Estimation of annual risk of tuberculosis infection among children irrespective of BCG scar in the south zone of India

Objective: To estimate the proportion infected and compute Annual Risk of Tuberculosis Infection (ARTI) among children irrespective of BCG scar and compare with that among children without BCG scar. Methodology: Tuberculin survey was conducted in south zone of India as a part of the nation-wide survey to estimate the ARTI in different parts of the country and ARTI was computed among children without BCG scar excluding children with BCG scar. In this exercise, the tuberculin test results of children with BCG scar and irrespective of BCG scar were considered for analysis and the results were compared. Results: The prevalence of infection and ARTI estimated among children irrespective of BCG scar aged 1-9 years were 5.7% and 1.0% (95% C.I: 0.8-1.3) respectively. The corresponding figures among unvaccinated children were 5.9% and 1.0% (95% C.I: 0.7-1.4) respectively. The ARTI among children irrespective of BCG scar were similar to that among unvaccinated children. Conclusion: Estimation of proportion of children infected and computation of ARTI using mirror-image technique could be undertaken among children irrespective of BCG scar among children aged either from 1-9 years or 5-9 years

Annual Risk of Tuberculosis infection in Chennai City

Aim: To study the proportion of children infected with Mycobacterium Tuberculosis in Chennai city. Methodology: A cluster sampling methodology was adopted to select an estimated sample size of 7000 children from five corporation zones selected systematically from ten zones of the city. A total of 7098 children aged 1-9 years were subjected to Mantoux and test read; 1897 (27%) from slum area and 5201 (73%) from non-slum area. Results: The prevalence of infection among children without BCG scar was estimated to be 10.5 % (ARTI of 2.0%) and was similar to that among children irrespective of scar status. The prevalence of infection was higher among children in slum areas (11.1%; ARTI 2.1%) compared to non-slum areas (8.9%; ARTI 1.7%); but the difference was not statistically different. Conclusion: The tuberculosis situation in Chennai as measured by risk of infection was higher in urban city area than rural areas and comparable to that found in other cities as reported from earlier studies. This information can be used as baseline information for monitoring the epidemiological trends in Chennai city in future

Day-to-day variability of equatorial electrojet and its role on the day-to-day characteristics of the equatorial ionization anomaly over the Indian and Brazilian sectors

The equatorial electrojet (EEJ) is a narrow band of current flowing eastward at the ionospheric E region altitudes along the dayside dip equator. Mutually perpendicular electric and magnetic fields over the equator results in the formation of equatorial ionization anomaly (EIA), which in turn generates large electron density variabilities. Simultaneous study on the characteristics of EEJ and EIA is necessary to understand the role of EEJ on the EIA variabilities. This is helpful for the improved estimation of total electron content (TEC) and range delays required for satellite-based communication and navigation applications. Present study reports simultaneous variations of EEJ and GPS-TEC over Indian and Brazilian sectors to understand the role of EEJ on the day-to-day characteristics of the EIA. Magnetometer measurements during the low solar activity year 2004 are used to derive the EEJ values over the two different sectors. The characteristics of EIA are studied using two different chains of GPS receivers along the common meridian of 77E (India) and 45W (Brazil). The diurnal, seasonal, and day-to-day variations of EEJ and TEC are described simultaneously. Variations of EIA during different seasons are presented along with the variations of the EEJ in the two hemispheres. The role of EEJ variations on the characteristic features of the EIA such as the strength and temporal extent of the EIA crest has also been reported. Further, the time delay between the occurrences of the day maximum EEJ and the well-developed EIA is studied and corresponding results are presented in this paper.Facultad de Ciencias Astronómicas y Geofísica

Antigen receptor repertoires of one of the smallest known vertebrates

The rules underlying the structure of antigen receptor repertoires are not yet fully defined, despite their enormous importance for the understanding of adaptive immunity. With current technology, the large antigen receptor repertoires of mice and humans cannot be comprehensively studied. To circumvent the problems associated with incomplete sampling, we have studied the immunogenetic features of one of the smallest known vertebrates, the cyprinid fish Paedocypris sp. “Singkep” (“minifish”). Despite its small size, minifish has the key genetic facilities characterizing the principal vertebrate lymphocyte lineages. As described for mammals, the frequency distributions of immunoglobulin and T cell receptor clonotypes exhibit the features of fractal systems, demonstrating that self-similarity is a fundamental property of antigen receptor repertoires of vertebrates, irrespective of body size. Hence, minifish achieve immunocompetence via a few thousand lymphocytes organized in robust scale-free networks, thereby ensuring immune reactivity even when cells are lost or clone sizes fluctuate during immune responses

The subconvexity problem for \GL_{2}

Generalizing and unifying prior results, we solve the subconvexity problem for the $L$-functions of \GL_{1} and \GL_{2} automorphic representations over a fixed number field, uniformly in all aspects. A novel feature of the present method is the softness of our arguments; this is largely due to a consistent use of canonically normalized period relations, such as those supplied by the work of Waldspurger and Ichino--Ikeda.Comment: Almost final version to appear in Publ. Math IHES. References updated

Parametric analysis of Asymmetric Spur Gear Tooth

Abstract Gear is a machine element used to transmit motion and power between rotating shafts by means of progressive engagement of projections called teeth. Gears are classified according to the relative position of the axes of the shaft, type of gearing, peripheral velocity of the gears and position of teeth on gear surface. Presently gears are suffered by backlash the amount by which the width of a tooth space exceeds the thickness of the engaging tooth on the pitch circles, undercut a condition in generated gear teeth when any part of the fillet curve lies inside of a line drawn tangent to the working profile at its lowest point and interference is an important aspect of kinematics of gearing. When the gear tooth tries to dig below the base circle of mating gear then the gear tooth action shall be non conjugate and violate the fundamental law of gearing this non conjugate action is called the interference . These defects can be eliminated by increasing the pressure angle, by increasing the addendum of mating gear and another way of increasing the load capacity of transmissions is to modify the involute geometry. This has been a standard practice in sophisticated gear design for many years. The nomenclature describing these types of gear modifications can be quite confusing with reference to addendum modification or profile shift. An additional alteration that is very rarely used is to make the gears asymmetric with different pressure angles for each side of the tooth. An asymmetric spur gear drive means that larger and smaller pressure angles are applied for the driving and coast sides. The two profiles of a gear tooth are functionally different for most gear drives. The workload on one side of profile is significantly higher than the other Gears. The main objective of this paper is to generate asymmetric spur gear tooth geometry for different pressure angles on drive and coast side using computer programme. Developed programme is used to create a finite element model of gear tooth to study the effect of bending stress at the critical section for different pressure angles, different number of teeth and module. To study the effect of above asymmetric spur tooth parameters Finite Element Analysis software ANSYS was used

A study on wear failure analysis of tungsten carbide hardfacing on carbon steel blade in a digester tank

This paper addresses wear failure analysis of tungsten carbide (WC) hardfacing on a carbon steel blade known as the continuous digester blade (CD blade). The CD blade was placed in a digester tank to mix ilmenite ore with sulphuric acid as part of a production process. Tungsten carbide hardfacing was applied on the CD blade to improve its wear resistance while the CD blade was exposed to an abrasive and acidic environment. Failure analysis was car-ried out on the hardfaced CD blade in order to improve its wear resistance and lifetime. A thickness and hardness comparison study was conducted on worn and unworn specimens from the CD blades. The carbide distribution along with elemental composition analysis of the hardfaced CD blade specimens was examined using scanning electron microscopy and energy-dispersive spectroscopy. The investigation revealed that an inconsistent hardfacing thickness was welded around the CD blade. Minimum coating thickness was found at the edges of the blade surfaces causing failure to the blades as the bare carbon steel blades were exposed to the mixed environment. The wear resistance of the CD blade can be improved by distributing the carbide uniformly on the hardfaced coating. Applying extra coating coverage at the critical edge will prevent the exposure of bare carbon steel blade, thus increasing the CD blade lifetime

Using Relational Verification for Program Slicing

Program slicing is the process of removing statements from a program such that defined aspects of its behavior are retained. For producing precise slices, i.e., slices that are minimal in size, the program\u27s semantics must be considered. Existing approaches that go beyond a syntactical analysis and do take the semantics into account are not fully automatic and require auxiliary specifications from the user. In this paper, we adapt relational verification to check whether a slice candidate obtained by removing some instructions from a program is indeed a valid slice. Based on this, we propose a framework for precise and automatic program slicing. As part of this framework, we present three strategies for the generation of slice candidates, and we show how dynamic slicing approaches - that interweave generating and checking slice candidates - can be used for this purpose. The framework can easily be extended with other strategies for generating slice candidates. We discuss the strengths and weaknesses of slicing approaches that use our framework