Novel Key Ingredients in Urinary Tract Health-The Role of D-mannose, Chondroitin Sulphate, Hyaluronic Acid, and N-acetylcysteine in Urinary Tract Infections (Uroial PLUS®)

: Urinary tract infections represent a common and significant health concern worldwide. The high rate of recurrence and the increasing antibiotic resistance of uropathogens are further worsening the current scenario. Nevertheless, novel key ingredients such as D-mannose, chondroitin sulphate, hyaluronic acid, and N-acetylcysteine could represent an important alternative or adjuvant to the prevention and treatment strategies of urinary tract infections. Several studies have indeed evaluated the efficacy and the potential use of these compounds in urinary tract health. In this review, we aimed to summarize the characteristics, the role, and the application of the previously reported compounds, alone and in combination, in urinary tract health, focusing on their potential role in urinary tract infections

MEDIATE - Molecular DockIng at homE: Turning collaborative simulations into therapeutic solutions

IntroductionCollaborative computing has attracted great interest in the possibility of joining the efforts of researchers worldwide. Its relevance has further increased during the pandemic crisis since it allows for the strengthening of scientific collaborations while avoiding physical interactions. Thus, the E4C consortium presents the MEDIATE initiative which invited researchers to contribute via their virtual screening simulations that will be combined with AI-based consensus approaches to provide robust and method-independent predictions. The best compounds will be tested, and the biological results will be shared with the scientific community.Areas coveredIn this paper, the MEDIATE initiative is described. This shares compounds' libraries and protein structures prepared to perform standardized virtual screenings. Preliminary analyses are also reported which provide encouraging results emphasizing the MEDIATE initiative's capacity to identify active compounds.Expert opinionStructure-based virtual screening is well-suited for collaborative projects provided that the participating researchers work on the same input file. Until now, such a strategy was rarely pursued and most initiatives in the field were organized as challenges. The MEDIATE platform is focused on SARS-CoV-2 targets but can be seen as a prototype which can be utilized to perform collaborative virtual screening campaigns in any therapeutic field by sharing the appropriate input files

Can a Surgical Technique Be a Risk for Post-tonsillectomy Haemorrhage? Our Point of View

Objectives: Controversies have recently arisen regarding post-operative haemorrhagic complications in relation to the surgical procedures ad- opted for tonsillectomy. The authors set out to verify the relationship between surgical techniques and post-operative haemorrhage based on the analysis of data derived from multi-centric studies. Results: Eight multi-centric studies were analysed. The mean frequency of post-tonsillectomy haemorrhage was: 1.13% for primary haemorrhage, 5.37% for secondary haemorrhage, and 6.5% as overall for cold dissection with cold haemostasis; 0.99% for primary haemorrhage, 2.91% for secondary haemorrhage, and 3.9% as overall for cold dissection with hot haemostasis; 1.31% for primary haemorrhage, 7.38% for secondary haemorrhage, and 8.69% as overall for hot dissection with hot haemostasis. The statistical comparison did not show significant differences between the frequencies of post-tonsillectomy primary, secondary, and total haemorrhage in relation to the surgical techniques employed. Conclusion: A great variability in the frequency of haemorrhagic complications reported in the selected articles was found, regardless of the surgical technique. These findings, together with the lack of a statistically significant difference in post-tonsillectomy haemorrhage between the techniques employed, must be carefully considered by professionals involved in health organizations in clinical wards and the relative problems linked to medical liability

Surgical techniques and post-tonsillectomy haemorrhage.

Purpose: Some controversies have recently arisen regarding the frequency of post-operative haemorrhagic complications in relation to the surgical procedures adopted for tonsillectomy. The authors set out to verify the relationship between different surgical techniques and post-operative haemorrhage based on the analysis of data derived from multi-centric studies appeared in the last fifteen years. Materials and methods: Multi-centric English and Italian studies pertaining to the frequency of post-tonsillectomy haemorrhage secondary to different surgical techniques published between 2000 and 2015 were selected. The data relevant to post-surgical haemorrhagic complications were elaborated by ANOVA test. Results: Eight multi-centric studies were analysed. The mean frequency of post-tonsillectomy haemorrhage was: 1.13% for primary haemorrhage, 5.37% for secondary haemorrhage and 6.5% as overall for cold dissection and cold haemostasis; 0.99% for primary haemorrhage, 2.91% for secondary haemorrhage and 3.9% as overall for cold dissection with hot haemostasis; 1.31% for primary haemorrhage, 7.38% for secondary haemorrhage and 8.69% as overall for hot dissection with hot haemostasis. Statistical comparison did not show significant differences between the frequencies of post-tonsillectomy primary, secondary and total haemorrhage in relation to the surgical techniques employed. Conclusion: A great variability in the frequency of haemorrhagic complications reported in the selected articles was found, regardless of the surgical technique employed. These findings, together with lack of a statistically significant difference in post-tonsillectomy haemorrhage between the techniques employed, must be carefully considered by professionals involved in health organization in clinical wards and the relative problems linked to medical liability

Can a surgical tecnique be a risk for post-tonsillectomy hemorrage? Our point of view

Objectives: Some controversies have recently arisen regarding the frequency of post-operative haemorrhagic complications in relation to the surgical procedures adopted for tonsillectomy. The authors set out to verify the relationship between different surgical techniques and post-operative haemorrhage based on the analysis of data derived from multi-centric studies appeared during the last fifteen years. Materials and Methods: Multi-centric English and Italian studies pertaining to the frequency of post-tonsillectomy haemorrhage secondary to different surgical techniques published between 2000 and 2015 were selected. The data relevant to post-surgical haemorrhagic complications were elaborated by ANOVA test. Results: Eight multi-centric studies were analysed. The mean frequency of post-tonsillectomy haemorrhage was: 1.13% for primary haemorrhage, 5.37% for secondary haemorrhage, and 6.5% as overall for cold dissection with cold haemostasis; 0.99% for primary haemorrhage, 2.91% for secondary haemorrhage, and 3.9% as overall for cold dissection with hot haemostasis; 1.31% for primary haemorrhage, 7.38% for secondary haemorrhage, and 8.69% as overall for hot dissection with hot haemostasis. The statistical comparison did not show significant differences between the frequencies of post-tonsillectomy primary, secondary, and total haemorrhage in relation to the surgical techniques employed. Conclusion: A great variability in the frequency of haemorrhagic complications reported in the selected articles was found, regardless of the surgical technique employed. These findings, together with the lack of a statistically significant difference in post-tonsillectomy haemorrhage between the techniques employed, must be carefully considered by professionals involved in health organizations in clinical wards and the relative problems linked to medical liability