Investigation into hearing impairment among Indigenous prisoners within the Northern Territory Correctional Services

This report investigates the implications of hearing impairment among the Indigenous prisoners in Northern Territory Correctional Services. The results of the study found significant hearing loss among Indigenous prisoners, contributing to a breakdown of communication between inmates and prison officers. There is further discussion about the implications of hearing loss for correctional services and recommendations for the use of hearing amplification devices to reduce communication difficulties and improve rehabilitation outcomes

Dysregulation of the immune response in severe sepsis

Sepsis is systemic expression of a generalized activation of the host's innate immunity as a result of varied types of insults. This expression involves a cellular inflammatory response that has both proinflammatory and antiinflammatory components, the primary trigger for which is an intracellular oxidative stress, induced by receptor-mediated transmembrane signal transduction or direct noxious injury. Sepsis reflects the interaction between pro- and anti-inflammatory intracellular mechanisms, the uncontrolled activation of which leads to cell exhaustion, organ dysfunction, and death. Successful clinical trials of novel treatments for the management of severe sepsis share a common ability to down-regulate this overall response, restoring normal proinflammatory responsiveness and mitochondrial energetic function