Heavy-ion physics studies for the Future Circular Collider

The Future Circular Collider (FCC) design study is aimed at assessing the physics potential and the technical feasibility of a new collider with centre-of-mass energies, in the hadron-hadron collision mode including proton and nucleus beams, more than seven-times larger than the nominal LHC energies. An electron-positron collider in the same tunnel is also considered as an intermediate step, which would provide the electron-hadron option in the long term. First ideas on the physics opportunities with heavy ions at the FCC are presented, covering the physics of Quark-Gluon Plasma, gluon saturation, photon-induced collisions, as well as connections with ultra-high-energy cosmic rays.Comment: 4 pages, 3 figures, proceedings of Quark Matter 2014, Darmstadt, Germany, submitted to Nucl. Phys.

Nuclear collisions at the Future Circular Collider

The Future Circular Collider is a new proposed collider at CERN with centre-of-mass energies around 100 TeV in the pp mode. Ongoing studies aim at assessing its physics potential and technical feasibility. Here we focus on updates in physics opportunities accessible in pA and AA collisions not covered in previous Quark Matter contributions, including Quark-Gluon Plasma and gluon saturation studies, novel hard probes of QCD matter, and photon-induced collisions.Comment: 4 pages, 5 figures, proceedings of Quark Matter 201

Mid- and late-Holocene vegetation and fire history at Biviere di Gela, a coastal lake in southern Sicily, Italy

The vegetation and fire history of few coastal sites has been investigated in the Mediterranean region so far. We present the first paleoecological reconstruction from coastal Sicily, the largest island in the Mediterranean Sea. We analysed pollen and charcoal in the sediments of Biviere di Gela, a lake (lagoon) on the south coast of Sicily. Our data suggest that the area became afforested after a marine transgression at ca. 7200 cal b.p. (5250 b.c.). Build-up of forest and shrublands took ca. 200-300years, mainly with the deciduous trees Quercus, Ostrya and Fraxinus. Juniperus expanded ca. 6900 cal b.p. (4950 b.c.), but declined again 6600 cal b.p. (4650 b.c.). Afterwards, evergreen trees (Q. ilex-type and Olea) became dominant in the forest and Pistacia shrublands were established. Forest and shrubland reached a maximum ca. 7000-5000 cal b.p. (5050-3050 b.c.); subsequently forest declined in response to human impact, which was probably exacerbated by a general trend towards a more arid climate. During the Neolithic, fire was used to open the landscape, significantly reducing several arboreal taxa (Q. ilex, Fraxinus, Juniperus) and promoting herbs and shrubs (Achillea, Cichorioideae, Brassicaceae, Ephedra). Final forest disruption occurred around 2600 cal b.p. (650 b.c.) with the onset of the historically documented Greek colonization. We conclude that the open maquis and garrigue vegetation of today is primarily the consequence of intensive land-use over millennia. Under natural or near-natural conditions arboreal taxa such as Q. ilex, Olea and Pistacia would be far more important than they are today, even under the hot and rather dry coastal conditions of southern Sicil

Producción

Fascículo que describe el concepto de producción, se exponen las características y objetivos específicos de la producción en la pequeña empresa asociativa, sistemas para preparación, programación y organización de la producción y métodos para el cálculo de costos de producción.Fascicle describing the concept of production, the specific characteristics and objectives of production in the small associative enterprise, systems for preparation, programming and organization of production and methods for calculating production costs are set out.Características y objetivos de la pequeña empresa -- Preparación, programación y organización de la producción en empresas urbanas -- Preparacion programacion y organizacion de la producción en empresas agropecuarias -- Calculo de costos de producción en empresas urbanas -- Cálculo de costos de producción en empresas ruralesna75 página

Mercadeo

Se describen conceptos asociados al mercadeo y se presenta el material de referencia que corresponde al área de mercadeo de la empresa asociativa en todas sus facetas y durante todas sus fases de desarrollo.Concepts associated with marketing are described and the reference material corresponding to the marketing area of the associative company in all its facets and during all its development phases is presented.El concepto de mercadeo -- Definición del mercado para la empresa asociativa -- Estrategia del mercado para la empresa asociativa -- El producto -- El precio -- La distribución -- La promociónnaDocumento producto del convenio de cooperación técnica SENA - Holanda.Series de la colección PMUR: 1. Guía Metodológica; 2. Material Didáctico; 3. Lecturas de Referencia; 4. Estudios.Publicaciones de la serie “Lecturas de referencia” : 1. Características de las Empresas Asociativas; 2. Mercadeo; 3. Producción; 4. Tecnología; 5. Financiación; 6. Contabilidad; 7. Marco Legal; 8. Formación Socioempresarial.92 página

Thoughts on opportunities in high-energy nuclear collisions

This document reflects thoughts on opportunities from high-energy nuclear collisions in the 2020s.Comment: 10 pages, pd

Financiación

Fascículo de la serie “Lecturas de referencia” que describe cómo tratar los problemas financieros en las empresas asociativas, sistema financiero adecuado en la empresa asociativa y principios para el manejo del área financiera.Fascicle of the series “Reference readings” that describes how to deal with financial problems in associative companies, adequate financial system in the associative company and principles for managing the financial area.La problemática de la financiación de empresas asociativas en los niveles informales -- una visión estructural del problema -- sistema financiero adecuado - el fondo de apoyo de empresas asociativas -- el manejo del área financiera al interior de las empresasnaDocumento producto del convenio de cooperación técnica SENA - Holanda.Series de la colección PMUR: 1. Guía Metodológica; 2. Material Didáctico; 3. Lecturas de Referencia; 4. Estudios.Publicaciones de la serie “Lecturas de referencia” : 1. Características de las Empresas Asociativas; 2. Mercadeo; 3. Producción; 4. Tecnología; 5. Financiación; 6. Contabilidad; 7. Marco Legal; 8. Formación Socioempresarial.40 página

Beliefs, barriers and preferences of European overweight women to adopt a healthier lifestyle in pregnancy to minimize risk of developing gestational diabetes mellitus: an explorative study

Introduction: Overweight and obese women are at high risk of developing gestational diabetes mellitus (GDM). Lifestyle programs might help curb the GDM risk. We explored beliefs, perceived barriers and preferences regarding lifestyle changes among overweight European pregnant women to help inform the development of future high quality lifestyle interventions. Methods: An explorative mixed methods, two-staged study was conducted to gather information from pregnant European women (BMI≥25kg/m2). In three European countries (Belgium, Netherlands, United Kingdom) interviews were conducted, followed by questionnaires in six other European countries (Austria, Denmark, Ireland, Italy, Poland, Spain). Content analysis, descriptive and chi square statistics were applied (p<0.05). Results: Women preferred to obtain detailed information about their personal risk. The health of their baby was major motivating factor. Perceived barriers for physical activity included pregnancy-specific issues such as tiredness and experiencing physical complaints. Insufficient time was a barrier more frequently reported by women with children. Abstaining from snacking was identified as a challenge for the majority of women, especially for those without children. Women preferred to obtain support from their partner, as well as health professionals and valued flexible lifestyle programs. Conclusions: Healthcare professionals need to inform overweight pregnant women about their personal risk, discuss lifestyle modification and assist in weight management. Lifestyle programs should be tailored to the individual, taking into account barriers experienced by overweight first-time mothers and multipara women

Sensitizing thermochemotherapy with a PARP1-inhibitor

Cis-diamminedichloroplatinum(II) (cisplatin, cDDP) is an effective chemotherapeutic agent that induces DNA double strand breaks (DSBs), primarily in replicating cells. Generally, such DSBs can be repaired by the classical or backup non-homologous end joining (c-NHEJ/b-NHEJ) or homologous recombination (HR). Therefore, inhibiting these pathways in cancer cells should enhance the efficiency of cDDP treatments. Indeed, inhibition of HR by hyperthermia (HT) sensitizes cancer cells to cDDP and in the Netherlands this combination is a standard treatment option for recurrent cervical cancer after previous radiotherapy. Additionally, cDDP has been demonstrated to disrupt c-NHEJ, which likely further increases the treatment efficacy. However, if one of these pathways is blocked, DSB repair functions can be sustained by the Poly-(ADP-ribose)-polymerase1 (PARP1)-dependent b-NHEJ. Therefore, disabling b-NHEJ should, in principle, further inhibit the repair of cDDP-induced DNA lesions and enhance the toxicity of thermochemotherapy. To explore this hypothesis, we treated a panel of cancer cell lines with HT, cDDP and a PARP1-i and measured various end-point relevant in cancer treatment. Our results demonstrate that PARP1-i does not considerably increase the efficacy of HT combined with standard, commonly used cDDP concentrations. However, in the presence of a PARP1-i, ten-fold lower concentration of cDDP can be used to induce similar cytotoxic effects. PARP1 inhibition may thus permit a substantial lowering of cDDP concentrations without diminishing treatment efficacy, potentially reducing systemic side effects

Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia

Background: Poly-(ADP-ribose)-polymerase1 (PARP1) is involved in repair of DNA single strand breaks. PARP1-inhibitors (PARP1-i) cause an accumulation of DNA double strand breaks, which are generally repaired by homologous recombination (HR). Therefore, cancer cells harboring HR deficiencies are exceptionally sensitive to PARP1-i. For patients with HR-proficient tumors, HR can be temporarily inhibited by hyperthermia, thereby inducing synthetic lethal conditions in every tumor type. Since cisplatin is successfully used combined with hyperthermia (thermochemotherapy), we investigated the effectiveness of combining PARP1-i with thermochemotherapy. Results: The in vitro data demonstrate a decreased in cell survival after addition of PARP1-i to thermochemotherapy, which can be explained by increased DNA damage induction and less DSB repair. These in vitro findings are in line with in vivo model, in which a decreased tumor growth is observed upon addition of PARP1-i. Materials and Methods: Survival of three HR-proficient cell lines after cisplatin, hyperthermia and/or PARP1-i was studied. Cell cycle analyses, quantification of γ-H2AX foci and apoptotic assays were performed to understand these survival data. The effects of treatments were further evaluated by monitoring tumor responses in an in vivo rat model. Conclusions: Our results in HR-proficient cell lines suggest that PARP1-i combined with thermochemotherapy can be a promising clinical approach for all tumors independent of HR status