Il suffisso -zione/-ción in italiano ed in spagnolo: analisi e trattamento dei dati per inclusione nel DIES/DEIS (Diccionario italiano-español de sufijos/Diccionario español-italiano de sufijos)

Este trabajo representa una propuesta para el análisis y el tratamiento del sufijo –zione/–ción en italiano y español y su inclusión en el diccionario de sufijos italiano-español/español-italiano (DIES/DEIS). Partiendo de un estudio pormenorizado de los ejemplos existentes de palabras en –zione/–ción proponemos un modelo de ficha de diccionario que recoja información lingüística en ambas lenguas y sea capaz de proporcionarla de forma clara tanto en soporte electrónico como en soporte papel.This work is a proposal for analysis and treatment of the suffix –zione/–ción in Italian and Spanish and its inclusion in the Italian- Spanish/Spanish Italian suffix dictionary (DIES/DEIS). Having carried out a comprehensive analysis of existing examples of words in –zione/–ción, we intend to propose a model of suffix dictionary card that contains clear linguistic information in both languages and in electronic and paper format

Explaining the anti-pageant petition

I would respectfully like to respond to Ms. Jane K. Bailey and her remarks on the petition being circulated concerning the Miss U.M.O. Pageant

Mise en place d’un système de veille documentaire: comment capitaliser des ressources numériques spécifiques et optimiser leur accès au "Centre de documentation et bibliothèque" du CNP

Dans le cadre d’une démarche de formation continue, les collaborateurs du CNP - Centre neuchâtelois de psychiatrie (professionnels de la santé) ont émis le souhait de pouvoir accéder à des ressources documentaires numériques (ou références bibliographiques) fiables, actualisées et pertinentes, liées au domaine de la santé mentale. Ayant perçu ce besoin, pour y répondre et capitaliser efficacement les ressources sélectionnées en assurant un accès aisé (rapide et simplifié) à ces dernières, j’ai prévu de mettre en place un système de veille documentaire. Celui-ci doit assurer l’exhaustivité des ressources proposées, un accès immédiat, simultané et ininterrompu aux connaissances professionnelles. Les résultats recueillis par le biais de ce système de médiation numérique viendront régulièrement alimenter une base de références consultable par l’ensemble des collaborateurs. Les ressources proposées seront organisées selon des thèmes prédéfinis (indexation) et rediffusées de manière automatisée. Le développement de ce service de veille dont le présent travail se limite à décrire une phase de test (lié à un thème précis), nécessitera de passer par plusieurs étapes qui sont « l’analyse de l’environnement et des besoins » (ciblage et périmètre de veille), « le déploiement du système » (paramétrage, collecte, analyse, traitement, capitalisation, mise à disposition et diffusion) et « l’évaluation du système » (pertinence, maintien et réajustement)

[Turner-like syndrome: a case report].

A prepubescent 11 year-old girl came to our attention for short stature. Auxological evaluation showed peculiar phenotype. In order to exclude Turner syndrome standard karyotype was performed with normal result. Because of anemia and selective deficiency of the erythroid lineage further investigations were performed and a diagnosis of Blackfan-Diamond anemia was made

Relative expression of TAp73 and ΔNp73 isoforms

The transcription factor p73 belongs to the p53 family of tumour suppressors and similar to other family members, transcribed as different isoforms with opposing pro- and anti-apoptotic functions. Unlike p53, p73 mutations are extremely rare in cancers. Instead, the pro-apoptotic activities of transcriptionally active p73 isoforms are commonly inhibited by over-expression of the dominant negative p73 isoforms. Therefore the relative ratio of different p73 isoforms is critical for the cellular response to a chemotherapeutic agent. Here, we analysed the expression of N-terminal p73 isoforms in cell lines and mouse tissues. Our data showed that the transcriptionally competent TAp73 isoform is abundantly expressed in cancer cell lines compared to the dominant negative ΔNp73 isoform. Interestingly, we detected higher levels of ΔNp73 in some mouse tissues, suggesting that ΔNp73 may have a physiological role in these tissues

Cross-sectional and prospective study of the effects of GH therapy on metabolic panel in children with GH deficiency

Background: Numerous studies have shown that GH, in addition to promoting linear growth, exerts a key role in many metabolic processes. However, there are only few studies aiming at evaluating the metabolic panel of children with GH deficiency (GHD). The aims of the study were: to verify the presence of metabolic alterations in GHD children in comparison with age-matched controls and to check the possible effects of two year GH therapy on the metabolic parameters in GHD. Study design: cross-sectional and prospective; one center experience Population and Methods: We enrolled 32 pediatric GHD patients (group A) and 33 sex- and age-matched healthy controls (group B). Baseline serum assays (lipid, insulin, glucose) were performed in both groups. GHD children underwent replacement therapy with GH. The same assays were repeated after 12 and 24 months of GH treatment. Results: No differences, in basal assays were found between the two groups. In group A, after initiation of GH, there was a significant increase of basal insulin and HOMA- insulin resistance (IR) index (p <0.001). In children with severe GHD (peak GH <3 ng / ml), after beginning of GH therapy a significant improvement in the lipid profile was found (p < 0.05). Conclusions: a) At the time of diagnosis GHD children had a metabolic picture that was not different from non- GHD group; b) in children with severe GHD, the metabolic profile showed a trend towards at improvement after the initiation of replacement therapy with GH, with beneficial effects in terms of total cholesterol, LDL cholesterol and cardiovascular risk indices; c) GHD patients with unfavorable metabolic profile (high BMI and hypercholestorolemia) need a monitoring of glucose metabolism by periodical evaluations of insulin and HOMA – IR

Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr(402)His polymorphism

Purpose: To investigate the influence of the Factor H (CFH) Tyr(402)His polymorphism on the plasma levels of the alternative pathway proteins CFH, C3, Factor B (FB), Factor D (FD), and Factor I (FI) and the inflammatory marker C-reactive protein (CRP) in 119 patients with age-related macular degeneration (AMD) and 152 unrelated control individuals. Methods: Patients with AMD and the control group were separated according to CFH polymorphism, age, and gender. Plasma complement proteins and CRP concentrations were determined with enzyme-linked immunosorbent assay, immunodiffusion, or nephelometry. Results: Significant differences in the concentrations of FD and FI were observed between the patients with AMD and the control individuals. We observed significantly reduced FD plasma levels in patients with AMD. We also identified a significant decrease in CFH plasma levels in female patients with AMD in relation to female controls. Plasma FI levels were significantly increased in patients with AMD compared to the control group. Regarding gender, a significant increase in FI plasma levels was observed in male patients. Finally, we found no significant correlation between the CFH Tyr(402)His polymorphism and the CFH, C3, FB, FD, FI, and CRP plasma levels. Conclusions: Patients with AMD present altered levels of FD and FI in a manner independent of this CFH polymorphism, and gender apparently contributes to the plasma levels of these two proteins in patients with AMD and control individuals.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)FAPESPFAPES

p73: a multifunctional protein in neurobiology

p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus. TAp73 expression increases in parallel with neuronal differentiation and its ectopic expression induces neurite outgrowth and expression of neuronal markers in neuroblastoma cell lines and neural stem cells, suggesting that it has a pro-differentiation role. In contrast, ΔNp73 shows a survival function in mature cortical neurons as selective ΔNp73 null mice have reduced cortical thickness. Recent evidence has also suggested that p73 isoforms are deregulated in neurodegenerative pathologies such as Alzheimer’s disease, with abnormal tau phosphorylation. Thus, in addition to its increasingly accepted contribution to tumorigenesis, the p73 subfamily also plays a role in neuronal development and neurodegeneration

Glutamine metabolism, the Achilles heel for medulloblastoma tumor

Children with Cancer UK fellowship (Reference 2014/178