Online Applied Problem-Based Learning to Determine the Shelf Life of an on-Site Solution of Refrigerated Drug

A problem-based online learning (PBe-L) teaching sequence was designed for calculating the shelf life (expiration date) of an on-site solution of refrigerated drug as part of activities of a Pharmaceutical Physical Chemistry course of Pharmacy major at FES Cuautitlán UNAM in Mexico. The teacher presents students the problem, a group collaborative activity is carried out to search for information in PBL cycles. Students are then shown a virtual experiment that includes experimental results. Another group collaborative activity is carried out for the search of information, for the procedural analysis of the results. Applying knowledge and understanding of the topics of chemical kinetics, temperature effect on the rate of chemical reactions and drug degradation reactions, etc., students solve the problem. Hake's factor was determined for the conceptual gain. A Likert-type satisfaction survey was conducted and compared to the results of a group that was applied to the PBL strategy in person. At the end of the sequence students achieved recognition, comprehension and application learnings and conceptual gain was high. Allowing an integration of its cognitive framework of kinetics topics

The SpatialCIM methodology for spatial document coverage disambiguation and the entity recognition process aided by linguistic techniques.

Abstract. Nowadays it is becoming more usual for users to take into account the geographical localization of the documents in the retrieval information process. However, the conventional retrieval information systems based on key-word matching do not consider which words can represent geographical entities that are spatially related to other entities in the document. This paper presents the SpatialCIM methodology, which is based on three steps: pre-processing, data expansion and disambiguation. In the pre-processing step, the entity recognition process is carried out with the support of the Rembrandt tool. Additionally, a comparison between the performances regarding the discovery of the location entities in the texts of the Rembrandt tool against the use of a controlled vocabulary corresponding to the Brazilian geographic locations are presented. For the comparison a set of geographic labeled news covering the sugar cane culture in the Portuguese language is used. The results showed a F-measure value increase for the Rembrandt tool from 45% in the non-disambiguated process to 0.50 after disambiguation and from 35% to 38% using the controlled vocabulary. Additionally, the results showed the Rembrandt tool has a minimal amplitude difference between precision and recall, although the controlled vocabulary has always the biggest recall values.GeoDoc 2012, PAKDD 2012

Discovering the spatial coverage of the documents through the SpatialCIM Methodology.

The main focus of this paper is to present the SpatialCIM methodology to identify the spatial coverage of the documents in the Brazilian geographic area. This methodology uses a linguistic tool to assist in the entity recognition process. The linguistic tool classifies the recognized entities as person, organization, time and localization, among others. The localization entities are checked using a geographic information system (GIS) in order to extract the Brazilian entity geographic paths. If there are multiple geographic paths for a single entity, the disambiguation process is carried out. This process attempts to locate the best geographic path for an entity considering all the geographic entities in the text. Another important objective of this paper is to show that the disambiguation process improves the geographic classification of the documents considering the obtained geographic paths. The validation process considers a set of news previously labeled by an expert and compared with the results of the disambiguated and non-disambiguated geographic paths. The results showed that the disambiguation process improves the classification compared with the classification without disambiguation. Keywords: Ambiguity problem resolution, spatial coverage identification, toponym resolution

Large scale patterns of genetic variation and differentiation in sugar maple from tropical Central America to temperate North America

© 2015 Vargas-Rodriguez et al. Background: Geological events in the latter Cenozoic have influenced the distribution, abundance and genetic structure of tree populations in temperate and tropical North America. The biogeographical history of temperate vegetation that spans large ranges of latitude is complex, involving multiple latitudinal shifts that might have occurred via different migration routes. We determined the regional structuring of genetic variation of sugar maple (Acer saccharum subsp. saccharum) and its only subspecies in tropical America (Acer saccharum subsp. skutchii) using nuclear and chloroplast data. The studied populations span a geographic range from Maine, USA (46°N), to El Progreso, Guatemala (15°N). We examined genetic subdivisions, explored the locations of ancestral haplotypes, analyzed genetic data to explore the presence of a single or multiple glacial refugia, and tested whether genetic lineages are temporally consistent with a Pleistocene or older divergence. Results: Nuclear and chloroplast data indicated that populations in midwestern USA and western Mexico were highly differentiated from populations in the rest of the sites. The time of the most recent common ancestor of the western Mexico haplotype lineage was dated to the Pliocene (5.9 Ma, 95 % HPD: 4.3-7.3 Ma). Splits during the Pleistocene separated the rest of the phylogroups. The most frequent and widespread haplotype occurred in half of the sites (Guatemala, eastern Mexico, southeastern USA, and Ohio). Our data also suggested that multiple Pleistocene refugia (tropics-southeastern USA, midwestern, and northeastern USA), but not western Mexico (Jalisco), contributed to post-glacial northward expansion of ranges. Current southern Mexican and Guatemalan populations have reduced population sizes, genetic bottlenecks and tend toward homozygosity, as indicated using nuclear and chloroplast markers. Conclusions: The divergence of western Mexican populations from the rest of the sugar maples likely resulted from orographic and volcanic barriers to gene flow. Past connectivity among populations in the southeastern USA and eastern Mexico and Guatemala possible occurred through gene flow during the Pleistocene. The time to the most common ancestor values revealed that populations from the Midwest and Northeast USA represented different haplotype lineages, indicating major divergence of haplotypes lineages before the Last Glacial Maximum and suggesting the existence of multiple glacial refugia

Effectiveness of Two Ruminally Protected Methionine Sources for Lactating Dairy Cows

Two sources of ruminally protected methionine were tested for their ability to provide available methionine to lactating dairy cattle. Based on milk protein yield and milk protein percent, NTP-1401 (an unreleased product from Novus International, Inc., St. Charles, MO) and Smartamine (Adisseo, αretta, GA) provided similar amounts of available methionine to the cows. These two products led to different methioninerelated compounds appearing in blood plasma, suggesting that they contained different methionine precursors

Determinación de presencia de enfermedades infecciosas en hatos doble propósito, Vereda Balcanes, Florencia, Caquetá

En doce(12)hatos de la vereda Balcanes,aledaños a la granja del mismo nombre,de propiedad de la Universidad de la Amazonia, se desarrolló el estudio sobre la presencia de enfermedades infecciosas (parainfluenza bovina tipo3 (PI3), diarrea viral bovina

Relationship between Dyslipidemia and Physical Activity in Mexican Children

Purpose: The purpose of this research was to determine the relationship between physical activity and lipid levels in children 10 to 13 years of age living in Durango, Mexico. Method: Cross-sectional study performed in 823 children (n=428, 52% boys; n=395, 48% girls) enrolled in nine elementary schools. Physical activity was monitored in two ways: a) a questionnaire was used to obtain information about physical activity done in the previous week, and b) steps were counted for 24 hours with a Yamax SW-200 pedometer. A subsample of 425 children provided serum samples to determine total-cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and triglycerides (TG). Results: Over half (52.9%) participated in a sports team inside or outside of school; most (90.9%) reported one sport, with few (9.1%) reporting 2-3 sports. The most commonly reported vigorous PA was: soccer (33%), basketball (24%), jogging (8-12 km/h) (23%), volleyball (17%) and others (3%). Those who participated in a sports team had higher levels of HDL-C and lower TG. Participation in 2 or 3 sports reduced TG levels just over 20%. Boys who reported 30 minutes or more per day of vigorous activity had lower triglyceride levels than those who reported less (p = 0.020). Boys accumulated significantly more steps per day (m=17,030 ± 6444) than girls (m=12,991± 5316; p \u3c 0.001). The prevalence of lipid abnormalities was higher in children with fewer steps. Hypercholesterolemia was lower in boys with the highest number of steps (p = 0.044), in girls the differences were not statistically significant. Hypertriglyceridemia in both sexes was lower in the group with the highest number of steps (

A Fungal Effector With Host Nuclear Localization and DNA-Binding Properties Is Required for Maize Anthracnose Development

Plant pathogens have the capacity to manipulate the host immune system through the secretion of effectors. We identified 27 putative effector proteins encoded in the genome of the maize anthracnose pathogen Colletotrichum graminicola that are likely to target the host’s nucleus, as they simultaneously contain sequence signatures for secretion and nuclear localization. We functionally characterized one protein, identified as CgEP1. This protein is synthesized during the early stages of disease development and is necessary for anthracnose development in maize leaves, stems, and roots. Genetic, molecular, and biochemical studies confirmed that this effector targets the host’s nucleus and defines a novel class of double-stranded DNA-binding protein. We show that CgEP1 arose from a gene duplication in an ancestor of a lineage of monocot-infecting Colletotrichum spp. and has undergone an intense evolution process, with evidence for episodes of positive selection. We detected CgEP1 homologs in several species of a grass-infecting lineage of Colletotrichum spp., suggesting that its function may be conserved across a large number of anthracnose pathogens. Our results demonstrate that effectors targeted to the host nucleus may be key elements for disease development and aid in the understanding of the genetic basis of anthracnose development in maize plants.Fil: Vargas, Walter Alberto. Universidad de Salamanca; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanz Martín, José M.. Universidad de Salamanca; EspañaFil: Rech, Gabriel E.. Universidad de Salamanca; EspañaFil: Armijos Jaramillo, Vinicio D.. Universidad de Salamanca; EspañaFil: Rivera Rodriguez, Lina Patricia. Universidad de Salamanca; EspañaFil: Echeverria, María de Las Mercedes. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; ArgentinaFil: Díaz Mínguez, José M.. Universidad de Salamanca; EspañaFil: Thon, Michael R.. Universidad de Salamanca; EspañaFil: Sukno, Serenella A.. Universidad de Salamanca; Españ

Crecimiento urbano e impacto en el ruido ambiental de la delegación Azcapotzalco. Un análisis cartográfico

El ruido ambiental en las grandes ciudades es hoy motivo de preocupación, debido a que afecta de manera importante a la población en general. La gran cantidad de actividades que día a día se llevan a cabo en ellas, trae consigo el uso de tecnologías que a su vez generan niveles importantes de ruido. El ruido por tráfico vehicular es el que mayor presencia tiene en las ciudades, ya que este es constante y la tendencia al crecimiento de vialidades y número de vehículos también lo es. El crecimiento urbano a lo largo del tiempo ha ido vinculado con el crecimiento del uso de tecnologías que buscan aliviar o facilitar la vida de los ciudadanos, y el trafico vehicular está implicito en este tipo de acciones. El desarrollo de la ciudad de México ha sido muy constrastante entre finales del siglo XIX y principios del siglo XXI y el impacto que este hecho ha tenido en la presencia del ruido ambiental en ella es notable. En este trabajo se realiza un estudio de este hecho a través de la comparación de la evolución urbana en mapas históricos de la Delegación Azcapotzalco en cinco épocas: 1899, 1929, 1942, 1973 y 2010, y de la construcción de mapas de ruido de la demarcación.The environmental noise we find in the big cities are a matter of concern now at days. It a ffects the city’s population in a very important way. The amounts of activities that are done in these cities each day bring with them the use of technologies that generate great levels of noise. The noise caused by the vehicular trafic is the one with more importance in the city, since it’s continuous and there is a growth in the number of vehicles every day. The urban growth within time has been linked to the increase in the use of technologies that aim to relieve and make citizens life easier and vehicular trafic is implicit in this type of actions. The development of Mexico City has been very contrasting between the end of the XIX century and beginning of the XXI. The impact that this development has had in terms of environmental noise is noticeable. In this essay we make a study about this fact through the comparison of the urban evolution in historical maps of “Azcapotzalco’s” Delegation during ve years: 1899, 1929, 1942, 1973 and 2010, and the creation of noise and demarcation maps