On the Structure of Dark Matter Halos at the Damping Scale of the Power Spectrum with and without Relict Velocities

We report a series of high-resolution cosmological N-body simulations designed to explore the formation and properties of dark matter halos with masses close to the damping scale of the primordial power spectrum of density fluctuations. We further investigate the effect that the addition of a random component, v_rms, into the particle velocity field has on the structure of halos. We adopted as a fiducial model the Lambda Warm Dark Matter cosmology with a non-thermal sterile neutrino mass of 0.5 keV. The filtering mass corresponds then to M_f = 2.6x10^12 M_sun/h. Halos of masses close to M_f were simulated with several million of particles. The results show that, on one hand, the inner density slope of these halos (at radii <~0.02 the virial radius Rvir) is systematically steeper than the one corresponding to the NFW fit or to the CDM counterpart. On the other hand, the overall density profile (radii larger than 0.02Rvir) is less curved and less concentrated than the NFW fit, with an outer slope shallower than -3. For simulations with v_rms, the inner halo density profiles flatten significantly at radii smaller than 2-3 kpc/h (<~0.010-0.015Rvir). A constant density core is not detected in our simulations, with the exception of one halo for which the flat core radius is ~1 kpc/h. Nevertheless, if ``cored'' density profiles are used to fit the halo profiles, the inferred core radii are ~0.1-0.8 kpc/h, in rough agreement with theoretical predictions based on phase-space constrains, and on dynamical models of warm gravitational collapse. A reduction of v_rms by a factor of 3 produces a modest decrease in core radii, less than a factor of 1.5. We discuss the extension of our results into several contexts, for example, to the structure of the cold DM micro-halos at the damping scale of this model.Comment: 13 pages, 6 figures, accepted for publication in The Astrophysical Journa

Relationship Between Periodontal Disease (Periodontitis) and Major Vascular Events. A Case- Control Study. Enperiva Studio

Introduction: Periodontal and vascular disease share not only risk factors such as smoking and diabetes, but also a complex and multifactorial process of chronic inflammation. Materials and Methods: We carried out “case-control study”. The cases were included in a non-randomized manner and they have to had a major vascular event at entry. Results: The proportion of patients with periodontitis was significantly higher in cases than in controls (p = 0.02). The presence of gingivitis was almost the same in both groups (p = 0.99). Conclusions: The present study demonstrated that not only periodontal disease is strongly associated with major vascular events but also that it was independent of traditional risk factors for vascular disease

The Second Wind in McArdle Patients: Fitness Matters

Glucogenosis tipo 5; Deficiencia de miofosforilasa; Umbral de ventilaciónGlycogenosis type 5; Myophosphorylase deficiency; Ventilatory thresholdGlucogenosi tipus 5; Deficiència de miofosforilasa; Llindar ventilatoriBackground: The “second wind” (SW) phenomenon—commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i.e., the actual “SW”) until 6–10 min has elapsed—is an almost unique feature of McArdle disease that limits adherence to an active lifestyle. In this regard, an increase in the workload eliciting the SW could potentially translate into an improved patients’ exercise tolerance in daily life. We aimed to determine whether aerobic fitness and physical activity (PA) levels are correlated with the minimum workload eliciting the SW in McArdle patients—as well as with the corresponding heart rate value. We also compared the SW variables and aerobic fitness indicators in inactive vs. active patients. Methods: Fifty-four McArdle patients (24 women, mean ± SD age 33 ± 12 years) performed 12-min constant-load and maximum ramp-like cycle-ergometer tests for SW detection and aerobic fitness [peak oxygen uptake (VO2peak) and workload and ventilatory threshold] determination, respectively. They were categorized as physically active/inactive during the prior 6 months (active = reporting ≥150 min/week or ≥75 min/week in moderate or vigorous-intensity aerobic PA, respectively) and were also asked on their self-report of the SW. Results: Both peak and submaximal indicators of aerobic fitness obtained in the ramp tests were significantly correlated with the workload of the SW test, with a particularly strong correlation for the VO2peak and peak workload attained by the patients (both Pearson’s coefficients > 0.70). Twenty (seven women) and 24 patients (18 women) were categorized as physically active and inactive, respectively. Not only the aerobic fitness level [∼18–19% higher values of VO2peak (ml⋅kg–1⋅min–1)] but also the workload of the SW tests was significantly higher in active than in inactive patients. All the inactive patients reported that they experienced the SW during walking/brisk walking in daily life, whereas active patients only reported experiencing this phenomenon during more strenuous activities (very brisk walking/jogging and bicycling). Conclusion: A higher aerobic fitness and an active lifestyle are associated with a higher workload eliciting the so-called SW phenomenon in patients with McArdle disease, which has a positive impact on their exercise tolerance during daily living.Research by AL, CF-L, GN-G, MM, and TP was funded by the Instituto de Salud Carlos III (ISCIII) and Fondos Feder (grants PI18/00139, PI20/00645, PI18/00713, PI17/00093, and PI19/01313). CF-L and GN-G were supported by Miguel Servet contracts (CP18/00034 and CPII19/00021, respectively) from ISCIII. The funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the manuscript for publication

Performance and reference data in the jump squat at different relative loads in elite sprinters, rugby players, and soccer players

The aims of this study were to compare the outcomes and provide reference data for a set of barbell mechanical parameters collected via a linear velocity transducer in 126 male sprinters (n = 62), rugby players (n = 32), and soccer players (n = 32). Bar-velocity, bar-force, and bar-power outputs were assessed in the jump-squat exercise with jump-squat height determined from bar-peak velocity. The test started at a load of 40% of the athletes\u27 body mass (BM), and a load of 10% of BM was gradually added until a clear decrement in the bar power was observed. Comparisons of bar variables among the three sports were performed using a one-way analysis of variance. Relative measures of bar velocity, force, and power, and jump-squat height were significantly higher in sprinters than in rugby (difference ranging between 5 and 35%) and soccer (difference ranging between 5 and 60%) players across all loads (40-110% of BM). Rugby players exhibited higher absolute bar-power (mean difference = 22%) and bar-force (mean difference = 16%) values than soccer players, but these differences no longer existed when the data were adjusted for BM (mean difference = 2.5%). Sprinters optimized their bar-power production at significantly greater relative loads (%BM) than rugby (mean difference = 22%) and soccer players (mean difference = 25%); nonetheless, all groups generated their maximum bar-power outputs at similar bar velocities. For the first time, we provided reference values for the jump-squat exercise for three different bar-velocity measures (i.e., mean, mean propulsive, and peak velocity) for sprinters, rugby players, and soccer players, over a wide range of relative loads. Practitioners can use these reference values to monitor their athletes and compare them with top-level sprinters and team-sport players

Effects of combining a ketogenic diet with resistance training on body composition, strength, and mechanical power in trained individuals: a narrative review

Ketogenic diets (KD) have gained popularity in recent years among strength-trained individuals. The present review summarizes current evidence—with a particular focus on randomized controlled trials—on the effects of KD on body composition and muscle performance (strength and power output) in strength-trained individuals. Although long-term studies (>12 weeks) are lacking, growing evidence supports the effectiveness of an ad libitum and energy-balanced KD for reducing total body and fat mass, at least in the short term. However, no or negligible benefits on body composition have been observed when comparing hypocaloric KD with conventional diets resulting in the same energy deficit. Moreover, some studies suggest that KD might impair resistance training-induced muscle hypertrophy, sometimes with concomitant decrements in muscle performance, at least when expressed in absolute units and not relative to total body mass (e.g., one-repetition maximum). KD might therefore be a beneficial strategy for promoting fat loss, although it might not be a recommendable option to gain muscle mass and strength/power. More research is needed on the adoption of strategies for avoiding the potentially detrimental effect of KD on muscle mass and strength/power (e.g., increasing protein intake, reintroduction of carbohydrates before competition). In summary, evidence is as yet scarce to support a major beneficial effect of KD on body composition or performance in strength-trained individuals. Furthermore, the long-term effectiveness and safety of this type of diet remains to be determined

Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease

Glycogen store disease; Muscle fatigue; Substrate oxidationEnfermedad de almacenamiento de glucógeno; Fatiga muscular; Oxidación del sustratoMalaltia d'emmagatzematge de glucogen; Fatiga muscular; Oxidació del substratCarbohydrate availability affects fat metabolism during exercise; however, the effects of complete muscle glycogen unavailability on maximal fat oxidation (MFO) rate remain unknown. Our purpose was to examine the MFO rate in patients with McArdle disease, comprising an inherited condition caused by complete blockade of muscle glycogen metabolism, compared to healthy controls. Nine patients (three women, aged 36 ± 12 years) and 12 healthy controls (four women, aged 40 ± 13 years) were studied. Several molecular markers of lipid transport/metabolism were also determined in skeletal muscle (gastrocnemius) and white adipose tissue of McArdle (Pygm p.50R∗/p.50R∗) and wild-type male mice. Peak oxygen uptake (V˙O2peak), MFO rate, the exercise intensity eliciting MFO rate (FATmax) and the MFO rate-associated workload were determined by indirect calorimetry during an incremental cycle-ergometer test. Despite having a much lower V˙O2peak (24.7 ± 4 vs. 42.5 ± 11.4 mL kg−1 min−1, respectively; P < 0.0001), patients showed considerably higher values for the MFO rate (0.53 ± 0.12 vs. 0.33 ± 0.10 g min−1, P = 0.001), and for the FATmax (94.4 ± 7.2 vs. 41.3 ± 9.1 % of V˙O2peak, P < 0.0001) and MFO rate-associated workload (1.33 ± 0.35 vs. 0.81 ± 0.54 W kg−1, P = 0.020) than controls. No between-group differences were found overall in molecular markers of lipid transport/metabolism in mice. In summary, patients with McArdle disease show an exceptionally high MFO rate, which they attained at near-maximal exercise capacity. Pending more mechanistic explanations, these findings support the influence of glycogen availability on MFO rate and suggest that these patients develop a unique fat oxidation capacity, possibly as an adaptation to compensate for the inherited blockade in glycogen metabolism, and point to MFO rate as a potential limiting factor of exercise tolerance in this disease.Research by the IA and CR-L group is funded by the Biomedical Research Networking Centre on Frailty and Healthy Aging (CIBERFES, CB16/10/00314 and CB16/10/00477). IR-G is supported by a postdoctoral contract from Universidad de Castilla–La Mancha (2021/5937). PLV is supported by a Sara Borrell contract from Instituto de Salud Carlos III (CD21/00138). Research by AL and TP is funded by the Spanish Ministry of Economy and Competitiveness and Fondos FEDER (PI18/00139 and PI19/01313, respectively)

Mortality from mental disorders and suicide in male professional American football and soccer players: A meta-analysis

Objective To determine the risk of mortality from mental disorders and suicide in professional sports associated with repeated head impacts. Methods A systematic search was performed in PubMed, Web of Science, Scopus, and SPORTDiscus (since inception to June 8, 2021) to find studies comparing the incidence of mortality from mental disorders or suicide in former or active professional athletes of sports characterized by repeated head impacts vs athletes with no such exposure or the general non-athletic population. Results Seven retrospective studies of moderate-to-high quality that included data from boxers and from basketball, ice hockey, soccer, and National Football League (NFL) players, respectively (total = 27 477 athletes, 100% male) met all inclusion criteria. Former male NFL players (n = 13 217) had a lower risk of mortality from mental disorders (standard mortality rate [SMR] = 0.30; 0.12-0.77; p = 0.012) and suicide (SMR = 0.54; 0.37-0.78; p < 0.001) than the general population. This finding was also corroborated in male soccer players (n = 13,065; SMR = 0.55; 0.46-0.67; p < 0.001). Male athletes participating in sports associated with repeated head impacts (n = 18,606) had also a lower risk of all-cause, cardiovascular disease (CVD), and cancer mortality (all p < 0.01) than the general population. Conclusions Participation of male athletes in American football or soccer at the professional level might confer a certain protective effect against mortality from mental disorders or suicide, besides its association with a lower risk of all-cause, CVD, or cancer-related mortality.This work was supported by the Spanish Ministry of Science and Innovation (Instituto de Salud Carlos III) [grant PI18/00139, AL

Low aerobic capacity in McArdle disease: A role for mitochondrial network impairment?

Aerobic capacity; Glycogen; McArdle diseaseCapacidad aeróbica; Glucógeno; Enfermedad de McArdleCapacitat aeròbica; Glicogen; Malaltia de McArdleBackground McArdle disease is caused by myophosphorylase deficiency and results in complete inability for muscle glycogen breakdown. A hallmark of this condition is muscle oxidation impairment (e.g., low peak oxygen uptake (VO2peak)), a phenomenon traditionally attributed to reduced glycolytic flux and Krebs cycle anaplerosis. Here we hypothesized an additional role for muscle mitochondrial network alterations associated with massive intracellular glycogen accumulation. Methods We analyzed in depth mitochondrial characteristics-content, biogenesis, ultrastructure-and network integrity in skeletal-muscle from McArdle/control mice and two patients. We also determined VO2peak in patients (both sexes, N = 145) and healthy controls (N = 133). Results Besides corroborating very poor VO2peak values in patients and impairment in muscle glycolytic flux, we found that, in McArdle muscle: (a) damaged fibers are likely those with a higher mitochondrial and glycogen content, which show major disruption of the three main cytoskeleton components-actin microfilaments, microtubules and intermediate filaments-thereby contributing to mitochondrial network disruption in skeletal muscle fibers; (b) there was an altered subcellular localization of mitochondrial fission/fusion proteins and of the sarcoplasmic reticulum protein calsequestrin-with subsequent alteration in mitochondrial dynamics/function; impairment in mitochondrial content/biogenesis; and (c) several OXPHOS-related complex proteins/activities were also affected. Conclusions In McArdle disease, severe muscle oxidative capacity impairment could also be explained by a disruption of the mitochondrial network, at least in those fibers with a higher capacity for glycogen accumulation. Our findings might pave the way for future research addressing the potential involvement of mitochondrial network alterations in the pathophysiology of other glycogenoses.The present study was funded by grants received from the Fondo de Investigaciones Sanitarias (FIS, PI17/02052, PI18/00139, PI19/01313, and PI20/00645) and cofunded by ‘Fondos FEDER’. Gisela Nogales-Gadea and Carmen Fiuza-Luces are supported by the Miguel Servet research contracts (ISCIII CD14/00032 and CP18/00034, respectively and cofounded by Fondos FEDER′). Research by Pedro L. Valenzuela is funded by a postdoctoral contract granted by Instituto de Salud Carlos III (Sara Borrell, CD21/00138). Monica Villarreal Salazar is supported by the Mexican National Council for Science and Technology (CONACYT)

Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis

Background: Advances in cancer treatments, particularly the development of radiation therapy, have led to improvements in survival outcomes in children with brain tumors. However, radiation therapy is associated with significant long-term neurocognitive morbidity. The present systematic review and meta-analysis aimed to compare the neurocognitive outcomes of children and adolescents with brain tumors treated with photon radiation (XRT) or proton therapy (PBRT). Methods: A systematic search was conducted (PubMed, Embase, Cochrane, and Web of Science from inception until 02/01/2022) for studies comparing the neurocognitive outcomes of children and adolescents with brain tumors treated with XRT vs. PBRT. The pooled mean differences (expressed as Z scores) were calculated using a random effects method for those endpoints analyzed by a minimum of three studies. Results: Totally 10 studies (n = 630 patients, average age range: 1–20 years) met the inclusion criteria. Patients who had received PBRT achieved significantly higher scores (difference in Z scores ranging from 0.29–0.75, all P 0.05 in main analyses or sensitivity analyses) were found for nonverbal memory, verbal working memory and working memory index, processing speed index, or focused attention. Conclusions: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.14 página

Squat and countermovement jump performance across a range of loads: A comparison between Smith machine and free weight execution modes in elite sprinters

The aims of this study were to: 1) provide and compare the height achieved during Smith machine (SM) and free weight (FW) loaded jumps executed over a wide spectrum of loads (40–120 % of body mass [BM]); and 2) test the difference between loaded and unloaded squat jump (SJ) and countermovement jump (CMJ) attempts in ten highly trained male sprinters. On the first visit, athletes performed unloaded SJ and CMJ, loaded SJ with loads corresponding to 40, 60, 80, 100, and 120 % BM, and loaded CMJ at 100% BM using an Olympic barbell (FW). On the second visit, they performed loaded SJ and CMJ tests under the same loading conditions on the SM device and, subsequently, a half-squat one-repetition maximum (1RM) assessment. The relative strength (RS = 1RM/BM) of the athletes was 2.54 ± 0.15. Loaded SJ performance was similar between SM and FW, and across all loading conditions. Differences in favour of CMJ (higher jump heights compared with SJ) were superior in the unloaded condition but decreased progressively as a function of loading. In summary, sprinters achieved similar SJ heights across a comprehensive range of loads, regardless of the execution mode (FW or SM). The positive effect of the countermovement on jump performance is progressively reduced with increasing load