Correlating magnetic fabrics with finite strain : comparing results from mudrocks in the Variscan and Appalachian Orogens

New magnetic anisotropy data from Variscan mudstones collected in the Cantabrian Arc, N Spain constrain the corresponding strain (shortening). The results are based on our previous study of mudrocks from the Valley and Ridge Province (Appalachians) where independent strain quantification of pencil structures permitted a correlation between magnetic fabric and tectonic strain. An exponential relationship between the AMS shape parameter T and tectonic shortening was found for the interval of 10-25% shortening: shortening (%)=17*exp(T), relationship that appears to be supported by tectonic strains up to 40%. The T parameter describes the shape of the magnetic susceptibility ellipsoid, which in pelitic rocks appears more sensitive to strain than the degree of anisotropy parameter P (or P'). In mudrocks from the Cantabrian Arc a positive correlation between T parameter and deformation intensity, reflected by cleavage domains spacing, is observed. Using the above relationship, we estimate the range of tectonic shortening for the Cantabrian mudstones. The correlation between strain and AMS offers a robust estimate of strain magnitude of 10-40% in weakly to moderately deformed clay-rich rocks, where other strain indicators are often lacking or are poorly preserved

TEM and AEM constraints on the origin and significance of chlorite-mica stacks in slates: an example from Central Wales, U.K.

Chlorite-mica stacks (grains of intergrown chlorite and white mica) in a matrix of fine-grained white mica and chlorite have been studied using XRD, SEM, EMPA, TEM and AEM methods. The stacks occur in a weakly cleaved Llandoverian mudstone, central Wales, which has a white mica (illite) crystallinity index of 0.35[deg] [Delta]2[phi] corresponding to the lower anchizone. White mica occurs as packets (100 A to 8 [mu]m thick) interleaved with dominant chlorite packets in stacks, with both apparent coherent interfaces or cross-cutting small angle boundaries with chlorite layers. It is well-crystallized 2M1 polytype with phengitic composition and low paragonite component [Na/(Na + K) 2 crystals surround stacks and occur within chlorite, and white mica is Ti-rich compared to matrix white mica.Fine-grained white mica and chlorite in the matrix have two different orientations: one parallel to hedding and one parallel to cleavage, which is approximately 30-50[deg] to bedding. Matrix white mica is predominantly a 2M1 polytype, but some cleavage-parallel white mica is 3T and some bedding-parallel white mica is 1Ma. It is Na-rich [(Na/(Na + K) ~ 0.14-0.42] and relatively heterogeneous; some discrete paragonite and phengitic muscovite are observed to coexist in the cleavage orientation. Matrix white mica and chlorite each contain less Fe than corresponding white mica and chlorite in stacks. Both matrix and stack chlorite are one-layer polytypes.The data imply that chlorite in the stacks is largely derived from the replacement of volcanogenic biotite and other ferromagnesian minerals (probably via intermediate expandable trioctahedral phyllosilicates). Most intergrowths of chlorite and mica in stacks formed by mica replacement of chlorite and altered biotite along cleavage fissures. Subsequent deformation caused further modification of pre-existing chlorite-mica stacks whereas partial dissolution of stacks and bedding-parallel matrix phyllosilicates resulted in the formation of cleavage-parallel phyllosilicates.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31427/1/0000345.pd

Note on analysis of quartz grain dimensions in foliated greywackes

Quarzkorn-Abmessungen aus Grauwacken wurden auf ein internes Referenzsystem (reference aspect ratio, RAR) bezogen und mit Hilfe der linearen Regressionsanalyse der reduzierten Hauptachse (reduced major axis, RMA) ausgewertet. Das verwendete statistische Verfahren unterscheidet im Gegensatz zur Methode der kleinsten Quadrate nicht zwischen abhängigen und unabhängigen Variablen. Die Anwendung der RMX-Methode in Verbindung mit den RAR-Meßwerten kann sehr hilfreich für Vergleiche innerhalb geschieferter Grauwacken sein, bei denen unterschiedliche Prozesse in Korngrößenbereich wirksam waren wie etwa Drucklösung und Festkörper-Rotation. Die RAR/RMA-Analyse erfaßt Kornregelungen und ist daher auch einsetzbar für die Klassifikation von Schieferungen. Darüber hinaus wird die Anwendung der RAR/RMA-Analyse für die Bestimmung der Deformation diskutiert. Robin strain-Werte werden mit arithmetischen und harmonischen Mittelwerten der RAR-Analyse verglichen. Es zeigt sich, daß das arithmetische Mittel des RAR ein vernünftiges Maß für die longitudinale Deformation darstellt. Quartz grain dimensions, measured parallel to an internal reference system (reference aspect ratio, RAR), were analyzed using the »reduced major axis« (RMA) linear regression analysis. In contrast to least-squares analysis, this statistical technique does not distinguish between dependent and independent variables. Application of the RMA analysis in conjunction with RAR values can be most useful for comparisons between foliated greywackes in which different grain scale processes, such as pressure solution and rigid-body rotation, were active. The RAR/RMA analysis reflects grain alignment and is therefore also useful for cleavage classification. In addition to the above, the application of RAR/RMA analysis for the determination of strain is discussed. Robin strains are compared with the arithmetic and harmonic means from RAR's and it is concluded that the arithmetic mean RAR produces a reasonable estimate of longitudinal strain in these rocks. Les dimensions des grains de quartz, mesurés parallèlement à un système de référence interne (»reference aspect ratio«: RAR) ont été traitées par la méthode de la régression linéaire (»reduced major axis«: RMA). Contrairement à la méthode des moindres carrés, cette technique statistique ne fait pas de distinction entre les variables dépendantes et indépendantes. L'application de ce type de méthode s'avère très utile à la comparaison de grauwackes schisteuses dans lesquelles les dimensions des grains peuvent être la conséquence de processus différents, tels que la dissolution (pressure solution) et la rotation. L'analyse RAR/RMA traduit l'alignement des grains et peut, de ce fait, être utilisée aussi à l'appréciation du type de schistosité. D'autre part, l'auteur discute l'application de l'analyse RAR/RMA à la détermination de la déformation finie. Si on compare les déformations »Robin« aux moyennes arithmétique et harmonique des RAR, on peut conclure que les moyennes RAR arithmétiques fournissent une estimation raisonnable de la déformation longitudinale. Помимо интернациона льной системы RAR, разме ры зерен кварца анализи ровали с помощью регр ессивного анализа «Изменение о сновных осей» — RMA. В отличие от анализа ме тодом наименьшего кв адратов, при названном статис тическом методе разл ичия между зависимыми и не зависимыми переменн ыми не учитываются. Компл ексное применение RAR иPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47848/1/531_2005_Article_BF01821068.pd

TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

SummaryPARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a robust physical interaction between PARP1 and the replication fork protein TIMELESS, distinct from the known TIMELESS-TIPIN complex, which activates the intra-S phase checkpoint. TIMELESS recruitment to laser-induced sites of DNA damage is dependent on its binding to PARP1, but not PARP1 activity. We also find that the PARP1-TIMELESS complex contains a number of established PARP1 substrates, and TIMELESS mutants unable to bind PARP1 are impaired in their ability to bind PARP1 substrates. Further, PARP1 binding to certain substrates and their recruitment to DNA damage lesions is impaired by TIMELESS knockdown, and TIMELESS silencing significantly impairs DNA double-strand break repair. We hypothesize that TIMELESS cooperates in the PARP1-mediated DDR

Treatments affecting splenic function as a risk factor for valvular heart disease in Childhood Cancer Survivors:A DCCSS-LATER study

PurposeSplenectomy might be a risk factor for valvular heart disease (VHD) in adult Hodgkin lymphoma survivors. As this risk is still unclear for childhood cancer survivors (CCS), the aim of this study is to evaluate the association between treatments affecting splenic function (splenectomy and radiotherapy involving the spleen) and VHD in CCS.MethodsCCS were enrolled from the DCCSS-LATER cohort, consisting of 6,165 five-year CCS diagnosed between 1963 and 2002. Symptomatic VHD, defined as symptoms combined with a diagnostic test indicating VHD, was assessed from questionnaires and validated using medical records. Differences in the cumulative incidence of VHD between CCS who received treatments affecting splenic function and CCS who did not were assessed using the Gray test. Risk factors were analyzed in a multivariable Cox proportional hazards model.ResultsThe study population consisted of 5,286 CCS, with a median follow-up of 22 years (5-50 years), of whom 59 (1.1%) had a splenectomy and 489 (9.2%) radiotherapy involving the spleen. VHD was present in 21 CCS (0.4%). The cumulative incidence of VHD at the age of 40 years was significantly higher in CCS who received treatments affecting splenic function (2.7%, 95% confidence interval (CI) 0.4%-4.9%) compared with CCS without (0.4%, 95% CI 0.1%-0.7%) (Gray's test, p = 0.003). Splenectomy was significantly associated with VHD in a multivariable analysis (hazard ratio 8.6, 95% CI 3.1-24.1).Conclusions and implicationsSplenectomy was associated with VHD. Future research is needed to determine if CCS who had a splenectomy as part of cancer treatment might benefit from screening for VHD