Encoding and Analyzing the Timbre in Popular Songs (TiPS) Corpus

Timbre and texture are important and perceptually salient stylistic and structural parameters in popular music, yet their specific functional roles in this repertoire have not been theorized. This report describes the construction and encoding of a new popular-music corpus, Timbre in Popular Song (TiPS). The corpus comprises 400 songs, including 100 songs each from four disparate genres: country, pop, heavy metal, and hip hop. Song selection in TiPS balances genre typicality with considerations of gender and racial diversity as well as chronological representation; details related to timbre, texture, and form for each song are being encoded and will be analyzed by genre to identify normative timbral and textural combinations, as well as typical differences among genres

Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties

The biological activity of nanoparticle-directed therapies critically depends on cellular targeting. We examined the subtumoral fate of Particle Replication in Non-Wetting Templates (PRINT) nanoparticles in a xenografted melanoma tumor model by multi-color flow cytometry and in vivo confocal tumor imaging. These approaches were compared with the typical method of whole-organ quantification by radiolabeling. In contrast to radioactivity based detection which demonstrated a linear dose-dependent accumulation in the organ, flow cytometry revealed that particle association with cancer cells became dose-independent with increased particle doses and that the majority of the nanoparticles in the tumor were associated with cancer cells despite a low fractional association. In vivo imaging demonstrated an inverse relationship between tumor cell association and other immune cells, likely macrophages. Finally, variation in particle size nonuniformly affected subtumoral association. This study demonstrates the importance of subtumoral targeting when assessing nanoparticle activity within tumors