Application of Risk Informed Decision Making to Highly Reliable Three Dimensionally Woven Thermal Protection System for Mars Sample Return

The NASA Risk Informed Decision Making process is used to assess a trade space of three dimensionally woven thermal protection systems for application to the Mars Sample Return Earth Entry Vehicle. Candidate architectures are assessed based on mission assurance, technical development, cost, and schedule risk. Assessment methodology differed between the architectures, utilizing a four-point quantitative scale for mission assurance and technical development and highly tailored PERT techniques for cost and schedule. Risk results are presented, in addition to a review of RIDM effectiveness for this application

The incantations of the EU organised crime policy making

This article provides an analysis of the knowledge base of organised crime assessments and policy making in the European Union. It is argued that the current European organised crime (threat) assessments are no reliable and relevant instruments to make meaningful statements about organised crime. The data collection system of the current assessments is defective and to a large extent dependant on what Member States decide to disclose and not based on clear developed concepts, definitions and methods. There is no discernable "counting unit" as a basis for deducing threats or risks. More fundamental: the definition or criteria list used is defective, providing no basis for further deductions or conclusions. The conclusions of the open versions of the European reports are of a very general nature, not substantially different from what can be found in open sources. Though European decision making claims to be founded on these assessments, it looks more like a ritual incantation than a knowledge based process

Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range

Background: Research involving gene expression profiling and clinical applications, such as diagnostics and prognostics, often require a DNA array platform that is flexibly customisable and cost-effective, but at the same time is highly sensitive and capable of accurately and reproducibly quantifying the transcriptional expression of a vast number of genes over the whole transcriptome dynamic range using low amounts of RNA sample. Hereto, a set of easy-to-implement practical optimisations to the design of cDNA-based nylon macroarrays as well as sample (33)P-labeling, hybridisation protocols and phosphor screen image processing were analysed for macroarray performance. Results: The here proposed custom macroarray platform had an absolute sensitivity as low as 50,000 transcripts and a linear range of over 5 log-orders. Its quality of identifying differentially expressed genes was at least comparable to commercially available microchips. Interestingly, the quantitative accuracy was found to correlate significantly with corresponding reversed transcriptase - quantitative PCR values, the gold standard gene expression measure (Pearson's correlation test p < 0.0001). Furthermore, the assay has low cost and input RNA requirements (0.5 mu g and less) and has a sound reproducibility. Conclusions: Results presented here, demonstrate for the first time that self-made cDNA-based nylon macroarrays can produce highly reliable gene expression data with high sensitivity and covering the entire mammalian dynamic range of mRNA abundances. Starting off from minimal amounts of unamplified total RNA per sample, a reasonable amount of samples can be assayed simultaneously for the quantitative expression of hundreds of genes in an easily customisable and cost-effective manner

The properties of kaonic nuclei in relativistic mean-field theory

The static properties of some possible light and moderate kaonic nuclei, from C to Ti, are studied in the relativistic mean-field theory. The 1s and 1p state binding energies of $K^-$ are in the range of $73\sim 96$ MeV and $22\sim 63$ MeV, respectively. The binding energies of 1p states increase monotonically with the nucleon number A. The upper limit of the widths are about $42\pm 14$ MeV for the 1s states, and about $71\pm 10$ MeV for the 1p states. The lower limit of the widths are about $12\pm 4$ MeV for the 1s states, and $21\pm 3$ MeV for the 1p states. If $V_{0}\leq 30$ MeV, the discrete $K^-$ bound states should be identified in experiment. The shrinkage effect is found in the possible kaonic nuclei. The interior nuclear density increases obviously, the densest center density is about $2.1\rho_{0}$.Comment: 9 pages, 2 tables and 1 figure, widths are considered, changes a lo

An Analysis of the Vascular Flora of Annapolis Heathlands, Nova Scotia

A description and analysis of the vascular plant composition of heathlands in the Annapolis valley were undertaken to provide a basis for biodiversity preservation within a system of protected sites. Species presence and abundance were recorded at 23 remnant sites identified using topographic maps, air photos, and Nova Scotia Department of Natural Resources records. A total of 126 species was recorded, of which 94 were native and 31 introduced. The Annapolis heathland remnants are strongly dominated by Corema conradii with Comptonia peregrina, Vaccinium angustifolium and Pteridium aquilinum var. latiusculum. A number of species, including Solidago bicolor, Carex tonsa var. rugosperma, Dichanthelium depauperatum, Lechea intermedia, Melampyrum lineare, and Rubus hispidus, were characteristic of heathland remnants, although they usually contributed little to the total cover. The most frequent alien species were Hieracium pilosella and Festuca filiformis, but Pinus sylvestris, present at 7 of 18 sites, appeared to have the greatest impact in displacing native species. Species listed as at risk and sensitive in Nova Scotia, including Helianthemun canadense, Hudsonia ericoides and Viola sagittata var. ovata, occur in open disturbed sand in the Corema heathlands. Distinctive patterns of variation occur in several species and variation in crop relatives is noted with particular reference to the genera Rubus (blackberries), Amelanchier (Juneberries, Saskatoon) and Vaccinium (Blueberries). The available evidence suggests that the heathlands and sandy barrens in the Annapolis valley differ from those further west in Canada and from anthropogenic and coastal heathlands of Nova Scotia in their species composition including particularly the presence of Corema conradii, Hudsonia ericoides and Amelanchier lucida. The need to protect representative examples is supported

Animal Agriculture in South Carolina: A Fact Book

Livestock Production/Industries,

Applications of Trajectory Data From the Perspective of a Road Transportation Agency: Literature Review and Maryland Case Study

Transportation agencies have an opportunity to leverage increasingly-available trajectory datasets to improve their analyses and decision-making processes. However, this data is typically purchased from vendors, which means agencies must understand its potential benefits beforehand in order to properly assess its value relative to the cost of acquisition. While the literature concerned with trajectory data is rich, it is naturally fragmented and focused on technical contributions in niche areas, which makes it difficult for government agencies to assess its value across different transportation domains. To overcome this issue, the current paper explores trajectory data from the perspective of a road transportation agency interested in acquiring trajectories to enhance its analyses. The paper provides a literature review illustrating applications of trajectory data in six areas of road transportation systems analysis: demand estimation, modeling human behavior, designing public transit, traffic performance measurement and prediction, environment and safety. In addition, it visually explores 20 million GPS traces in Maryland, illustrating existing and suggesting new applications of trajectory data