Quantum integrability of quadratic Killing tensors

Quantum integrability of classical integrable systems given by quadratic Killing tensors on curved configuration spaces is investigated. It is proven that, using a "minimal" quantization scheme, quantum integrability is insured for a large class of classic examples.Comment: LaTeX 2e, no figure, 35 p., references added, minor modifications. To appear in the J. Math. Phy

A series of vectors for fungal transformation

We report a new fungal selectable marker that confers resistance to chlorimuron ethyl, a sulfonylurea herbicide. This gene as well as genes that confer resistance to hygromycin and bialaphos have been engineered to be compact and to eliminate sites for most common restriction enzymes. These three selectable markers have been used to construct a series of vectors for fungal transformation

A miniprep procedure for isolating genomic DNA from Magnoporthe grisea

We have developed a simple miniprep procedure for the isolation of genomic DNA from the ascomycete Magnaporthe grisea. This pathogen of many grasses, including rice, has a moderate growth rate and produces intermediate to low numbers of conidia when grown in culture. Thus, in our previous DNA preparation procedure we inoculated swirling liquid cultures with mycelium that had been fragmented in a blender rather than with conidia. The mycelium obtained from these cultures was ground in liquid nitrogen for DNA extraction. Though the quantity and quality of DNA obtained by this method is satisfactory, the technique is too laborious for analysis of many strains. We developed the procedure described below to eliminate the need to fragment mycelium in a blender to inoculate cultures and to eliminate the need to grind mycelium in liquid nitrogen for DNA extraction. The new procedure, which relies on the enzymatic removal of cell walls and the lysis of protoplasts, should be readily adaptable to other filamentous fungi with growth characteristics similar to those of M. grisea

Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal

Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis. However, increasing numbers of patients are now being informed that their clinical findings are due to MC activation (MCA) that is neither associated with mastocytosis nor with a defined allergic or inflammatory reaction. In other patients with MCA, MCs appear to be clonal cells, but criteria for diagnosing mastocytosis are not met. A working conference was organized in 2010 with the aim to define criteria for diagnosing MCA and related disorders, and to propose a global unifying classification of all MC disorders and pathologic MC reactions. This classification includes three types of `MCA syndromes' (MCASs), namely primary MCAS, secondary MCAS and idiopathic MCAS. MCA is now defined by robust and generally applicable criteria, including (1) typical clinical symptoms, (2) a substantial transient increase in serum total tryptase level or an increase in other MC-derived mediators, such as histamine or prostaglandin D 2, or their urinary metabolites, and (3) a response of clinical symptoms to agents that attenuate the production or activities of MC mediators. These criteria should assist in the identification and diagnosis of patients with MCAS, and in avoiding misdiagnoses or overinterpretation of clinical symptoms in daily practice. Moreover, the MCAS concept should stimulate research in order to identify and exploit new molecular mechanisms and therapeutic targets. Copyright (C) 2011 S. Karger AG, Base

Winter Wheat Variety Response to Timing and Number of Fungicide Applications During the 2019–2020 Growing Season in Kansas

The objective of this project was to evaluate the yield response of different winter wheat varieties to different fungicide management treatments during the 2019–2020 growing season in Kansas. Fourteen varieties were evaluated under four fungicide treatments (no fungicide, application either at jointing, heading, or at both stages) in five locations across Kansas in a split-plot design. Disease incidence was assessed approximately 20-d after each fungicide application. Septoria blotch and tan spot were the most prevalent early-season diseases at the studied fields, while stripe rust, leaf rust, and tan spot prevailed late in the season. Late-season diseases had a greater effect on grain yield when compared to early-season diseases. While varieties responded differently to fungicide management, there was an overall yield increase of 1.8 bushels per acre resulting from the jointing fungicide application; 3.3 bu/a from the heading fungicide; and 4.3 bu/a from the combination of both applications. Overall, susceptible varieties had a greater response to fungicide management compared to varieties with intermediate or high levels of genetic resistance. Late-season drought and heat stress affected three out of five locations (Belleville, Conway Springs, and Hutchinson planted late), resulting in less effect of fungicide management than in the other two locations (Ashland Bottoms and Hutchinson planted in the optimal timing). Although there were some similarities, the ranking of the highest yielding varieties was not uniform across locations. Our preliminary data suggest that the application of fungicide to winter wheat in Kansas might be advantageous, but the degree of this benefit will depend upon the environment and on the variety

Nonlocal correlations in iron pnictides and chalcogenides

Deviations of low-energy electronic structurse of iron-based superconductors from density-functional-theory predictions have been parametrized in terms of band- and orbital-dependent mass renormalizations and energy shifts. The former have typically been described in terms of a local self-energy within the framework of dynamical mean field theory, while the latter appears to require nonlocal effects due to interband scattering. By calculating the renormalized band structure in both random phase approximation (RPA) and the two-particle self-consistent approximation (TPSC), we show that correlations in pnictide systems like LaFeAsO and LiFeAs can be described rather well by a nonlocal self-energy. In particular, Fermi pocket shrinkage as seen in experiments occurs due to repulsive interband finite-energy scattering. For the canonical iron chalcogenide system FeSe in its bulk tetragonal phase, the situation is, however, more complex since even including momentum-dependent band renormalizations cannot explain experimental findings. We propose that the nearest-neighbor Coulomb interaction may play an important role in band-structure renormalization in FeSe. We further compare our evaluations of nonlocal quasiparticle scattering lifetime within RPA and TPSC with experimental data for LiFeAs

Comparative oncology: The paradigmatic example of canine and human mast cell neoplasms

In humans, advanced mast cell (MC) neoplasms are rare malignancies with a poor prognosis. Only a few preclinical models are available, and current treatment options are limited. In dogs, MC neoplasms are the most frequent malignant skin tumours. Unlike low-grade MC neoplasms, high-grade MC disorders usually have a poor prognosis with short survival. In both species, neoplastic MCs display activating KIT mutations, which are considered to contribute to disease evolution. Therefore, tyrosine kinase inhibitors against KIT have been developed. Unfortunately, clinical responses are unpredictable and often transient, which remains a clinical challenge in both species. Therefore, current efforts focus on the development of new improved treatment strategies. The field of comparative oncology may assist in these efforts and accelerate human and canine research regarding diagnosis, prognostication, and novel therapies. In this article, we review the current status of comparative oncology approaches and perspectives in the field of MC neoplasms

Comparative analysis of IL6 and IL6 receptor gene polymorphisms in mastocytosis

Mastocytosis is a rare disease with reported high interleukin-6 (IL6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode IL6 and its receptor (IL6R) in relation to mastocytosis development in a case-control design. Analysis of the IL6R Asp358Ala polymorphism showed that carriers of the AA genotype had a 2.5-fold lower risk for mastocytosis than those with the AC or CC genotypes. No association with mastocytosis was found for the IL6-174G/C polymorphism, however, it may influence the effect of IL6R polymorphism. To the best of our knowledge this is the first study analysing IL6/IL6R polymorphisms in mastocytosis