Morphological characterization of the nasopalatine region in human fetuses and its association to pathologies

The nasopalatine region is composed of structures such as the vomeronasal organ and nasopalatine duct. The nasopalatine duct may provide the communication of the mouth to the nasal cavity in human fetuses and can be obliterated in an adult human. Knowledge on the development of the nasopalatine region and nasopalatine duct in humans is necessary for understanding the morphology and etiopathogenesis of lesions that occur in this region. Objective: The aim of the present study was to describe the morphological aspects of the nasopalatine region in human fetuses and correlate these aspects with the development of pathologies in this region. Material and Methods: Five human fetuses with no facial or palatine abnormalities were used for the acquisition of specimens from the nasopalatine region. After demineralization, the specimens were histologically processed. Histological cuts were stained with methylene blue to orient the cutting plane and hematoxylin-eosin for the descriptive histological analysis. Results: The age of the fetuses was 8.00, 8.25, 9.00 and 9.25 weeks, and it was not possible to determine the age in the last one. The incisive canal was observed in all specimens as an opening delimited laterally by the periosteum and connecting oral and nasal cavity. The nasopalatine duct is an epithelial structure with the greatest morphological variation, with either unilateral or bilateral occurrence and total patent, partial patent and islet forms. The vomeronasal organ is a bilateral epithelized structure located alongside the nasal septum above the incisive canal in all the fetuses. Conclusions: The incisive canal, nasopalatine duct and vomeronasal organ are distinct anatomic structures. The development of nasopalatine duct cysts may occur in all forms of the nasopalatine duct

Oral and Cutaneous Melanoma: Similarities and Differences

Melanomas are malignant lesions stemming from the disorganized proliferation of melanocytes. This condition is more common on skin, but may also be detected in mucosa, such as in the oral cavity. The aim of the present study was to report similarities and differences between oral and cutaneous melanoma

Extensive myiasis infestation over a squamous cell carcinoma in the face : case report

Human myiasis is a parasitosis found in tropical and underdeveloped countries. It usually affects the elderly, unhealthy and mentally disabled individuals. It is caused by dipterous that lay their eggs in necrotic or infected tissues, although areas of the body that are apparently healthy can also be affected. Frequently the fly deposits several eggs on the peripheral parts of scratches and wounds. The treatment of myiasis involves mechanical removal of the larvae with hemostatic pincers. Larvae rupture must be avoided. Application of topical ether or similar volatile substance is useful. Preventive approach measures, including basic health care, hygiene, access to primary health service, and safe water and drainage, are fundamental to prevent human myiasis. The authors present a case report of myiasis infestation over an extensive head and neck squamous cell carcinoma from a 72-year-old patient living in a rural area. Approximately 200 larvae were removed and the patient was taken to the hospital?s head and neck surgery service

Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds

Background. Fibroblasts on the edges of a surgical wound are induced to synthesize collagen during the healing process which is known as fibroplasia. Objective. The aim of this study was to determine the effect of the application of different substances on fibroplasia of cutaneous surgical wounds on rats. Materials and Methods. 48 Wistar rats were divided into three groups. A surgical wound 1 cm in diameter and 1  mm in depth was created on the dorsum of each animal. The surgical wounds were submitted to the topical application of an alcoholic extract of 30% propolis, 70% alcohol, or 0.001% dexamethasone in a cream base every 12 hours. The animals were sacrificed three, seven, 14, and 28 days postoperatively. The specimens were histologically processed and stained with Masson's trichrome. The assessment of fibroplasia was performed using a scoring system: (1) 5 to 25% collagen deposition; (2) 26 to 50% collagen deposition; (3) 51 to 75% collagen deposition; (4) more than 75% collagen deposition. Results. There were statistically significant differences in collagen deposition between the substances at all postoperative evaluation times. Conclusion. Propolis and alcohol promoted greater collagen deposition in surgical wounds than dexamethasone

The study of morphologic changes induced by urethane in an oral chemical carcinogenesis DMBA-induced model

A proposta deste trabalho resultou da necessidade de se avaliar o potencial carcinogênico da uretana, em concentragoes mais baixas, a partir do modelo experimental de carcinogenese bucal DMBA-induzida. Cem hamsters sírios dourados foram separados em cinco grupos experimentais. 0 grupo 1 recebeu aplicações topicas de uretana 0.5% na borda lateral da língua; grupo 2, uretana 6%; grupo 3 uretana 0.5% + DMBA; grupo 4, uretana 6% + DMBA, e o grupo 5 — DMBA (controle positivo). Os dados obtidos mostraram que a uretana a 0.5% e 6% não induziu alterações histolOgicas nos grupos 1 e 2. A formação de carcinomas nos animais tratados com uretana e DMBA ocorreu em proporções menores quando comparada com o grupo controle positivo (DMBA). A uretana a 0.5% e 6% reduziu a carcinogenicidade do DMBA, e não apresentou potencial carcinogenic° de iniciação, promoção e/ou progressão.The study examined the carcinogenic potential of urethane in lower concent:ration forms according to the experimental oral carcinogenese DMBA-induced model. One hundred Syrian golden hamsters were separated in five experimental groups. Group 1 receivecl 0.5% urethane topical applications along in the lateral border of the tongue; group 2, 6% urethane; group 3, 0.5% urethane + 9,10 dimethyl 1,2-benzantracene (DMBA); group 4, 6% urethane + DMBA; and group 5, assigned positive control, DMBA. The results indicated no histological alterations in groups 1 anel 2 inducecl by 0.5% and 6% urethane. The formation of carcinomas in animals treated with urethane and DMBA wa:s visible in lesser proportions when compareci with the positive control group (DMBA). The 0.5% and 6% urethane decreased carcinogenicity of DMBA and did not present carcinogenic potential for initiation, promotion and/or its progression

Angiog?nese de ferida cir?rgica em l?ngua de rato : an?lise por meio de microscopia eletr?nica de varredura de modelo vascular

Made available in DSpace on 2015-04-14T13:30:43Z (GMT). No. of bitstreams: 1 379483.pdf: 11148782 bytes, checksum: 3e2c17b0713861a21e02b80c5cd06cd8 (MD5) Previous issue date: 2006-05-30A t?cnica de moldagem vascular seguida de corros?o, associada ? microscopia eletr?nica de varredura (MEV), ? um m?todo adequado para descrever a angioarquitetura de diferentes ?rg?os e para verificar a ocorr?ncia de angiog?nese por intussuscep??o e por brotamento. O l?men dos vasos ? moldado com resina e a corros?o do tecido circunjacente ? resina com solu??o alcalina. O objetivo do presente estudo foi descrever o padr?o vascular do ventre da l?ngua de ratos Wistar submetidos ou n?o a uma ferida na regi?o, verificar a ocorr?ncia de angiog?nese por brotamento e por intussuscep??o durante a cicatriza??o em diferentes tempos p?s-operat?rios. No ventre da l?ngua dos animais n?o submetidos ao procedimento cir?rgico, foi observada a presen?a de trama vascular superficial em forma de rede frouxa, e de varia??es anat?micas dos vasos confluentes das veias raninas. Nos ratos submetidos ao procedimento cir?rgico, no primeiro dia p?s-operat?rio, as extremidades dos capilares venosos seccionados apresentaram forma c?nica, e dos capilares arteriais, forma arredondada. No segundo dia p?s-operat?rio, iniciou-se o processo de angiog?nese por intussuscep??o e por brotamento. No terceiro dia p?s-operat?rio, observou-se tamb?m a ocorr?ncia destas angiog?nese nos capilares do tecido de granula??o. No s?timo dia p?s-operat?rio, todo o leito cir?rgico encontrava-se revascularizado com capilares centrais paralelos entre si e perpendiculares ? trama vascular superficial circunjacente. No 14o dia p?s-operat?rio, os capilares centrais apresentaram inclina??o gradual que, no 21o dia, juntamente com a trama vascular superficial, formaram o padr?o radial a partir do centro da ferida. O padr?o vascular da superf?cie ventral da l?ngua, 21 dias ap?s o procedimento cir?rgico, ainda n?o se encontra na mesma organiza??o e disposi??o do padr?o vascular das l?nguas n?o submetidas ao procedimento cir?rgico. A ocorr?ncia de angiog?nese por intussuscep??o e por brotamento ? mais freq?ente no limite posterior da ferida cir?rgica e no segundo e no terceiro dia p?s-operat?rio

Basosquamous carcinoma: Histopathological features

Basosquamous carcinoma (BSC) is a rare aggressive epithelial neoplasm with features of both basal cell carcinoma and squamous cell carcinoma, with a tendency toward local recurrence and a propensity for lymph node and distant metastases. The aim of the present study was to report the case of a 63-year-old Caucasian male with BSC in the auricular region

Dor, ansiedade e qualidade de vida relacionada à saúde bucal de pacientes atendidos no serviço de urgência odontológica

Resumo O objetivo deste estudo foi avaliar associação entre dor pré-operatória, ansiedade e impacto da condição bucal na qualidade de vida dos pacientes atendidos no serviço de Urgência Odontológica da Universidade Federal dos Vales do Jequitinhonha e Mucuri. Estudo transversal retrospectivo foi conduzido avaliando dados clínicos de 240 prontuários de pacientes com idades entre 18 e 65 anos. A dor foi mensurada pela Heft-Parker Visual Analogue Scale; ansiedade, pela Corah’s Detal Anxiety Scale e qualidade de vida, pelo Oral Health Impact Profile (OHIP-14). Associações foram analisadas pelo Teste qui-quadrado de Pearson (p < 0,05). Foi observada associação estatisticamente significante entre dor e pior qualidade de vida, com impacto nos domínios desconforto psicológico (p < 0,001), incapacidade física (p < 0,001), psicológica (p < 0,001) e social (p < 0,001). Ansiedade influenciou na pior qualidade de vida, com impacto nos domínios desconforto psicológico (p = 0,009), incapacidade fisica (p = 0,016), psicológica (p = 0,011) e desvantagem social (p = 0,028). Esse estudo é relevante para o planejamento de ações voltadas para a saúde bucal dos pacientes atendidos nos serviços de urgência odontológica, priorizando aqueles com maiores impactos psicossociais decorrentes dos problemas bucais