Kappia lobulata (Apocynaceae, Periplocoideae), a new genus from South Africa

Kappia, a new genus from the Fish River Valley in the Eastern Cape Province, South Africa is presented. At first described as Raphionacme lobulata Venter and R.L.Verh. [Venter, H.J.T., Verhoeven, R.L. 1988. Raphionacme lobulata (Periplocaceae), a new species from the eastern Cape Province, South Africa. South African Journal of Botany 54, 603–606.] based on a single specimen collected in 1936, recently discovered plants of this species proved it to be a new genus. In habit Kappia resembles Baseonema Schltr. and Rendle, Batesanthus N.E.Br., Mondia Skeels and Stomatostemma N.E.Br. However, as far as floral structure is concerned, Kappia reveals more affinity with Raphionacme Harv. DNA sequence data show Kappia to be distinct from Batesanthus, Mondia and Raphionacme Harv. and weakly supported as a sister to Stomatostemma

An electron channeling study of polycrystalline YBa2Cu3Ox

An electron channeling study has been done on large grained YBa2Cu3Ox samples. Selected area channeling patterns (SACP) were used to examine several dozen grains on electropolished surfaces and it was demonstrated that (a) the twin planes observed in polarized optical light microscopy lie parallel to {110} crystal planes, and (b) the long flat sides of high aspect ratio grains are formed by basal planes, and the shorter sides are formed by either (010), (100), or {110} planes. A majority of the large grains examined were found to contain subgrains, misaligned by 0.5°–1° and ranging in size from less than 3 to 20 μm. The origin of the subgrains is not understood

Device Design Modifications Informed by In Vitro Testing of Bacterial Attachment Reduce Infection Rates of Cochlear Implants in Clinical Practice.

Recalcitrant chronic infections of implanted medical devices are often linked to the presence of biofilms. The prevention and treatment of medical device-associated infections is a major source of antibiotic use and driver of antimicrobial resistance globally. Lowering the incidence of infection in patients that receive implanted medical devices could therefore significantly improve antibiotic stewardship and reduce patient morbidity. Here we determined if modifying the design of an implantable medical device to reduce bacterial attachment, impacted the incidence of device-associated infections in clinical practice. Since the 1980s cochlear implants have provided long-term treatment of sensorineural hearing deficiency in hundreds of thousands of patients world-wide. Nonetheless, a relatively small number of devices are surgically explanted each year due to unresolvable infections. Features associated with the accumulation of bacteria on the Cochlear™ Nucleus® CI24RE™ model of cochlear implant devices were identified using both in vitro bacterial attachment assays and examination of explanted devices. Macro-scale design modifications that reduced bacterial attachment in vitro were incorporated into the design of the CI500™ and Profile™ series of Nucleus implant. Analyses of mandatory post-market vigilance data of 198,757 CI24RE and 123,084 CI500/Profile series implantation surgeries revealed that these design modifications correlated with significantly reduced infection rates. This study demonstrates that a design-centric approach aimed at mitigating bacterial attachment was a simple, and effective means of reducing infections associated with Cochlear Nucleus devices. This approach is likely to be applicable to improving the designs of other implantable medical devices to reduce device-associated infections

Androgens and spermatogenesis: lessons from transgenic mouse models

Transgenic mouse models have contributed considerably to our understanding of the cellular and molecular mechanisms by which androgens control spermatogenesis. Cell-selective ablation of the androgen receptor (AR) in Sertoli cells (SC) results in a complete block in meiosis and unambiguously identifies the SC as the main cellular mediator of the effects of androgens on spermatogenesis. This conclusion is corroborated by similar knockouts in other potential testicular target cells. Mutations resulting in diminished expression of the AR or in alleles with increased length of the CAG repeat mimick specific human forms of disturbed fertility that are not accompanied by defects in male sexual development. Transcriptional profiling studies in mice with cell-selective and general knockouts of the AR, searching for androgen-regulated genes relevant to the control of spermatogenesis, have identified many candidate target genes. However, with the exception of Rhox5, the identified subsets of genes show little overlap. Genes related to tubular restructuring, cell junction dynamics, the cytoskeleton, solute transportation and vitamin A metabolism are prominently present. Further research will be needed to decide which of these genes are physiologically relevant and to identify genes that can be used as diagnostic tools or targets to modulate the effects of androgens in spermatogenesis

Interaction of river hydraulics and vegetation dynamics

The universities of Ghent and Antwerp are investigating the impact of the vegetation on hydraulic characteristics of the river Aa (Antwerp, Belgium) and the Bierbza river (Poland). In these areas the interaction between groundwater, surface water and vegetation will be studied.In a first phase of this multidisciplinary study, the influence of the vegetation on the flow resistance in the stretch is examinated. Introducing the effective roughness of the bottom and the banks of the river into hydraulic computations is not that easy, but important. Different expressions for the roughness coefficient are available, each with their own restrictions. Certainly when plants occur in the channel and reduce the flow area, determination of the roughness coefficient is difficult. Simultaneousley, flood forecasting and other impacts of changing water levels and flows, ask for an accurate hydraulic model. Modelling summer situations with winter data and vice versa imply problems.The roughness coefficient of the river, as used in the Manning formula, is influenced by the vegetation. Further more, the Manning coefficient is also linked to the water velocity and the discharge. The kind of correlation is determined by the vegetation type.Field measurements are carried out to collect data on discharge and stage and on the amount and variation of aquatic weed growth. Velocity measurements in multiple cross sections are performed with both, a hydrometric propeller and an electromagnetic device. Further more, leakage or seepage from the groundwater influences the water balance and has to be included. Several measurement campaigns on both rivers allow to determine the variation of the friction factor (Manning n) as a function of time, vegetation and distance and the important hydraulic parameters, and all the information can be related to each other.Following a seasonal cycle, flow resistance increases with plant growth in spring, reaches a maximum in early summer and then decreases slowly to the minimum in winter. Knowledge of the variation of the biomass as a function of time should lead to appropriate use of roughness coefficients in modelling surface flow in rivers

Flood routing in the river Aa using ’Femme’

The software ’Femme’, (a flexible environment for mathematically modelling the environment) is developed by the Netherlands Institute of Ecology (NIOO)(Soetaert et al., 2004) and is used for the modelling of ecological processes. Femme’s code is open source and works on a modular base. The implementation of a one dimensional hydrodynamic model into ’Femme’ to study the interaction between ecological processes and surface water flow as a driving force and the validation using field measurements is subject of this research. For example, the presence of macrophytes has an influence on the discharge by way of the entire roughness of the river, expressed by the Manning coefficient.River hydraulics is characterised by changing discharges and water levels due to rain fall, so studies have to take into account the non-permanent character of the flow. In a first phase, the river characteristics and the simplified Saint-Venant equations have been built into the model. The simplification to the parabolic and the kinematic equations allow a faster and easier solution. The parabolic model is known as the convection-diffusion equation and describes the translation, deformation and attenuation of a wave in open channels and is valid for stretches with mild slopes. The kinematic model doesn’t take into account the flattening of the wave and can only be applied in short stretches.Calculation results are presented by the variation of the discharge as a function of distance. Also the influence of the roughness coefficient is shown.The integrated study of ecological processes and surface water flow is situated in a multidisciplinary research were attention is paid to the interaction of groundwater, surface water and the ecological system in order to describe the transport of matter through river basins (Buis et al.,2005). An important study area is the river Aa near Poederlee (Belgium, Flanders, province of Antwerp), were discharge, grondwater and biomass measurements are carried out on a regular base, to perform studies in the field and to collect calibration data for the integrated hydraulics and ecology model

Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice

<b>Background</b>: Testicular microliths are calcifications found within the seminiferous tubules. In humans, testicular microlithiasis (TM) has an unknown etiology but may be significantly associated with testicular germ cell tumors. Factors inducing microlith development may also, therefore, act as susceptibility factors for malignant testicular conditions. Studies to identify the mechanisms of microlith development have been hampered by the lack of suitable animal models for TM.<BR/> <b>Methods</b>: This was an observational study of the testicular phenotype of different mouse models. The mouse models were: cryptorchid mice, mice lacking androgen receptors (ARs) on the Sertoli cells (SCARKO), mice with a ubiquitous loss of androgen ARs (ARKO), hypogonadal (hpg) mice which lack circulating gonadotrophins, and hpg mice crossed with SCARKO (hpg.SCARKO) and ARKO (hpg.ARKO) mice.<BR/> <b>Results</b>: Microscopic TM was seen in 94% of hpg.ARKO mice (n=16) and the mean number of microliths per testis was 81 +/- 54. Occasional small microliths were seen in 36% (n=11) of hpg testes (mean 2 +/- 0.5 per testis) and 30% (n=10) of hpg.SCARKO testes (mean 8 +/- 6 per testis). No microliths were seen in cryptorchid, ARKO or SCARKO mice. There was no significant effect of FSH or androgen on TM in hpg.ARKO mice.<BR/> <b>Conclusions</b>: We have identified a mouse model of TM and show that lack of endocrine stimulation is a cause of TM. Importantly, this model will provide a means with which to identify the mechanisms of TM development and the underlying changes in protein and gene expression

(In)Complete acquisition of Turkish among Turkish German bilinguals in Germany and Turkey: an analysis of complex embeddings in narratives

Although most researchers recognise that the language repertoire of bilinguals can mvary, few studies have tried to address variation in bilingual competence in any detail. This study aims to take a first step towards further understanding the way in which bilingual competencies can vary at the level of syntax by comparing the use of syntactic embeddings among three different groups of Turkish/German bilinguals. The approach of the present paper is new in that different groups of bilinguals are compared with each other, and not only with monolingual speakers, as is common in most studies in the field. The analysis focuses on differences in the use of embeddings in Turkish, which are generally considered to be one of the more complex aspects of Turkish grammar. The study shows that young Turkish/German bilingual adults who were born and raised in Germany use fewer, and less complex embeddings than Turkish/German bilingual returnees who had lived in Turkey for eight years at the time of recording. The present study provides new insights in the nature of bilingual competence, as well as a new perspective on syntactic change in immigrant Turkish as spoken in Europe