Neighborhood stigma and the sporting lives of young people in public housing

This paper spotlights the sporting lives of young people who live in ‘Redcrest’, a public housing community in the Niagara region of Canada. We report on data culled from neighborhoodcentric documents (municipal data, planning council reports, media coverage) and ethnographic fieldwork (interviews, community mapping, go-alongs) collected over eight months with 14 young people. This paper also offers a critique of Robert Sampson’s work on neighborhood effects and draws on the theoretical insights and urban scholarship of Henri Lefebvre, Loic Wacquant, and the work of postcolonial scholar Frantz Fanon, who further understandings of racism as a spatial relation. At the center of this research are narratives that highlight that public housing projects, negative stigma notwithstanding, can be good places to live. The results highlight the various contradictions and tensions experienced by young people living in Redcrest, specifically their experiences with neighborhood stigma, racism and Islamophobia, and how this impacts their sporting lives

The Health-e-Waterways Project: Data Integration for Smarter Collaborative Whole-of-Water Cycle Management

The Health-e-Waterways Project is a collaboration between the University of Queensland, Microsoft Research and the South East Queensland Healthy Waterways Partnership (SEQ-HWP) (a consortium of over 60 local government, state agency, universities, community and environmental organizations). The aim of the project is to develop a highly innovative framework and set of services to enable streamlined access to a collection of real-time, near-real-time and static datasets acquired through ecosystem health monitoring programs (EHMP) in South East Queensland. This paper describes the underlying water information management system and Web Portal that we are developing to enable the sharing and integration of the high quality data and models for SEQ water resource managers. In addition we will describe the interactive and dynamic ecosystem reporting services that we have developed and the WaterWiki that is being established to enable knowledge exchange between the online community of Queensland’s water stakeholders

Зміна роздільної здатності зображень на основі власних векторів матриць-операторів індукованих з піксельних наборів

The method of problem solving increase resolution image sets provided that the dimension of the set. The method is to build a matrix operator and find its eigenvectors. Using sets of eigenvectors and matrix color images developed a practical set of algorithm changes the resolution

A Good Place for What? Placing ‘Value’ in Youth Centres

In this paper, we investigate the discursive context of community-based youth centres to critically interrogate ideas and practices concerning leisure, youth, and youth centres. Using publicly available documents and data collected with youth at two community-based youth centres, we ask, what is the “good”’ that they do for young people, and how do young people negotiate these discourses? We argue that the youth centres operate in a discursive tension, constructed as a place to change by the (organizational) bodies that established them, and a place to chill by the (youth) bodies that used them. We trace how these discourses entered into the everyday lived contexts of youth centres including their program logics, measures of success, and constructions of youthful subjectivities. We close with a discussion of the implications of the research in terms of how youth and recreation practitioners might use youth centres to support young people’s leisure

Recognition of Nucleosomes by Chromatin Factors: Lessons from Data-Driven Docking-Based Structures of Nucleosome-Protein Complexes

The function of chromatin ultimately depends on the many chromatin-associated proteins and protein complexes that regulate all DNA-templated processes such as transcription, repair and replication. As the molecular docking platform for these proteins, the nucleosome is the essential gatekeeper to the genome. As such, the nucleosome-binding activity of a myriad of proteins is essential for a healthy cell. Here, we review the molecular basis of nucleosome-protein interactions and classify the different binding modes available. The structural data needed for such studies not only come from traditional sources such as X-Ray crystallography but also increasingly from other sources. In particular, we highlight how partial interaction data, derived from for example NMR or mutagenesis, are used in data-driven docking to drive the modeling of the complex into an atomistic structure. This approach has opened up detailed insights for several nucleosome-protein complexes that were intractable or recalcitrant to traditional methods. These structures guide the formation of new hypotheses and advance our understanding of chromatin function at the molecular level

Non-tuberculous mycobacteria in sputum cultures in Suriname

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Dissemination of Mycobacterium abscessus via global transmission networks.

Mycobacterium abscessus, a multidrug-resistant nontuberculous mycobacterium, has emerged as a major pathogen affecting people with cystic fibrosis (CF). Although originally thought to be acquired independently from the environment, most individuals are infected with one of several dominant circulating clones (DCCs), indicating the presence of global transmission networks of M. abscessus. How and when these clones emerged and spread globally is unclear. Here, we use evolutionary analyses of isolates from individuals both with and without CF to reconstruct the population history, spatiotemporal spread and recent transmission networks of the DCCs. We demonstrate synchronous expansion of six unrelated DCCs in the 1960s, a period associated with major changes in CF care and survival. Each of these clones has spread globally as a result of rare intercontinental transmission events. We show that the DCCs, but not environmentally acquired isolates, exhibit a specific smoking-associated mutational signature and that current transmission networks include individuals both with and without CF. We therefore propose that the DCCs initially emerged in non-CF populations but were then amplified and spread through the CF community. While individuals with CF are probably the most permissive host, non-CF individuals continue to play a key role in transmission networks and may facilitate long-distance transmission.Funding for this work was provided by The Wellcome Trust (investigator award no. 107032/Z/15/Z to R.A.F.), Fondation Botnar (Programme grant no. 6063) and the UK CF Trust (Innovation Hub award no. 001; Strategic Research Centre award no. 010). M.S., N.A.H. and R.M.D. acknowledge the Cystic Fibrosis Foundation for funding

Dutch multidisciplinary guideline on Achilles tendinopathy

Objective To provide a comprehensive, evidence-based overview of the risk factors, prevention, diagnosis, imaging, treatment and prognosis for Achilles tendinopathy. To make clinical recommendations for healthcare practitioners and patients. Design Comprehensive multidisciplinary guideline process funded by the Quality Foundation of the Dutch Federation of Medical Specialists. This process included a development, commentary and authorisation phase. Patients participated in every phase. Data sources Multiple databases and existing guidelines were searched up to May 2019. Information from patients, healthcare providers and other stakeholders were obtained using a digital questionnaire, focus group interview and invitational conference. Study eligibility criteria Studies on both insertional and/or midportion Achilles tendinopathy were eligible. Specific eligibility criteria were described per module. Data extraction and synthesis To appraise the certainty of evidence, reviewers extracted data, assessed risk of bias and used the Grading of Recommendations Assessment, Development and Evaluation method, where applicable. Important considerations were: patient values and preferences, costs, acceptability of other stakeholders and feasibility of implementation. Recommendations were made based on the results of the evidence from the literature and the considerations. Primary outcome measure The primary and secondary outcome measures were defined per module and defined based on the input of patients obtained in collaboration with the Netherlands Patient Federation and healthcare providers from different professions. Results Six specific modules were completed: risk factors and primary prevention, diagnosis, imaging, treatment prognosis and secondary prevention for Achilles tendinopathy. Summary/conclusion Our Dutch multidisciplinary guideline on Achilles tendinopathy provides six modules developed according to the standards of the Dutch Federation of Medical Specialists. Evidence-based recommendations for clinical practice are given for risk factors, prevention, diagnosis, imaging, treatment and prognosis. This guideline can assist healthcare providers and patients in clinical practice

Is every female equal? Caste biasing in tropical paper wasps

Item does not contain fulltextDiseases caused by nontuberculous mycobacteria are emerging in many settings. With an increased number of patients needing treatment, the role of drug susceptibility testing is again in the spotlight. This articles covers the history and methodology of drug susceptibility tests for nontuberculous mycobacteria, but focuses on the correlations between in vitro drug susceptibility, pharmacokinetics and in vivo outcomes of treatment. Among slow-growing nontuberculous mycobacteria, clear correlations have been established for macrolides and amikacin (Mycobacterium avium complex) and for rifampicin (Mycobacterium kansasii). Among rapid-growing mycobacteria, correlations have been established in extrapulmonary disease for aminoglycosides, cefoxitin and co-trimoxazole. In pulmonary disease, correlations are less clear and outcomes of treatment are generally poor, especially for Mycobacterium abscessus. The clinical significance of inducible resistance to macrolides among rapid growers is an important topic. The true role of drug susceptibility testing for nontuberculous mycobacteria still needs to be addressed, preferably within clinical trials