2,851 research outputs found
Diffusion-weighted MR imaging findings in an isolated abscess of the clivus
We report the finding of restricted diffusion in an isolated abscess of the clivus and discuss the imaging differential diagnosis, with an emphasis on the usefulness of diffusion-weighted imaging
Giant cell glioblastoma: review of the literature and illustrated case
Giant cell glioblastoma is an infrequent variety of glioblastoma (5% of the cases). It has deserved a separate category in the World Health Organization classification of grade IV tumors. The clinical, imaging, histological and immunohistochemical characteristics, and the genetic alterations are reviewed. Treatment and prognosis are discussed and updated. The case of a patient that survived 19 months and died of spinal leptomeningeal metastases is illustrated
Five supernova survey galaxies in the southern hemisphere. I. Optical and near-infrared database
The determination of the supernova (SN) rate is based not only on the number
of detected events, but also on the properties of the parent galaxy population.
This is the first paper of a series aimed at obtaining new, refined, SN rates
from a set of five SN surveys, by making use of a joint analysis of
near-infrared (NIR) data. We describe the properties of the 3838 galaxies that
were monitored for SNe events, including newly determined morphologies and
their DENIS and POSS-II/UKST I, 2MASS and DENIS J and Ks and 2MASS H
magnitudes. We have compared 2MASS, DENIS and POSS-II/UKST IJK magnitudes in
order to find possible systematic photometric shifts in the measurements. The
DENIS and POSS-II/UKST I band magnitudes show large discrepancies (mean
absolute difference of 0.4 mag), mostly due to different spectral responses of
the two instruments, with an important contribution (0.33 mag rms) from the
large uncertainties in the photometric calibration of the POSS-II and UKST
photographic plates. In the other wavebands, the limiting near infrared
magnitude, morphology and inclination of the galaxies are the most influential
factors which affect the determination of photometry of the galaxies.
Nevertheless, no significant systematic differences have been found between of
any pair of NIR magnitude measurements, except for a few percent of galaxies
showing large discrepancies. This allows us to combine DENIS and 2MASS data for
the J and Ks filters.Comment: 17 pages, 3 figures, 5 tables, published in Astrophysics, Vol. 52,
No. 1, 2009 (English translation of Astrofizika
Constraints for the nuclear parton distributions from Z and W production at the LHC
The LHC is foreseen to finally bring also the nuclear collisions to the TeV
scale thereby providing new possibilities for physics studies, in particular
related to the electro-weak sector of the Standard Model. We study here the Z
and W production in proton-lead and lead-lead collisions at the LHC,
concentrating on the prospects of testing the factorization and constraining
the nuclear modifications of the parton distribution functions (PDFs).
Especially, we find that the rapidity asymmetries in proton-nucleus collisions,
arising from the differences in the PDFs between the colliding objects, provide
a decisive advantage in comparison to the rapidity-symmetric nucleus-nucleus
case. We comment on how such studies will help to improve our knowledge of the
nuclear PDFs.Comment: The version accepted for publication in JHEP. New figures has been
added, and we also discuss the single charged lepton productio
Transparent dense sodium
Under pressure, metals exhibit increasingly shorter interatomic distances.
Intuitively, this response is expected to be accompanied by an increase in the
widths of the valence and conduction bands and hence a more pronounced
free-electron-like behaviour. But at the densities that can now be achieved
experimentally, compression can be so substantial that core electrons overlap.
This effect dramatically alters electronic properties from those typically
associated with simple free-electron metals such as lithium and sodium, leading
in turn to structurally complex phases and superconductivity with a high
critical temperature. But the most intriguing prediction - that the seemingly
simple metals Li and Na will transform under pressure into insulating states,
owing to pairing of alkali atoms - has yet to be experimentally confirmed. Here
we report experimental observations of a pressure-induced transformation of Na
into an optically transparent phase at 200 GPa (corresponding to 5.0-fold
compression). Experimental and computational data identify the new phase as a
wide bandgap dielectric with a six-coordinated, highly distorted
double-hexagonal close-packed structure. We attribute the emergence of this
dense insulating state not to atom pairing, but to p-d hybridizations of
valence electrons and their repulsion by core electrons into the lattice
interstices. We expect that such insulating states may also form in other
elements and compounds when compression is sufficiently strong that atomic
cores start to overlap strongly.Comment: Published in Nature 458, 182-185 (2009
Differential phosphorylation and n-terminal configuration of capsid subunits in parvovirus assembly and viral trafficking
publisher: Elsevier articletitle: Differential phosphorylation and n-terminal configuration of capsid subunits in parvovirus assembly and viral trafficking journaltitle: Virology articlelink: http://dx.doi.org/10.1016/j.virol.2018.02.018 content_type: article copyright: © 2018 Elsevier Inc. All rights reserved
Is the treatment with biological or non-biological DMARDS a modifier of periodontal condition in patients with rheumatoid arthritis?
Background and objective: Experimental models suggest the use of different therapy protocols in rheumatoid arthritis (RA) as modulators on periodontal condition. This study evaluated the effects of conventional drug treatment and anti-TNF therapy in patients with RA on microbiological and periodontal condition, establishing the association of markers of periodontal infection with indexes of rheumatic activity.
Materials and methods: One hundred seventy nine individuals with RA were evaluated (62 with anti-TNF-. and 115 with only DMARDs). The periodontal evaluation included plaque and gingival indexes, bleeding on probing (BOP), clinical attachment loss (CAL), pocket depth (PD) and subgingival plaque samples for microbiological analysis. Rheumatologic evaluations included a clinical examination, rheumatoid factor (RF), antibodies against cyclic-citrullinated peptides (ACPAs), and activity markers (DAS28-ERS), high sensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR).
Results: Anti-TNF-alpha therapy influenced periodontal microbiota with a higher frequency of T. denticola (p=0.01). Methotrexate combined with leflunomide exhibited a higher extension of CAL (p=0.005), and anti-TNF-alpha therapy with methotrexate was associated with a lower extension of CAL (p=0.05). The use of corticosteroids exerted a protective effect on the number of teeth (p=0.027). The type of DMARD affected P. gingivalis, T. forsythia and E. nodatum presence. Elevated ACPAs titers were associated with the presence of red complex periodontal pathogens (p=0.025). Bleeding on probing was associated with elevated CPR levels (p=0.05), and ESR was associated with a greater PD (p=0.044) and presence of red complex (p=0.030).
Conclusion: Different pharmacological treatments for RA affect the clinical condition and subgingival microbiota
Abcesso isolado do clivus achados em ressonância magnética convencional: estudo de difusão
Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias
INTRODUCTION: Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer's disease (AD), frontotemporal dementia (FTD), and Creutzfeldt-Jakob disease (CJD). METHODS: Unicentric cohort of 353 participants included healthy control (HC) subjects, AD continuum stages, genetic AD and FTD, and FTD and CJD. We measured cerebrospinal fluid neurofilament light (NF-L), neurogranin (Ng), 14-3-3, and YKL-40 proteins. RESULTS: Biomarkers showed differences in HC subjects versus AD, FTD, and CJD. Disease groups differed between them except AD versus FTD for YKL-40. Only NF-L differed between all stages within the AD continuum. AD and FTD symptomatic mutation carriers presented differences with respect to HC subjects. Applying the AT(N) system, 96% subjects were positive for neurodegeneration if 14-3-3 was used, 94% if NF-L was used, 62% if Ng was used, and 53% if YKL-40 was used. DISCUSSION: Biomarkers of synapse and neurodegeneration differentiate HC subjects from neurodegenerative dementias and between AD, FTD, and CJD. NF-L and 14-3-3 performed similar to total tau when AT(N) system was applied
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