Precision stellar radial velocity measurements with FIDEOS at the ESO 1-m telescope of La Silla

We present results from the commissioning and early science programs of FIDEOS, the new high-resolution echelle spectrograph developed at the Centre of Astro Engineering of Pontificia Universidad Catolica de Chile, and recently installed at the ESO 1m telescope of La Silla. The instrument provides spectral resolution R = 43,000 in the visible spectral range 420-800 nm, reaching a limiting magnitude of 11 in V band. Precision in the measurement of radial velocity is guaranteed by light feeding with an octagonal optical fibre, suitable mechanical isolation, thermal stabilisation, and simultaneous wavelength calibration. Currently the instrument reaches radial velocity stability of = 8 m/s over several consecutive nights of observation

Self-care in pediatric patients with chronic conditions: A systematic review of theoretical models

Background: To improve outcomes in children and young adults (CYAs) with chronic conditions, it is important to promote self-care through education and support. Aims: (1) to retrieve the literature describing theories or conceptual models of self-care in CYAs with chronic conditions and (2) to develop a comprehensive framework. Methods: A systematic literature search was conducted on nine databases, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All peer-reviewed papers describing a theory or a conceptual model of self-care in CYAs (0-24 years) with chronic conditions were included. Results: Of 2674 records, 17 met the inclusion criteria. Six papers included a theory or a model of self-care, self-management, or a similar concept. Six papers developed or revised pre-existing models or theories, while five papers did not directly focus on a specific model or a theory. Patients were CYAs, mainly with type 1 diabetes mellitus and asthma. Some relevant findings about self-care in CYAs with neurocognitive impairment and in those living with cancer may have been missed. Conclusions: By aggregating the key elements of the 13 self-care conceptual models identified in the review, we developed a new overarching model emphasizing the shift of self-care agency from family to patients as main actors of their self-management process. The model describes influencing factors, self-care behaviors, and outcomes; the more patients engaged in self-care behaviors, the more the outcomes were favorable

Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer.

PURPOSE: Anthracyclines and taxanes are considered the standard for neoadjuvant chemotherapy of breast cancer, although they are often associated with serious side effects and wide variability of individual response. In this study, we analyzed the value of topoisomerase II alpha (TOP2A) and transducin-like enhancer of split 3 (TLE3) as predictive markers of response to therapy with anthracyclines and taxanes. MATERIALS AND METHODS: TOP2A and TLE3 protein expressions were evaluated using immunohistochemistry on 28 samples, obtained by core needle biopsy in patients with locally advanced breast carcinoma, subsequently subjected to epirubicin- and paclitaxel-based neoadjuvant chemotherapy. The immunohistochemical staining was correlated with the clinical response measured by the tumor size reduction evaluated by breast magnetic resonance imaging, prior and after chemotherapy, and by pathologic evaluation of the surgical specimen. RESULTS: Neoadjuvant chemotherapy achieved a size reduction in 26/28 tumors (92.9%), with an average percentage decrease of 45.6%. A downstaging was achieved in 71.4% of the cases of locally advanced carcinoma. TOP2A positivity was correlated with a greater reduction in tumor diameter (P=0.06); negative staining for TLE3 was predictive of a better response to neoadjuvant chemotherapy (P=0.07). A higher reduction in tumor diameter (P=0.03) was also found for tumors that were concurrently TLE3-negative and TOP2A-positive. CONCLUSION: TOP2A and TLE3 showed a correlation with response to neoadjuvant chemotherapy. While TOP2A is a well-known marker of response to anthracyclines-based chemotherapy, TLE3 is a new putative predictor of response to taxanes. Data from the current study suggest that TOP2A and TLE3 warrant further investigation in a larger series as predictors of response to neoadjuvant chemotherapy for locally advanced breast carcinoma

Power-effective scanning with AODs for 3D optogenic applications

Two-photon (2P) excitation is a cornerstone approach widely employed in neuroscience microscopy for deep optical access and sub-micrometric-resolution light targeting into the brain. However, besides structural and functional imaging, 2P optogenetic stimulations are less routinary, especially in 3D. This is because of the adopted scanning systems, often feebly effective, slow and mechanically constricted. Faster illumination can be achieved through acousto-optic deflectors (AODs) although their applicability to large volumes excitation has been limited by large efficiency drop along the optical axis. Here, we present a new AOD-based scheme for 2P 3D scanning that improves the power delivery between different illumination planes. We applied this approach to photostimulate an optogenetic actuator in zebrafish larvae, demonstrating the method efficiency observing increased activity responses and uniform activation probabilities from neuronal clusters addressed in the volume. This novel driving scheme can open to new AOD applications in neuroscience, allowing more effective 3D interrogation in large neuronal networks

Pediatric nurses in pediatricians' offices: a survey for primary care pediatricians

Background: The role played by nurses in caring for children in pediatricians' officies in the community is crucial to ensure integrated care. In Italy, pediatricians are responsible for the health of children aged 0-14 years living in the community. This study aimed to describe Italian primary care pediatricians' opinions about the usefulness of several nursing activities that pediatric nurses could perform in pediatricians' offices. Methods: An online survey with pediatricians working in primary care in Italy was conducted between April-December 2018. A 40-item questionnaire was used to assess four types of nursing activities: clinical care, healthcare education, disease prevention, and organizational activities. The answers ranged from 1 (not useful at all) to 6 (very useful). Moreover, three open-ended questions completed the questionnaire. Results: Overall, 707 pediatricians completed the online survey. Participants were mainly female (63%), with a mean age of 57.74 (SD = 6.42). The presence of a pediatric nurse within the pediatrician's office was considered very useful, especially for healthcare education (Mean 4.90; SD 1.12) and disease prevention (Mean 4.82; SD 1.11). Multivariate analysis confirmed that pediatricians 'with less working experience', 'having their office in a small town', and 'collaborating with a secretary and other workers in the office' rated the nurse's activities significantly more useful. Conclusions: A pediatric nurse in the pediatrician's office can significantly contribute to many activities for children and their families in the community. These activities include clinical care, healthcare education, disease prevention, and the organizational processes of the office. Synergic professional activity between pediatricians and pediatric nurses could ensure higher health care standards in the primary care setting

ISM enrichment and local pollution in dwarf galaxies

The fate of metals after they are released in starburst episodes is still unclear. What phases of the interstellar medium are involved, in which timescales? Evidence has grown over the past few years that the neutral phase of blue compact dwarf (BCD) galaxies may be metal- deficient as compared to the ionized gas of their HII regions. These results have strong implications for our understanding of the chemical evolution of galaxies. We review here the main results and the main caveats in the abundance determination from far-UV absorption-lines. We also discuss possible scenarios concerning the journey of metals into the interstellar medium, or even their ejection from the galaxy into the intergalactic medium.Comment: Long version of a proceeding for the conference "A Universe of Dwarf Galaxies: Observations, Theories, Simulations" held in Lyon, France (14th-18th, June 2010

Clustered Star Formation in W75 N

We present 2" to 7" resolution 3 mm continuum and CO(J=1-0) line emission and near infrared Ks, H2, and [FeII] images toward the massive star forming region W75 N. The CO emission uncovers a complex morphology of multiple, overlapping outflows. A total flow mass of greater than 255 Msun extends 3 pc from end-to-end and is being driven by at least four late to early-B protostars. More than 10% of the molecular cloud has been accelerated to high velocities by the molecular flows (> 5.2 km/s relative to v{LSR}) and the mechanical energy in the outflowing gas is roughly half the gravitational binding energy of the cloud. The W75 N cluster members represent a range of evolutionary stages, from stars with no apparent circumstellar material to deeply embedded protostars that are actively powering massive outflows. Nine cores of millimeter-wavelength emission highlight the locations of embedded protostars in W75 N. The total mass of gas & dust associated with the millimeter cores ranges from 340 Msun to 11 Msun. The infrared reflection nebula and shocked H2 emission have multiple peaks and extensions which, again, suggests the presence of several outflows. Diffuse H2 emission extends about 0.6 parsecs beyond the outer boundaries of the CO emission while the [FeII] emission is only detected close to the protostars. The infrared line emission morphology suggests that only slow, non-dissociative J-type shocks exist throughout the pc-scale outflows. Fast, dissociative shocks, common in jet-driven low-mass outflows, are absent in W75 N. Thus, the energetics of the outflows from the late to early B protostars in W75 N differ from their low-mass counterparts -- they do not appear to be simply scaled-up versions of low-mass outflows.Comment: Astrophysical Journal, in press. 23 pages plus 10 figures (jpg format). See http://www.aoc.nrao.edu/~dshepher/science.shtml for reprint with full resolution figure

A Near-Infrared Stellar Census of the Blue Compact Dwarf Galaxy VII~Zw~403

We present near-infrared single-star photometry for the low-metallicity Blue Compact Dwarf galaxy VII~Zw~403. We achieve limiting magnitudes of F110W~$\approx$~25.5 and F160W~$\approx$~24.5 using one of the NICMOS cameras with the HST equivalents of the ground-based J and H filters. The data have a high photometric precision (0.1 mag) and are $>95$% complete down to magnitudes of about 23, far deeper than previous ground-based studies in the near-IR. The color-magnitude diagram contains about 1000 point sources. We provide a preliminary transformation of the near-IR photometry into the ground system...Comment: Accepted for publication by the AJ, preprint has 49 pages, 2 tables, and 16 figure