D2.1 User requirements and needs and gaps analysis report

This report has been submitted by Fondazione Scuola di Pace di Monte Sole (Italy) as deliverable D2.1 within the framework of H2020 project "SO-CLOSE: Enhancing Social Cohesion through Sharing the Cultural Heritage of Forced Migrations" Grant No. 870939.This report illustrates the main findings of the SO-CLOSE WP2 collective research, based on participatory methods and group reflections (co-creation and focus groups).The idea is to enlighten coherences and resources as well as questionable and problematic points, in order to help WP3, WP4 and WP5 with new and tested ideas together with suggestions to mitigate possible obstacles, misunderstandings and mistakes. The text starts illustrating a short analytical premise and it then covers the 4 main SO-CLOSE fields of interest: historical memory, social cohesion, cultural heritage and methods and tools for sharing between native and refugee/asylum seekers communities

Brightest Cluster Galaxies in the Extended GMRT radio halo cluster sample. Radio properties and cluster dynamics

Brightest Cluster Galaxies (BCGs) show exceptional properties over the whole electromagnetic spectrum. Their special location at the centres of galaxy clusters raises the question of the role of the environment on their radio properties. To decouple the effect of the galaxy mass and of the environment in their statistical radio properties, we investigate the possible dependence of the occurrence of radio loudness and of the fractional radio luminosity function on the dynamical state of the hosting cluster. We studied the radio properties of the BCGs in the Extended GMRT Radio Halo Survey (EGRHS). We obtained a statistical sample of 59 BCGs, which was divided into two classes, depending on the dynamical state of the host cluster, i.e. merging (M) and relaxed (R). Among the 59 BCGs, 28 are radio-loud, and 31 are radio--quiet. The radio-loud sources are located favourably located in relaxed clusters (71\%), while the reverse is true for the radio-quiet BCGs, mostly located in merging systems (81\%). The fractional radio luminosity function (RLF) for the BCGs is considerably higher for BCGs in relaxed clusters, where the total fraction of radio loudness reaches almost 90\%, to be compared to the $\sim$30\% in merging clusters. For relaxed clusters, we found a positive correlation between the radio power of the BCGs and the strength of the cool core, consistent with previous studies on local samples. Our study suggests that the radio loudness of the BCGs strongly depends on the cluster dynamics, their fraction being considerably higher in relaxed clusters. We compared our results with similar investigations, and briefly discussed them in the framework of AGN feedback.Comment: 12 pages, 6 figures, 3 tables, A&A accepte

Il quartiere stazione di Pisa fra trasformazione e conflitto

The city of Pisa (Italy) has experienced in the last decade a high level of migration from countries of Northern and Central Africa, Eastern Europe and China. As often happens , the migrants of different ethnic groups are located in the neighborhood around the train station, both as regards the commercial activities and the housing. In addition, several areas of the district are used by migrants as a meeting place. From the point of view of the urban landscape, the district has experienced considerable demographic and visual transformations, which are an indication of conflict and the level of integration of migrants among themselves and with Italians residents. This article aims to show, in a diachronic perspective, the changes in the urban landscape occurred in the neighborhood and the elements of conflict that results, among other elements, from the analysisof the ordinances of the police recently posted in the district.

Il quartiere stazione di Pisa fra trasformazione e conflitto

Abstract – The city of Pisa (Italy) has experienced in the last decade a high level of migration from countries of Northern and Central Africa, Eastern Europe and China. As often happens, the migrants of different ethnic groups are located in the neighborhood around the train station, both as regards the commercial activities and the housing. In addition, several areas of the district are used by migrants as a meeting place. From the point of view of the urban landscape, the district has experienced considerable demographic and visual transformations, which are an indication of conflict and the level of integration of migrants among themselves and with Italians residents. This article aims to show, in a diachronic perspective, the changes in the urban landscape occurred in the neighborhood and the elements of conflict that results, among other elements, from the analysis of the ordinances of the police recently posted in the district

Infantile cortical hyperostosis and COL1A1 mutation in four generations

Infantile cortical hyperostosis (ICH, OMIM 114000) is a rare familial disorder which affects infants. It spontaneously heals in the first years of life. The disease is characterized by regressive subperiosteal hyperosteogenesis mainly affecting long bones, mandible, clavicles, and ribs which are remarkably swollen and deformed on X-rays. But it is also important to take into consideration the autosomal dominant pattern of inheritance to detect it. In 2005 Gensure et al. detected 3040C→T mutation in COL1A1 gene in three unrelated ICH families. Four generations of patients belonging to the same family were examined in our study. Molecular testing has now disclosed a pathogenic mutation in nine of them. The patients spontaneously recovered. Although our paper shows a distinct correlation between R836C mutation and ICH, there is a certain interindividual and intra-familial variability

Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy

Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments. We verified whether this pattern is influenced by an abnormal glucose tolerance (AGT). In 10 patients with DCM, 5 with normal glucose tolerance (DCM-NGT) and 5 with AGT (DCM-AGT), and 5 non-DCM subjects with AGT (N-AGT), we measured coronary blood flow and arteriovenous differences of oxygen and metabolites during Rest, Pacing (at 130 b/min), and Recovery. Myocardial lactate exchange and oleate oxidation were also measured. At Rest, DCM patients showed a reduced nonesterified fatty acids (NEFA) myocardial uptake, while glucose utilization increased only in DCM-AGT. In response to Pacing, glucose uptake promptly rose in N-AGT (from 72 ± 21 to 234 ± 73 nmol/min/g, p<0.05), did not change in DCM-AGT, and slowly increased in DCM-NGT. DCM-AGT sustained the extra workload by increasing NEFA oxidation (from 1.3 ± 0.2 to 2.9 ± 0.1 mol/min/gO2 equivalents, p<0.05), while DCM-NGT showed a delayed increase in glucose uptake. Substrate oxidation rates paralleled the metabolites data. The presence of AGT in patients with DCM exacerbates both the shift from fat to carbohydrates in resting myocardial metabolism and the reduced myocardial metabolic flexibility in response to an increased workload. This trial is registered with ClinicalTrial.gov NCT02440217

Health Through a Human Right Lens at the US-Mexico Border: Increasing Access to Healthcare for Central American Immigrants

The number of immigrants seeking entry into the U.S. through asylum requests or through irregular means is increasing, and most come from the Northern Triangle of El Salvador, Guatemala, and Honduras. Immigrants come fleeing extreme poverty, violence, health and social inequities, and drastic climate changes. Most had limited access to healthcare at home, and even more limited care along the journey. Those that are allowed entry into the U.S., are confronted with feeling unwelcome in many communities, having to navigate an array of local, state, and federal laws that regulate access to healthcare. We need immigration policies that preserve the health, dignity with a multinational policy for provision of healthcare through a human rights lens from point of origin to point of destination

West Nile virus transmission. results from the integrated surveillance system in Italy, 2008 to 2015

IIn Italy a national Plan for the surveillance of imported and autochthonous human vector-borne diseases (chikungunya, dengue, Zika virus disease and West Nile virus (WNV) disease) that integrates human and veterinary (animals and vectors) surveillance, is issued and revised annually according with the observed epidemiological changes. Here we describe results of the WNV integrated veterinary and human surveillance systems in Italy from 2008 to 2015. A real time data exchange protocol is in place between the surveillance systems to rapidly identify occurrence of human and animal cases and to define and update the map of affected areas i.e. provinces during the vector activity period from June to October. WNV continues to cause severe illnesses in Italy during every transmission season, albeit cases are sporadic and the epidemiology varies by virus lineage and geographic area. The integration of surveillance activities and a multidisciplinary approach made it possible and have been fundamental in supporting implementation of and/or strengthening preventive measures aimed at reducing the risk of transmission of WNV trough blood, tissues and organ donation and to implementing further measures for vector control

Current and emerging treatments for the management of osteogenesis imperfecta

Osteogenesis imperfecta (OI) is the most common bone genetic disorder and it ischaracterized by bone brittleness and various degrees of growth disorder. Clinical severityvaries widely; nowadays eight types are distinguished and two new forms have been recentlydescribed although not yet classified. The approach to such a variable and heterogeneousdisease should be global and therefore multidisciplinary. For simplicity, the objectives oftreatment can be reduced to three typical situations: the lethal perinatal form (type II), inwhich the problem is survival at birth; the severe and moderate forms (types III–IX), in whichthe objective is ‘autonomy’; and the mild form (type I), in which the aim is to reach ‘normallife’. Three types of treatment are available: non-surgical management (physical therapy,rehabilitation, bracing and splinting), surgical management (intramedullary rod positioning,spinal and basilar impression surgery) and medical-pharmacological management (drugs toincrease the strength of bone and decrease the number of fractures as bisphosphonates or growthhormone, depending on the type of OI). Suggestions and guidelines for a therapeutic approachare indicated and updated with the most recent findings in OI diagnosis and treatment

Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes:The SUMMIT VIP Study

Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms to identify clinically useful markers of risk for cardiovascular (CV) events in subjects with type 2 diabetes (T2D) with or without manifest CVD