46 research outputs found

    A study of professional development at three midwestern, urban, public, elementary schools with increased student achievement in reading

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    This study investigated principals\u27 and teachers\u27 perceptions about professional development and conditions for change. Specifically, the following research questions were answered: (1) How do principals describe professional development at their schools? (2) What professional development experiences did teachers report as having an effect on their teaching practice? and (3) What common factors or conditions did teachers at the three schools report as influencing whether they change their classroom practices after participating in professional development initiatives?;Data collection incorporated both qualitative and quantitative methodologies using principal interviews and teacher surveys. Simple descriptive statistics were used to analyze and describe professional development type and effect, impetus and effect, monitoring type and effect, follow-up type and effect, and student achievement examination and effect.;A four-step process was used to compile, classify and analyze qualitative data. Six overarching themes emerged that described principals\u27 perceptions of professional development and five conditions for change were identified from teachers\u27 responses

    Elementary French I & II

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    This Grants Collection for Elementary French I & II was created under a Round Four ALG Textbook Transformation Grant. These courses use the following web-based texts: Elementary French I: http://oer.galileo.usg.edu/languages-textbooks/1/ Elementary French II: http://oer.galileo.usg.edu/languages-textbooks/2/ Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/languages-collections/1000/thumbnail.jp

    An Exonic Splicing Enhancer within a Bidirectional Coding Sequence Regulates Alternative Splicing of an Antisense mRNA

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    The discovery of increasing numbers of genes with overlapping sequences highlights the problem of expression in the context of constraining regulatory elements from more than one gene. This study identifies regulatory sequences encompassed within two genes that overlap in an antisense orientation at their 3’ ends. The genes encode the α-thyroid hormone receptor gene (TRα or NR1A1) and Rev-erbα (NR1D1). In mammals TRα pre-mRNAs are alternatively spliced to yield mRNAs encoding functionally antagonistic proteins: TRα1, an authentic thyroid hormone receptor; and TRα2, a non-hormone-binding variant that acts as a repressor. TRα2-specific splicing requires two regulatory elements that overlap with Rev-erbα sequences. Functional mapping of these elements reveals minimal splicing enhancer elements that have evolved within the constraints of the overlapping Rev-erbα sequence. These results provide insight into the evolution of regulatory elements within the context of bidirectional coding sequences. They also demonstrate the ability of the genetic code to accommodate multiple layers of information within a given sequence, an important property of the code recently suggested on theoretical grounds

    Elementary Spanish I (UNG)

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    This Grants Collection for Elementary Spanish I was created under a Round Six ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/languages-collections/1001/thumbnail.jp

    Hola a Todos: Elementary Spanish I

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    This is a preliminary Open Textbook as created by the UNG Elementary Spanish I grant team using a Round Six Textbook Transformation Grant. The textbook is currently composed of original instructional materials created for the OER-based course, and the team is working to create a full open textbook at a later date. Separate files are included in the Additional Files section in a compressed .zip format for editing and quicker uploads/downloads within classes. Grammar and vocabulary pre-class activities, lectures, and post-class homework are included within these seven chapters: Introduction La Universidad La Familia El Tiempo Libre La Casa La Salud Comidas y Bebidas Accessible files with optical character recognition (OCR) and auto-tagging provided by the Center for Inclusive Design and Innovation.https://oer.galileo.usg.edu/languages-textbooks/1002/thumbnail.jp

    Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons

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    The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory and inhibits learning-induced cell survival and cell proliferation. In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons

    Strategies for recruiting Hispanic women into a prospective cohort study of modifiable risk factors for gestational diabetes mellitus

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    BACKGROUND: The purpose of this article was to describe effective strategies for recruitment of Hispanic women into a prospective cohort study of modifiable risk factors for gestational diabetes mellitus (GDM). Although Hispanic women have two to four times the risk of developing GDM compared with non-Hispanic white women, few GDM prevention studies have included Hispanic women. METHODS: The study was conducted in the ambulatory obstetrical practices of Baystate Medical Center located in a socioeconomically and ethnically diverse city in Massachusetts. The study employed a range of strategies to recruit Hispanic women based on a review of the literature as well as prior experience with the study population. RESULTS: Over a period of 32 months, a total of 851 Hispanic prenatal care patients were recruited. Among eligible women, 52.4% agreed to participate. Participants were young (70% <25 years), with low levels of education, and on public health insurance (81.5%); 88% were unmarried. Study design features such as use of bilingual recruiters, a flexible recruitment process, training recruiters to be culturally sensitive, use of culturally tailored materials, prescreening participants, participant compensation, seeking the cooperation of clinic staff, and continuous monitoring of recruitment goals emerged as important issues influencing recruitment. CONCLUSIONS: Findings suggest that investigators can successfully recruit pregnant women from ethnic minority groups of low socioeconomic status into observational studies. The study provides culturally appropriate recruitment strategies useful for practice-based settings recruiting Hispanic research participation

    Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein

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    Human rhinovirus (RV) infections are the principle cause of common colds and precipitate asthma and COPD exacerbations. There is currently no RV vaccine, largely due to the existence of ∼150 strains. We aimed to define highly conserved areas of the RV proteome and test their usefulness as candidate antigens for a broadly cross-reactive vaccine, using a mouse infection model. Regions of the VP0 (VP4+VP2) capsid protein were identified as having high homology across RVs. Immunization with a recombinant VP0 combined with a Th1 promoting adjuvant induced systemic, antigen specific, cross-serotype, cellular and humoral immune responses. Similar cross-reactive responses were observed in the lungs of immunized mice after infection with heterologous RV strains. Immunization enhanced the generation of heterosubtypic neutralizing antibodies and lung memory T cells, and caused more rapid virus clearance. Conserved domains of the RV capsid therefore induce cross-reactive immune responses and represent candidates for a subunit RV vaccine
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