Electoral news sharing:A study of changes in news coverage and Facebook sharing behaviour during the 2018 Mexican elections

Patterns of news consumption are changing drastically. Citizens increasingly rely on social media such as Facebook to read and share political news. With the power of these platforms to expose citizens to political information, the implications for democracy are profound, making understanding what is shared during elections a priority on the research agenda. Nevertheless, to the best of our knowledge, no study has yet explicitly explored how elections transform news sharing behaviour on Facebook. This study begins to remedy this by (a) investigating changes in news coverage and news sharing behaviour on Facebook by comparing election and routine periods, and by (b) addressing the ‘news gap’ between preferences of journalists and news consumers on social media. Employing a novel data set of news articles (N = 83,054) in Mexico, findings show that during periods of heightened political activity, both the publication and dissemination of political news increases, the gap between the news choices of journalists and consumers narrows, and that news sharing resembles a zero-sum game, with increased political news sharing leading to a decrease in the sharing of other news

URLs can facilitate machine learning classification of news stories across languages and contexts

Comparative scholars studying political news content at scale face the challenge of addressing multiple languages. While many train individual supervised machine learning classifiers for each language, this is a costly and time-consuming process. We propose that instead of rely-ing on thematic labels generated by manual coding, researchers can use ‘distant’ labels created by cues in article URLs. Sections reflected in URLs (e.g., nytimes.com/politics/) can therefore help create training material for supervised machine learning classifiers. Using cues provided by news media organizations, such an approach allows for efficient political news identification at scale while facilitating imple-mentation across languages. Using a dataset of approximately 870,000 URLs of news-related content from four countries (Italy, Germany, Netherlands, and Poland), we test this method by providing a comparison to ‘classical’ supervised machine learning and a multilingual BERT model, across four news topics. Our results suggest that the use of URL section cues to distantly annotate texts provides a cheap and easy-to-implement way of classifying large volumes of news texts that can save researchers many valuable resources without having to sacrifice quality

Beyond deficiency:Potential benefits of increased intakesof vitamin K for bone and vascular health

Vitamin K is wellknown for its role in the synthesisof a number of blood coagulationfactors.During recent years vitaminK-dependent proteins werediscovered to be of vital importancefor bone and vascular health.Recommendations for dietary vitaminK intake have been made onthe basis of the hepatic requirementsfor the synthesis of bloodcoagulation factors.Accumulatingevidence suggests that the requirementsfor other functions thanblood coagulation may be higher.This paper is the result of a closedworkshop (Paris,November 2002)in which a number of Europeanvitamin K experts reviewed theavailable data and formulated theirstandpoint with respect to recommendeddietary vitamin K intakeand the use of vitamin K-containingsupplements

Gla Rich Protein (GRP) is associated to osteoarthritis being highly accumulated in the joint tissues and synovial fluid

info:eu-repo/semantics/publishedVersio

Identifiability of Biologicals in Adverse Drug Reaction Reports Received From European Clinical Practice

Biologicals are established treatment options that require pharmacovigilance adapted to their specific nature, including the need for products to be identifiable up to the specific manufacturer in reports of adverse drug reactions (ADRs). This study explored the identifiability of 10 classes of similar and related biologicals up to the level of the manufacturer in ADR reports received from European clinical practice between 2011 and June 2016. Adequate identifiers were reported for 96.7% of the suspected biologicals, ranging from 89.5% for filgrastim to 99.8% for interferon beta‐1a. The product identifiability remained consistently high over time for classes of biologicals for which biosimilars were introduced during follow‐up. The overall batch traceability was, however, only ensured for 20.5% of the suspected biologicals and needs further improvement. This study shows that the European system for identification of ADRs to the level of the manufacturer is robust, allowing for the timely detection of potential product‐specific safety signals for biologicals

R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases

R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at http://mips.helmholtz-muenchen.de/proj/rspider

Climate related sea-level variations over the past two millennia

Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of National Academy of Sciences for personal use, not for redistribution. The definitive version was published in Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 11017-11022, doi:10.1073/pnas.1015619108.We present new sea-level reconstructions for the past 2100 years based on salt-marsh sedimentary sequences from the US Atlantic coast. The data from North Carolina reveal four phases of persistent sea-level change after correction for glacial isostatic adjustment. Sea level was stable from at least BC 100 until AD 950. It then increased for 400 years at a rate of 0.6 mm/yr, followed by a further period of stable, or slightly falling, sea level that persisted until the late 19th century. Since then, sea level has risen at an average rate of 2.1 mm/yr, representing the steepest, century-scale increase of the past two millennia. This rate was initiated between AD 1865 and 1892. Using an extended semi-empirical modeling approach, we show that these sea-level changes are consistent with global temperature for at least the past millennium.Research was supported by NSF grants (EAR-0951686) to BPH and JPD. ACK thanks a NOSAMS internship, UPenn paleontology stipend and grants from GSA and NAMS. North Carolina sea-level research was funded by NOAA (NA05NOS4781182), USGS (02ERAG0044) and NSF (EAR-0717364) grants to BPH with S. Culver and R. Corbett (East Carolina University). JPD (EAR-0309129) and MEM (ATM-0542356) acknowledge NSF support. MV acknowledges Academy of Finland Project 123113 and COST Action ES0701

How to find and diagnose a CDG due to defective N-glycosylation

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Gel meloksikama za topičku primjenu: In vitro i in vivo vrednovanje

Skin delivery of NSAIDs offers several advantages over the oral route associated with potential side effects. In the present investigation, topical gel of meloxicam (MLX) was formulated using N-methyl pyrrolidone (NMP) as a solubilizer and Carbopol Ultrez 10® as a gelling polymer. MLX gel was evaluated with respect to different physicochemical parameters such as pH, viscosity and spreadability. Irritation potential of MLX gel was studied on rabbits. Permeation of MLX gel was studied using freshly excised rat skin as a membrane. Anti-inflammatory activity of MLX gel was studied in rats and compared with the commercial formulation of piroxicam (Pirox® gel, 0.5 %, m/m). Accelerated stability studies were carried out for MLX gel for 6 months according to ICH guidelines. MLX gel was devoid of any skin irritation in rabbits. After 12 h, cumulative permeation of MLX through excised rat skin was 3.0 ± 1.2 mg cm2 with the corresponding flux value of 0.24 ± 0.09 mg cm2 h1. MLX gel exhibited significantly higher anti-inflammatory activity in rats compared to Pirox® gel. Physicochemically stable and non-irritant MLX gel was formulated which could deliver significant amounts of active substance across the skin in vitro and in vivo to elicit the anti-inflammatory activity.Primjena nesteroidnih protuupalnih lijekova na kožu ima nekoliko prednosti nad peroralnim načinom primjene uz koju se vežu određene nuspojave. U radu je opisana priprava gela meloksikama (MLX) za topičku primjenu. U pripravi gela korišten je N-metil pirolidon (NMP) kao otapalo i Carbopol ultrez 10® kao polimer za geliranje. Određivani su različiti fizikokemijski parametri kao što su pH, viskoznost i razmazljivost. Potencijalna iritacija MLX gela testirana je na kunićima, a svojstvo permeacije na svježim izrescima kože štakora. Protuupalno djelovanje praćeno je na štakorima i uspoređeno s registriranim pripravkom piroksikama (Pirox® gel, 0,5 % m/m). Testovi ubrzanog starenja MLX gela rađeni su tijekom 6 mjeseci prema ICH protokolu. Dobiveni rezultati ukazuju da MLX gel nimalo ne iritira kožu kunića. Kumulativna permeacija nakon 12 h bila je 3,0 ± 1,2 mg cm2, s odgovarajućem vrijednošću fluksa 0,24 ± 0,09 mg cm2 h1. MLX gel pokazao je značajno jače protuupalno djelovanje u odnosu na Pirox® gel. Pripravljeni gel je stabilan, ne iritira kožu, te in vitro i in vivo doprema kroz kožu ljekovitu tvar u dovoljnoj količini da ispolji protuupalno djelovanje