Precision spray modeling using image processing and artificial neural network

This study employed artificial neural network method for predicting the sprayer drift under different conditions using image processing technique. A wind tunnel was used for providing air flow in different velocities. Water Sensitive Paper (WSP) was used to absorb spray droplets and an automatic algorithm processed the images of WSPs for measuring droplet properties including volume median diameter (Dv0.5) and Surface Coverage Percent (SCP). Four Levenberg-Marqurdt models were developed to correlate the sprayer drift (output parameter) to the input parameters (height, pressure, wind velocity and Dv0.5). The ANN models were capable of predicting the output variables in different conditions of spraying with a high performance. Both models predicted the output variables with R2 values higher than 0.96 indicating the accuracy of the selected networks. Therefore, the developed predictor models can be used in precision agriculture for decreasing spray costs and losses and also environmental contamination

Design, construction and evaluation of a sprayer drift measurement system

Spray drift study for reducing environmental hazards and protecting crops is of high importance as the pesticides used today are more active and many are non-selective. Drift potential can be restricted by assessing and optimizing equipment design, application parameters, the liquid spray properties, type of formulation and environmental conditions. The aim of this research was to design, construct and assess an intelligent system to determine the level of the spraying drift. The main parts of the system were liquid supply mechanism, pipes and nozzles, a controlled pneumatic system to pressurize the liquid, a nozzle moving system with a controlling panel and a tunnel for wind providing and control. To assess the performance of sprayer and drift of droplets, water sensitive papers were placed in different distances from the nozzle considering different environmental conditions including: wind speed, spraying pressure and height. The evaluation results showed that the drift was increased with increasing of sparing pressure and nozzle height.

Recent Advances on Nanotechnology-Based Strategies for Prevention, Diagnosis, and Treatment of Coronavirus Infections

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is exponentially spreading across the world, leading to an outbreak of serious viral pneumonia. Antiviral therapies using chloroquine, hydroxychloroquine, and favipiravir have been approved by several countries to increase the quality of life of SARS-CoV-2-infected patients. Currently, several companies are intensively working on the production of coronavirus (CoV) vaccines, resulting in some specific vaccines that have been approved for CoV infections in humans. Nevertheless, efficient and specific prevention, treatment, and diagnosis are urgently required to combat the biological diversity and rapid mutation in CoV infections. Recently, significant attention has devoted to nanoformulation or nanoparticles (NPs) due to their specific features like high surface-to-volume ratio, drug encapsulation abilities, and specific optical properties to remove the complications of applied conventional therapeutic and diagnosis options. In this regard, NPs are increasingly used as new anti-CoV agents, vaccine carriers or adjuvants, and nanoscale biorecognition elements. The present review article provides a comprehensive discussion on the recent updates regarding the prevention, diagnosis, and treatment of different CoV infections with an emphasis on the application of NPs in vaccination, treatment, and diagnosis of CoV infections

Graphene Family Nanomaterials in Ocular Applications

Publisher Copyright: ©Graphene family nanomaterials (GFNs) are rapidly emerging for ocular applications due to their outstanding physicochemical properties. Since the eyes are very sensitive organs and the contact between the eyes and GFNs in eye drops, contact lenses, intraocular drug delivery systems and biosensors and even the workers handling these nanomaterials is inevitable, it is necessary to investigate their ocular toxicities and physiological interactions with cells as well as their toxicity mechanisms. The toxicity of GFNs can be extremely affected by their physicochemical properties, including composition, size, surface chemistry, and oxidation level as well as dose and the time of exposure. Up to now, there are several studies on the in vitro and in vivo toxicity of GFNs; however, a comprehensive review on ocular toxicity and applications of GFNs is missing, and a knowledge about the health risks of eye exposure to the GFNs is predominantly unspecified. This review highlights the ocular applications of GFNs and systematically covers the most recent advances of GFNs' physicochemical properties, in vitro and in vivo ocular toxicity, and the possible toxicity mechanisms as well as provides some perspectives on the potential risks of GFNs in material development and biomedical applications.Peer reviewe

Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines