La RSE y la comunicación en Mendoza

Se ha propuesto como objetivo general analizar cómo se desarrolla la responsabilidad empresaria en las empresas de la provincia de Mendoza, sus características, su forma de aplicación, pero por sobre todo la relación entre la responsabilidad social y el concepto de comunicación.Fil: Hernández, Marina . Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales.Fil: Echegaray, María. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales.Fil: Roca, Valeria. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales

The Degenerating Substantia Nigra as a Susceptible Region for Gene Transfer-Mediated Inflammation

Parkinson's disease (PD) is characterized by the progressive degeneration of neurons in the substantia nigra pars compacta (SN). The naïve SN is highly susceptible to inflammation. In addition, microglial activation in the degenerating SN displays distinct characteristics that increase the reactivity of the region towards inflammatory stimuli. On the other hand, gene therapy for PD has recently move forward into clinical settings, with PD being the neurodegenerative disorder with the highest number of Phase I/II gene therapy clinical trials approved and completed. These clinical trials are not targeting the SN, but this region is a certain candidate for future gene therapy interventions. Here, the unique immune-related properties of the degenerating SN in the context of a putative gene therapy intervention are reviewed. Several variables affecting the host response to gene delivery such as vector type and dosage, age and stage of disease of patients, and method of gene delivery and transgene used are discussed. Finally, approaches to diminish the risk of immune-mediated toxicity by gene transfer in the SN are presented

Differential vulnerability of adult neurogenesis by adult and prenatal inflammation: role of TGF-β1

Peripheral inflammation, both during the prenatal period and in adulthood, impairs adult neurogenesis. We hypothesized that, similar to other programming effects of prenatal treatments, only prenatal inflammation causes long-term consequences in adult neurogenesis and its neurogenic niche. To test this, pregnant Wistar rats were subcutaneously injected with lipopolysaccharide (LPS; 0.5 mg/kg) or saline solution every other day from gestational/embryonic day (GD) 14-20. In addition adult animals were injected with a single intraperitoneal saline or LPS injection (1 mg/kg) and the effects on neurogenesis were assessed 7 days later. Alternatively, to evaluate long-term consequences of adult LPS injections, LPS (1 mg/kg) was administered peripherally to adult rats four times every other day, and the effects on neurogenesis were assessed 60 days later. Prenatal and adult LPS treatments reduced adult neurogenesis and provoked specific microglial (but not astroglial) activation in the dentate gyrus (DG). However, only prenatal inflammation-mediated effects were long-lasting (at least 60 days). Moreover, these effects were specific to the DG since the Subventricular Zone (SVZ) and the Rostral Migratory Stream (RMS) were not affected. In addition, these stimuli caused differential effects on the molecular components of the neurogenic niche; only prenatal LPS treatment reduced the local levels of TGF-β1 mRNA in the DG. Finally, TGF-β1 exerted its pro-neurogenic effects via the Smad 2/3 pathway in a neural stem cell culture. Taken together, these data add evidence to the duration, regional specificity and dramatic consequences of prenatal immune programming on CNS physiology, compared with the limited response observed in the adult brain.Fil: Graciarena, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Roca, Valeria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Mathieu, Patricia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Depino, Amaicha Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

Nitrogen activation of carbon-encapsulated zero-valent iron nanoparticles and influence of the activation temperature on heavy metals removal

Nanoparticles of zero-valent iron (nZVI) represent a promising agent for environmental remediation. This is due to their core-shell structure which presents the characteristics of both metallic and oxidised iron, leading to sorption and reductive precipitation of metal ions. Nevertheless, nZVI application presents some limitations regarding their rapid oxidation and aggregation in the media which leads to the delivery of the ions after some hours (the "aging effect"). To address these issues, modifications of nZVI structure and synthesis methods have been developed in the last years. The aging problem was solved by using nZVI encapsulated inside carbon spheres (CE-nZVI), synthetized through Hydrothermal Carbonization (HTC). Results showed high heavy metals removal percentage. Furthermore, CE-nZVI were activated with nitrogen in order to increase the metallic iron content. The aim of this study was to test CE-nZVI post-treated with nitrogen at different temperatures in heavy metals removal, demonstrating that the influence of the temperature was negligible in nanoparticles removal efficiency.This work was financially supported by University of Milano-Bicocca fund (2016-ATESP-0597) and University of Alicante (UAFPU2013-5791)

Conservation Gaps Associated with Threatened Wildlife in Chimborazo Province

The identification of conservation gaps through a systemic planning process allows for the design and evaluation of initiatives for determining conservation areas at different geographical scales. The purpose of this study was to determine the conservation gaps associated with threatened wildlife in Chimborazo, Ecuador. A documentary research was used including a systematic review of 26 geographic and bibliographic information sources on 10 wildlife variables, a multicriteria analysis in GIS using six criteria, the statistical analysis of independent variables using a Chi-square test, and the development of a correspondence analysis. The results showed that in Chimborazo province, 311 species of wildlife were registered, of which 13% are in a degree of threat. To mitigate the problems associated with the loss of wildlife, two strategies are required, mainly through the leadership and active participation of the 10 public sector actors. In addition, it was identified that the conservation gaps associated with threatened wildlife are mainly found in the “paramo” ecosystem and comprise an area of 143,302 ha, which corresponds to 22% of province’s extension. This information should be used by the institutions related to the management of the natural resources of the province to deepen the studies on the ranges of distribution of species in threat category and promote actions that allow the conservation and sustainable use of the natural heritage from the province. Keywords: Fauna, Threats, Conservation gaps, Multi-criteria analysis. Resumen La identificación de vacíos de conservación a través de un proceso de planificación sistémica permite diseñar y evaluar iniciativas para la implementación de áreas de conservación en diferentes escalas geográficas. El propósito de este estudio fue determinar los vacíos de conservación asociados a la fauna con categoría de amenaza en la provincia de Chimborazo. Los métodos empleados contemplaron una investigación documental, mediante la revisión sistemática de 26 fuentes información geográfica y bibliográfica sobre 10 variables de la fauna, un análisis multicriterio en SIG a través de la aplicación de 6 criterios, y el análisis estadístico, mediante la aplicación de una prueba chi cuadrado de independencia y el desarrollo de un análisis de correspondencia. Los resultados reflejan que en la provincia de Chimborazo se registraron 311 especies de fauna, de las cuales el 13% se encuentran en una categoría de amenaza. Para mitigar la problemática asociada a la perdida de fauna silvestre se requiere la implementación de dos estrategias, a través del liderazgo y la participación de 10 actores del sector público, principalmente. Además, se identificó que los vacíos de conservación asociados a la fauna con categoría de amenaza se encuentran principalmente en el ecosistema páramo y comprende una extensión de 143.302 ha, que corresponde al 22 % de la extensión de la provincia. Esta información debe ser utilizada por las instituciones relacionadas al manejo de los recursos naturales de la provincia, para profundizar los estudios sobre los rangos de distribución de especies en categoría de amenaza, y para impulsar acciones que permitan la conservación y el aprovechamiento sostenible del patrimonio natural de la provincia. Palabras Clave: Fauna, Amenazas, Vacíos de conservación, Análisis multicriterio

Reference Gene Validation for RT-qPCR in PBMCs from Asthmatic Patients with or without Obesity

Obesity is known to impair the efficacy of glucocorticoid medications for asthma control. Glucocorticoid-induced gene expression studies may be useful to discriminate those obese asthmatic patients who present a poor response to glucocorticoids. The expression of genes of interest is normalized with respect to reference genes (RGs). Ideally, RGs have a stable expression in different samples and are not affected by experimental conditions. The objective of this work was to analyze suitable RGs to study the role of glucocorticoid-induced genes in obese asthmatic patients in further research. The gene expression of eight potential RGs (GUSB, B2M, POLR2A, PPIA, ACTB, GAPDH, HPRT1, and TBP) was assessed with reverse transcription-quantitative polymerase chain reaction in peripheral blood mononuclear cells (PBMCs) from asthmatic, obese asthmatic, and healthy individuals. Their stability was analyzed using four different algorithms-BestKeeper, ?Ct, geNorm, and NormFinder. geNorm analysis recommended the use of a minimum of three genes for normalization. Moreover, intergroup variation due to the treatment was calculated by NormFinder, which found that B2M was the gene that was least affected by different treatments. Comprehensive rankings indicated GUSB and HPRT1 as the best RGs for qPCR in PBMCs from healthy and asthmatic subjects, while B2M and PPIA were the best for obese asthmatic subjects. Finally, our results demonstrated that B2M and HPRT1 were the most stable RGs among all groups, whereas ACTB, TBP, and GAPDH were the worst shared ones

Servicio de Tours Virtuales en vivo y Personalización de Acabados en Tiempo Rea

Vivimos en un mundo donde la tecnología va creciendo con gran rapidez, durante la pandemia muchos negocios que ofertaban sus productos y servicios de forma presencial han tenido que adaptarse al mundo digital para poder sobrevivir. El mundo inmobiliario se vio estancado y duramente golpeado económicamente durante el inicio de la pandemia, puesto a que las personas interesadas en adquirir un inmueble ya no podían salir a visitar las casetas de ventas inmobiliarias y los departamentos por temor a contraer el virus. Por ende, las inmobiliarias comenzaron a reducir sus ventas y muchos proyectos inmobiliarios se estancaron. Nuestra investigación nos ha permitido identificar grandes limitaciones que enfrentan las empresas inmobiliarias y también hemos identificado soluciones para que este rubro pueda ir digitalizándose. Bajo esta necesidad nace Formula Inmobiliaria, una empresa evocada a brindar un soporte integral a las inmobiliarias de Lima y Callao con la gestión de leads, marketing inmobiliario y tour virtual con edición de acabados a tiempo real. Un servicio 100% digital, innovador y tecnológico. Formula Inmobiliaria se posicionará como empresa pionera a nivel nacional al utilizar esta tecnología vanguardista de tour virtual con edición de acabados a tiempo real. Esto debido a que, otras empresas emplean para sus tours a distancia programas tales como: zoom, meet, skype, etc. las cuales no permiten una interacción fluida con el cliente, dañando la experiencia de compra. Formula Inmobiliaria se compromete en brindarle a nuestro cliente inmobiliario todo el apoyo necesario para que sus asesores inmobiliarios puedan cerrar ventas rápidas.We live in a world where technology is growing rapidly, during the pandemic many businesses that offered their products and services in person have had to adapt to the digital world in order to survive. The real estate world was stagnant and hard hit economically during the beginning of the pandemic, since people interested in acquiring a property could no longer go out to visit real estate sales booths and apartments for fear of contracting the virus. As a result, real estate companies began to reduce their sales and many real estate projects stalled. Our research has allowed us to identify major limitations that real estate companies face and we have also identified solutions so that this item can be digitized. Under this need, Formula Inmobiliaria was born, a company evoked to provide comprehensive support to real estate agencies in Lima and Callao with lead management, real estate marketing and virtual tour with real-time finishing editing. A 100% digital, innovative and technological service. Formula Inmobiliaria will position itself as a pioneering company at the national level by using this avant-garde virtual tour technology with real-time finishing editing. This is because other companies use programs such as: zoom, meet, skype, etc. for their remote tours. which do not allow a fluid interaction with the customer, damaging the shopping experience. Formula Inmobiliaria is committed to providing our real estate client with all the necessary support so that their real estate advisers can close quick sales.Trabajo de investigació

Postoperative complications of exodontics in patients treated in the clinic of the course of Surgery A (FOUNLP). Years 2018-2019-2020

Las principales complicaciones registradas son: la Alveolitis (seca o húmeda) y la hemorragia. De dichas complicaciones se percibe que la Alveolitis es la complicación más frecuente de la exodoncia dentaria. El dolor es probablemente el principal motivo de consulta en las urgencias estomatológicas. En las mismas, el estomatólogo se enfrenta a diario con dolores principalmente agudos, provenientes de estructuras dentarias o de los tejidos subyacentes. Los distintos estudios realizados por diversos autores revelan que la frecuencia varía entre el 1 y 4 % de todas las extracciones dentales y puede llegar del 20 al 30 % en terceros molares mandibulares. Es más frecuente en el sexo femenino y la mayoría de los casos se observan entre la tercera y cuarta décadas de la vida. Esta urgencia estomatológica tiene gran repercusión, ya que a pesar de que el dolor que sufre el paciente puede ser moderado, casi siempre es constante, perturbador, de carácter insoportable, irradiado, persiste por varios días e impide, en la mayoría de los casos, la actividad normal del paciente, por lo que limita su desenvolvimiento laboral y social, en algunos casos, hasta por 20 días. Describir la frecuencia de alveolitis dentaria y los específicos relacionar la alveolitis dentaria con edad,relacionar la alveolitis dentaria con sexo, relacionar la alveolitis dentaria con grupo dentario, relacionar la alveolitis dentaria con localización (maxilar superior o inferior), relacionar la alveolitis dentaria con tabaquismo.The main complications are: Alveolitis (dry or wet) and bleeding. From these complications it is perceived that alveolitis is the most frequent complication of dental extraction. Pain is probably the main reason for consultation in stomatologic emergencies. In these, the stomatologist confronts daily with mainly acute pains, coming from dental structures or underlying tissues. The different studies performed by different authors reveal that the frequency varies between 1 and 4% of all dental extractions and can reach 20 to 30% in third mandibular molars. It is more frequent in the female sex and most cases are seen between the third and fourth decades of life. This stomatological urgency has great repercussion, since although the pain that the patient suffers may be moderate, it is almost always constant, disturbing, unbearable, irradiated, persists for several days and prevents, in most cases, The normal activity of the patient, so limiting their work and social development, in some cases, up to 20 days.To describe the frequency of dental alveolitis and to relate dental alveolitis to age, to relate dental alveolitis to sex, to relate dental alveolitis to dental group, to relate dental alveolitis with location (upper or lower jaw), to relate alveolitis with smoking.Facultad de Odontologí

Depression symptoms and suicide risk of internal medicine residents before and after first year of the COVID-19 pandemic

IntroductionDepression is a mental health disorder characterized by the presence of sadness or loss of the ability to feel pleasure, with a high incidence in patients with COVID 19. The investigations have focused on patient care and little on the care of health personnel, these being the ones with the highest mortality rate, so the objective of the study was to investigate the prevalence of depression symptoms and suicide risk and understand the association of depressive disorder and suicide risk with levels of serum cholesterol and low levels of serum cortisol among internal medicine fellows in a specialist medical hospital in Leon, Guanajuato, Mexico, before and after COVID-19.MethodsIn this longitudinal study, internal medicine residents were initially monitored for 2months before starting to care for patients with COVID-19. Participants were asked to fill out depression symptoms and suicide risk surveys. We measured the serum cholesterol and cortisol of each participant, and again after 11months of treating COVID-19 patients.ResultsDepression symptoms and suicide risk were assessed; significant differences were found between the two time periods for depression (p < 0.01), and no difference was found for suicide risk (p = 0.182). We found a significant correlation between serum cholesterol levels and suicide risk (r = 0.366, p < 0.01); we also found differences in serum cortisol levels (p < 0.01) and cholesterol (p < 0.0001) before and after the pandemic.ConclusionCaring for patients with COVID-19 in the hospital contributed to an increase in levels of depression symptoms and suicidal ideation, as well as differences in levels of cortisol and cholesterol in resident physicians of internal medicine; among the possible reasons for this change could be the conditions of personal protection while treating patients, the uncertainty in the first months of not knowing how the virus was transmitted and not having or knowing when vaccinations would be available, as well as the lack of a strategy of adequate mental health support from the institutions dedicated to their academic training