Mecanismo de cambio de contexto de tareas en una arquitectura PowerPC

El estudio se centra en la implementación de un mecanismo de cambio de contexto rápido de tareas en un Scheduler Preemptive para la arquitectura PowerPC, ya que se utiliza ampliamente en el área automotriz, desde pequeños de control de un actuador o monitoreo de un sensor hasta el desarrollo de un módulo de gran procesamiento como lo es un BCM (Body Controller Module).Consejo Nacional de Ciencia y Tecnologí

Biorefinery of biomass of agro-Industrial banana waste to obtain high-value biopolymers

On a worldwide scale, food demand is increasing as a consequence of global population growth. This makes companies push their food supply chains’ limits with a consequent increase in generation of large amounts of untreated waste that are considered of no value to them. Biorefinery technologies offer a suitable alternative for obtaining high-value products by using unconventional raw materials, such as agro-industrial waste. Currently, most biorefineries aim to take advantage of specific residues (by either chemical, biotechnological, or physical treatments) provided by agro-industry in order to develop high-value products for either in-house use or for sale purposes. This article reviews the currently explored possibilities to apply biorefinery-known processes to banana agro-industrial waste in order to generate high-value products out of this residual biomass source. Firstly, the Central and Latin American context regarding biomass and banana residues is presented, followed by advantages of using banana residues as raw materials for the production of distinct biofuels, nanocellulose fibers, different bioplastics, and other high-value products Lastly, additional uses of banana biomass residues are presented, including energy generation and water treatmen

Fecal microbiota transplantation in HIV: A pilot placebo-controlled study

Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio < 1 randomized to either weekly fecal microbiota capsules or placebo for 8 weeks. Stool donors were rationally selected based on their microbiota signatures. We report that fecal microbiota transplantation (FMT) is safe, not related to severe adverse events, and attenuates HIV-associated dysbiosis. FMT elicits changes in gut microbiota structure, including significant increases in alpha diversity, and a mild and transient engraftment of donor’s microbiota during the treatment period. The greater engraftment seems to be achieved by recent antibiotic use before FMT. The Lachnospiraceae and Ruminococcaceae families, which are typically depleted in people with HIV, are the taxa more robustly engrafted across time-points. In exploratory analyses, we describe a significant amelioration in the FMT group in intestinal fatty acid-binding protein (IFABP), a biomarker of intestinal damage that independently predicts mortality. Gut microbiota manipulation using a non-invasive and safe strategy of FMT delivery is feasible and deserves further investigation. Trial number: NCT03008941.This work was supported by the Instituto de Salud Carlos III (Plan Estatal de I + D + i 2013–2016, project PI18/00154, a Gilead Fellowship (GLD16-00030), the SPANISH AIDS Research Network RD16/0025/0001project), and co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (ERDF). The present investigation was also funded by the Instituto de Salud Carlos III and the Fundación Asociación Española contra el Cáncer within the ERANET TRANSCAN-2 program, grant number AC17/00022, a crowdfunding project from the precipita platform of the Fundación Española para la Ciencia y la Tecnología (FECYT) and a restricted grant from Finch Therapeutics. The SEIMC-GESIDA Foundation supported this study with safety and data monitoring (GESIDA 9116).Peer reviewe

International lower limb collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures

Trauma remains a major cause of mortality and disability across the world1, with a higher burden in developing nations2. Open lower extremity injuries are devastating events from a physical3, mental health4, and socioeconomic5 standpoint. The potential sequelae, including risk of chronic infection and amputation, can lead to delayed recovery and major disability6. This international study aimed to describe global disparities, timely intervention, guideline-directed care, and economic aspects of open lower limb injuries

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Galectin-9 Expression is Correlated to Cervical Squamous Cell Carcinoma Progression and Overall Survival

Victoriano Mendieta-Carmona,1,2 Guadalupe Delgado-López,2 Julio Reyes-Leyva,3 Claudia Teresita Gutiérrez-Quiroz,4 Víctor Javier Vazquez-Zamora,4 Denisse Alejandra Picazo-Mendoza,4 Alvaro José Montiel-Jarquín,4 Laura Patricia Martinez-Morales,5 Verónica Vallejo-Ruiz2 1Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico; Posgrado en Ciencias Biológicas, Universidad NacionalAutónoma de México (Posgrado en Ciencias Biológicas, Unidad de Posgrado, Edificio D, 1 Piso, Circuito de Posgrados, Ciudad Universitaria, Coyoacán, CDMX, C.P. 04510, México; 2Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Atlixco, Puebla, México; 3Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, México; 4Hospital de Especialidades, General Manuel Ávila Camacho, Instituto Mexicano Del Seguro Social, Puebla, México; 5CONAHCYT-CIBIOR, Atlixco, Puebla, MéxicoCorrespondence: Verónica Vallejo-Ruiz, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Federal Atlixco-Metepec, s/n, Atlixco, Puebla, Z.C. 74360, México, Tel +52 24 44 440 122, Email [email protected]; [email protected]: To determine whether galectin-9 gene (LGALS9) expression is correlated with cervical cancer progression, clinicopathological characteristics, and overall survival. To determine the biological processes and the abundance of tumour infiltrating immune cells related to the expression of LGALS9.Patients and Methods: The study was conducted in two phases: 1) The expression level of LGALS9 was determined using the data of 193 squamous cell carcinoma (SCC) samples from The Cancer Genome Atlas (TCGA) database. Biological processes and tumour infiltrating cells associated to LGALS9 expression were evaluated using gene set enrichment analysis (GSEA) and tumour immune estimation resource (TIMER). 2) Independently, galectin-9 was identified in 40 SCC samples by immunohistochemistry and optical density quantified using ImagePro® software.Results: The LGALS9 gene showed increased expression in cervical cancer samples. A higher expression level in SCC was related to better overall survival and to early clinical stages. GSEA showed that tumours with higher expression of LGALS9 were enriched in immune pathways such as interferon_alpha_response, and complement, the analysis of TIMER database showed a positive correlation between the expression level of LGALS9 and the abundance of tumour infiltrating immune cells. In addition, higher expression of galectin-9 was found in biopsies of SCC patients at early clinical stages, showing a trend of better survival.Conclusion: Higher expression levels of LGALS9 and galectin-9 in SCC were related to early clinical stages and better prognosis. GSEA and TIMER analysis suggested that galectin-9 could play an antitumor role in cervical SCC.Keywords: biomarker, galectin, cervical neoplasia, immune response, clinical stage, overall surviva

Mejora del rendimiento escolar, a través de utilizar en el aula estrategias de tipo cognitivo

1) Aumentar la capacidad de aprendizaje de los alumnos de segunda etapa de EGB, deprimidos socio-culturalmente o que presenten una deficiencia mental límite o ligera, mediante la aplicación del programa de enriquecimiento instrumental de Reuven Feuerstein. 2) Hipótesis nula: la aplicación o no del programa no influye en la puntuación obtenida en el factor verbal (PMA). 3) Hipótesis alternativa: si se ha aplicado el programa, los alumnos puntuan más alto en los factores: verbal, espacial, razonamiento, numérico y fluidez verbal y en el test de autoconcepto de Piers-Harris. Alumnos de sexto de EGB de 4 centros públicos (dos grupos, uno experimental y otro de control en cada centro), y de escuelas hogares (un sólo grupo), de la provincia de Ciudad Real. Se han diseñado dos tratamientos estadísticos diferentes (para un sólo grupo y para dos). Las variables utilizadas son: 1) Independientes: programa de enriquecimiento instrumental de Reuven Feuerstein, con dos niveles de tratamiento: el grupo experimental, programas escolares ordinarios y el instrumental: el grupo de control, sólo el currículum escolar. 2) Variables dependientes: aptitudes mentales primarias, del PMA; autoconcepto de Piers-Harris. Matrices progresivas de Raven, test de aptitudes mentales primarias, PMA, de Thurstone, test de autoconcepto de Piers-Harris. T de Student, T de Wilcoxon, percentiles de distribuciones F. Resultados de tipo cuantitativo: en el diseño de dos grupos, la aplicación del programa no ha producido mejoras estadísticamente significativas en los factores medidos. En el diseño de un solo grupo, se han encontrado diferencias estadísticamente significativas en los factores: verbal y autoconcepto. Resultados de tipo cualitativo: en un solo grupo experimental, respecto a las funciones cognitivas, en la fase de entrada se aprecian logros muy significativos referidos a la búsqueda impulsiva. Se observan asímismo, avances importantes en orientación espacio-temporal y en la capacidad para relacionar dos fuentes de información a la vez. En la fase de elaboración no se observan progresos. En la fase de salida hay mejoras. La mejora del autoconcepto es evidente. Las relaciones profesor-alumnos progresan y hay una interacción muy positiva entre ambos. En el diseño de dos grupos la aplicación del programa no ha producido los efectos deseados. El programa se presenta como ideal para aquellos individuos con capacidad intelectual normal y que sufren deprivación socio-cultural.Castilla La ManchaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 Planta; 28014 Madrid; Tel. +34917748000; Fax +34917748026; [email protected]

Evaluation of Serum Levels and Expression of Galectin-4 in Cervical Cancer

Galectin-4 has been reported to be altered in different cancer types. Its expression changes have been associated with early recurrence and metastasis. In cervical cancer (CC), galectin-4 has not been studied. The aim of the study was to determine the expression level and subcellular localization of galectin-4 in CC tissue and the concentration in the serum of patients with CC. For the analysis of serum levels of galectin-4, an ELISA assay was performed. To assess the expression in cervical tissue, immunohistochemical staining was performed. The results showed that the concentration of galectin-4 in the serum of patients with CC was higher (647.9 pg/ml) than that in the serum of women with normal cytology (382.1 pg/ml). The immunohistochemical analysis of CC samples showed a higher expression in keratinizing tumor than nonkeratinizing tumors and a trend of increased expression in tumors from patients with advanced clinical stage. In normal cervical tissue, galectin-4 was detected in the cytoplasm, and in tumor cells, the presence of galectin-4 was also detected in the nucleus, in both adenocarcinoma and squamous cervical cancer. The increase in serum concentration and different localization in the tumor cells suggest a possible role of galectin-4 in CC development