500 research outputs found
Low-speed impact craters in loose granular media
We report on craters formed by balls dropped into dry, non-cohesive, granular
media. By explicit variation of ball density , diameter , and
drop height , the crater diameter is confirmed to scale as the 1/4 power of
the energy of the ball at impact:
. Against expectation, a different
scaling law is discovered for the crater depth:
. The scaling with properties of
the medium is also established. The crater depth has significance for granular
mechanics in that it relates to the stopping force on the ball.Comment: experiment; 4 pages, 3 figure
Clinical characterization of 66 patients with congenital retinal disease due to the deep-intronic c.2991+1655A>G mutation in CEP290
Purpose: To describe the phenotypic spectrum of retinal disease caused by the c.2991+1655A>G mutation in CEP290 and to compare disease severity between homozygous and compound heterozygous patients.
Methods: Medical records were reviewed for best-corrected visual acuity (BCVA), age of onset, fundoscopy descriptions. Foveal outer nuclear layer (ONL) and ellipsoid zone (EZ) presence was assessed using spectral-domain optical coherence tomography (SD-OCT). Differences between compound heterozygous and homozygous patients were analyzed based on visual performance and visual development.
Results: A total of 66 patients were included. The majority of patients had either light perception or no light perception. In the remaining group of 14 patients, median BCVA was 20/195 Snellen (0.99 LogMAR; range 0.12-1.90) for the right eye, and 20/148 Snellen (0.87 LogMAR; range 0.22-1.90) for the left. Homozygous patients tended to be more likely to develop light perception compared to more severely affected compound heterozygous patients (P = 0.080) and are more likely to improve from no light perception to light perception (P = 0.022) before the age of 6 years. OCT data were available in 12 patients, 11 of whom had retained foveal ONL and EZ integrity up to 48 years (median 23 years) of age.
Conclusions: Homozygous patients seem less severely affected compared to their compound-heterozygous peers. Improvement of visual function may occur in the early years of life, suggesting a time window for therapeutic intervention up to the approximate age of 17 years. This period may be extended by an intact foveal ONL and EZ on OCT
The (co-)occurrence of problematic video gaming, substance use, and psychosocial problems in adolescents
Aims. The current study explored the nature of problematic (addictive) video gaming and the association with game type, psychosocial health, and substance use. Methods. Data were collected using a paper and pencil survey in the classroom setting. Three samples were aggregated to achieve a total sample of 8478 unique adolescents. Scales included measures of game use, game type, the Video game Addiction Test (VAT), depressive mood, negative self-esteem, loneliness, social anxiety, education performance, and use of cannabis, alcohol and nicotine (smoking). Results. Findings confirmed problematic gaming is most common amongst adolescent gamers who play multiplayer online games. Boys (60%) were more likely to play online games than girls (14%) and problematic gamers were more likely to be boys (5%) than girls (1%). High problematic gamers showed higher scores on depressive mood, loneliness, social anxiety, negative self-esteem, and self-reported lower school performance. Nicotine, alcohol, and cannabis using boys were almost twice more likely to report high PVG than non-users. Conclusions. It appears that online gaming in general is not necessarily associated with problems. However, problematic gamers do seem to play online games more often, and a small subgroup of gamers – specifically boys – showed lower psychosocial functioning and lower grades. Moreover, associations with alcohol, nicotine, and cannabis use are found. It would appear that problematic gaming is an undesirable problem for a small subgroup of gamers. The findings encourage further exploration of the role of psychoactive substance use in problematic gaming
Promises and Pitfalls of Social Media Data Donations
Studies assessing the effects of social media use are largely based on measures of time spent on social media. In recent years, scholars increasingly ask for more insights in social media activities and content people engage with. Data Download Packages (DDPs), the archives of social media platforms that each European user has the right to download, provide a new and promising method to collect timestamped and content-based information about social media use. In this paper, we first detail the experiences and insights of a data collection of 110 Instagram DDPs gathered from 102 adolescents. We successively discuss the challenges and opportunities of collecting and analyzing DDPs to help future researchers in their consideration of whether and how to use DDPs. DDPs provide tremendous opportunities to get insight in the frequency, range, and content of social media activities, from browsing to searching and posting. Yet, collecting, processing, and analyzing DDPs is also complex and laborious, and demands numerous procedural and analytical choices and decisions
Trends in treatment and overall survival among patients with proximal esophageal cancer
BACKGROUND:
The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures. Non-surgical treatment options like radiotherapy and definitive chemoradiation (CRT) have been implemented. The trends in (non-)surgical treatment and its impact on overall survival (OS) in patients with proximal esophageal cancer are unclear, related to its rare disease status. To optimize treatment strategies and counseling of patients with proximal esophageal cancer, it is therefore essential to gain more insight through real-life studies.
AIM:
To establish trends in treatment and OS in patients with proximal esophageal cancer.
METHODS:
In this population-based study, patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry. The proximal esophagus consists of the cervical esophagus and the upper thoracic section, extending to 24 cm from the incisors. Trends in radiotherapy, chemotherapy, and surgery, and OS were assessed. Analyses were stratified by presence of distant metastasis. Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS, adjusted for patient, tumor, and treatment characteristics.
RESULTS:
In total, 2783 patients were included. Over the study period, the use of radiotherapy, resection, and CRT in non-metastatic disease changed from 53%, 23%, and 1% in 1989-1994 to 21%, 9%, and 49% in 2010-2014, respectively. In metastatic disease, the use of chemotherapy and radiotherapy increased over time. Median OS of the total population increased from 7.3 mo [95% confidence interval (CI): 6.4-8.1] in 1989-1994 to 9.5 mo (95%CI: 8.1-10.8) in 2010-2014 (logrank P < 0.001). In non-metastatic disease, 5-year OS rates improved from 5% (95%CI: 3%-7%) in 1989-1994 to 13% (95%CI: 9%-17%) in 2010-2014 (logrank P < 0.001). Multivariable regression analysis demonstrated a significant treatment effect over time on survival. In metastatic disease, median OS was 3.8 mo (95%CI: 2.5-5.1) in 1989-1994, and 5.1 mo (95%CI: 4.3-5.9) in 2010-2014 (logrank P = 0.26).
CONCLUSION:
OS significantly improved in non-metastatic proximal esophageal cancer, likely to be associated with an increased use of CRT. Patterns in metastatic disease did not change significantly over time
Average luminosity distance in inhomogeneous universes
The paper studies the correction to the distance modulus induced by
inhomogeneities and averaged over all directions from a given observer. The
inhomogeneities are modeled as mass-compensated voids in random or regular
lattices within Swiss-cheese universes. Void radii below 300 Mpc are
considered, which are supported by current redshift surveys and limited by the
recently observed imprint such voids leave on CMB. The averaging over all
directions, performed by numerical ray tracing, is non-perturbative and
includes the supernovas inside the voids. Voids aligning along a certain
direction produce a cumulative gravitational lensing correction that increases
with their number. Such corrections are destroyed by the averaging over all
directions, even in non-randomized simple cubic void lattices. At low
redshifts, the average correction is not zero but decays with the peculiar
velocities and redshift. Its upper bound is provided by the maximal average
correction which assumes no random cancelations between different voids. It is
described well by a linear perturbation formula and, for the voids considered,
is 20% of the correction corresponding to the maximal peculiar velocity. The
average correction calculated in random and simple cubic void lattices is
severely damped below the predicted maximal one after a single void diameter.
That is traced to cancellations between the corrections from the fronts and
backs of different voids. All that implies that voids cannot imitate the effect
of dark energy unless they have radii and peculiar velocities much larger than
the currently observed. The results obtained allow one to readily predict the
redshift above which the direction-averaged fluctuation in the Hubble diagram
falls below a required precision and suggest a method to extract the background
Hubble constant from low redshift data without the need to correct for peculiar
velocities.Comment: 34 pages, 21 figures, matches the version accepted in JCA
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