Jules Horowitz Reactor Operation Plan 2040 – JHOP2040

JHOP2040 project will deliver a European level strategy addressing resourcing, financing and organisational factors for the most effective way of utilising the Euratom access rights to the forthcoming Jules Horowitz Material Test Reactor (JHR). JHOP2040 is being carried out by a consortium gathering ten partners representing the European partners involved in building the JHR. The project includes an International Scientific Advisory Group and Support Group consisting of external experts in research facility operations, non-European JHR consortium members as well as representatives from Euratom members states, which are not partners in the JHR consortium

An overview of non-centralized Kalman filters

The usage of wireless sensor networks (WSNs) for state-estimation has recently gained increasing attention due to its cost effectiveness and feasibility. One of the major challenges of state-estimation via WSNs is the distribution of the centralized state-estimator among the nodes in the network. Significant emphasis has been on developing non-centralized state-estimators considering communication, processing-demand and estimation-error. This survey paper presents different methodologies to obtain non-centralized state-estimators and focuses on the estimation algorithms and their implementation. The temperature distribution of a bar is used as a benchmark to assess the non-centralized state-estimators in terms of estimation-error and communication requirements

The High Tech, Human Touch Magazine:2014 Edition

For the course Technolab in the master program Philosophy of Science, Technology, and Society, supervised by prof.dr.ir. M. Boon, we were assigned to write a magazine that covers three different research projects within the University of Twente. In the magazine, we examined the technological, social, and philosophical aspects of the research projects. Going through the magazine, we will take you along different technologies from outside the human body until cellular level. We can enhance the human body, enhance the way to detect illnesses in the human body, and enhance the human lifestyle. Do we really want to enhance the human being in all thinkable ways, or only enhance some aspects

Chromosomal copy number heterogeneity predicts survival rates across cancers.

Survival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain these distinct disease outcomes. In contrast, intra-tumour heterogeneity (ITH) has the potential to elucidate pan-cancer survival rates and the biology that drives cancer prognosis. Unfortunately, a comprehensive and effective framework to measure ITH across cancers is missing. Here, we introduce a scalable measure of chromosomal copy number heterogeneity (CNH) that predicts patient survival across cancers. We show that the level of ITH can be derived from a single-sample copy number profile. Using gene-expression data and live cell imaging we demonstrate that ongoing chromosomal instability underlies the observed heterogeneity. Analysing 11,534 primary cancer samples from 37 different malignancies, we find that copy number heterogeneity can be accurately deduced and predicts cancer survival across tissues of origin and stages of disease. Our results provide a unifying molecular explanation for the different survival rates observed between cancer types