket shoals flux experiment (NSFE79) : part 2, moored array data report

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    The Nantucket Shoals Flux Experiment (NSFE79) was conducted across the continental shelf and upper slope south of Nantucket from March, 1979 to April , 1980 to measure the flow of shelf water from the Georges Bank/Gulf of Maine region into the Middle Atlantic Bight. Conceived as a cooperative field experiment involving the Northeast Fisheries Center (NMFS), U.S. Geological Survey (Woods Hole), University of New Hampshire, and the Woods Hole Oceanographic Institution, the experiment contained two principal components, a moored array of current meter and bottom instrumentation deployed at six locations across the shelf and upper slope spanning a depth range from 46 m to 810 m, and a series of 27 hydrographic surveys made along or near the moored array line during the experiment. A basic description of the NSFE79 hydrographic data has been given in Part 1 by Wright (1983). A description of the moored array components and the basic moored array data sets is presented here in Part 2.The NEFC participation was supported by the NMFS Marine Resources Monitoring, Assessment, and Prediction (MARt-1AP) Program. The U.S. Bureau of Land Management (BLM) supported the USGS field and analysis component under t~emoranda of Understanding M550-MU6-79, M551-MU8- 24, M551-MU9-4, and M551-MU0-18. The WHO! and UNH field programs were supported by the National Science Foundation under Grants OCE 78-19513 and OCE 78-26229
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