Nuevas inscripciones de época romana procedentes de la Era del Moro (León)

Set of six Roman tombstones found in the wall of Leon in June-July 2020.Se dan a conocer un conjunto de seis lápidas romanas aparecidas en la Muralla de León en junio-julio de 2020

Overview of processing techniques for surface electromyography signals

Surface electromyography (sEMG) is a technology to assess muscle activation, which is an important component in applications related to diagnosis, treatment, progression assessment, and rehabilitation of specific individuals' conditions. Recently, sEMG potential has been shown, since it can be used in a non-invasive manner; nevertheless, it requires careful signal analysis to support health professionals reliably. This paper briefly described the basic concepts involved in the sEMG, such as the physiology of the muscles, the data acquisition, the signal processing techniques, and classification methods that may be used to identify disorders or signs of abnormalities according to muscular patterns. Specifically, classification methods encompass digital signal processing techniques and machine learning with high potential in the field. We hope that this work serves as an introduction to researchers interested in this field.Comment: 11 pages, 7 figure

Técnicas de electrónica de potencia para el electroaturdimiento y electrosacrificio, en el sector del atún rojo

Las técnicas de electropesca utilizadas en agua dulce han sido adaptadas a la explotación industrial de la pesca en agua salada de especies como el atún rojo. Por desgracia, como consecuencia de las descargas eléctricas aplicadas, a través de un arpón, se producen daños en la espina que disminuyen la calidad del producto. Se describe aquí un proyecto que aborda el desarrollo de un convertidor electrónico de potencia, versátil y que permite estudiar diferentes formas de onda y su efecto sobre la calidad del producto.Ginés Méndez España S.L

Preliminary trials on the development of electroslaughtering and electrostunning techniques for bluefin tuna Thunnus thynnus (L., 1758) reared in floating cages

Preliminary results are presented from an ongoing study concerning the relationship between the type of electrical waves used to slaughter bluefin tuna Thunnus thynnus (L., 1758) ongrown in floating cages, and damage to the dorsal column and fish meat, which reduces the fish's commercial value on the Japanese market. Our results indicate that varying the waves' characteristics can reduce those undesirable effects, making this technique the most suitable for bluefin tuna slaughtering, in order to obtain superior meat quality.Se presentan los resultados preliminares del estudio que se lleva a cabo sobre la relación existente entre el tipo de onda eléctrica utilizada para el electrosacrificio del atún rojo Thunnus thynnus (L., 1758), engordado en jaulas flotantes, y los daños producidos en la espina dorsal y la carne de los ejemplares de esta especie, que reducen su valor comercial en el mercado japonés. Se ha observado que se puede mitigar estos efectos indeseados variando las características de las ondas empleadas, haciendo de esta técnica la más apropiada en el sacrificio del atún para obtener una carne de calidad superior.Instituto Español de OceanografíaVersión del editor

A deep learning system for detection of early Barrett's neoplasia:a model development and validation study

BACKGROUND: Computer-aided detection (CADe) systems could assist endoscopists in detecting early neoplasia in Barrett's oesophagus, which could be difficult to detect in endoscopic images. The aim of this study was to develop, test, and benchmark a CADe system for early neoplasia in Barrett's oesophagus.METHODS: The CADe system was first pretrained with ImageNet followed by domain-specific pretraining with GastroNet. We trained the CADe system on a dataset of 14 046 images (2506 patients) of confirmed Barrett's oesophagus neoplasia and non-dysplastic Barrett's oesophagus from 15 centres. Neoplasia was delineated by 14 Barrett's oesophagus experts for all datasets. We tested the performance of the CADe system on two independent test sets. The all-comers test set comprised 327 (73 patients) non-dysplastic Barrett's oesophagus images, 82 (46 patients) neoplastic images, 180 (66 of the same patients) non-dysplastic Barrett's oesophagus videos, and 71 (45 of the same patients) neoplastic videos. The benchmarking test set comprised 100 (50 patients) neoplastic images, 300 (125 patients) non-dysplastic images, 47 (47 of the same patients) neoplastic videos, and 141 (82 of the same patients) non-dysplastic videos, and was enriched with subtle neoplasia cases. The benchmarking test set was evaluated by 112 endoscopists from six countries (first without CADe and, after 6 weeks, with CADe) and by 28 external international Barrett's oesophagus experts. The primary outcome was the sensitivity of Barrett's neoplasia detection by general endoscopists without CADe assistance versus with CADe assistance on the benchmarking test set. We compared sensitivity using a mixed-effects logistic regression model with conditional odds ratios (ORs; likelihood profile 95% CIs).FINDINGS: Sensitivity for neoplasia detection among endoscopists increased from 74% to 88% with CADe assistance (OR 2·04; 95% CI 1·73-2·42; p&lt;0·0001 for images and from 67% to 79% [2·35; 1·90-2·94; p&lt;0·0001] for video) without compromising specificity (from 89% to 90% [1·07; 0·96-1·19; p=0·20] for images and from 96% to 94% [0·94; 0·79-1·11; ] for video; p=0·46). In the all-comers test set, CADe detected neoplastic lesions in 95% (88-98) of images and 97% (90-99) of videos. In the benchmarking test set, the CADe system was superior to endoscopists in detecting neoplasia (90% vs 74% [OR 3·75; 95% CI 1·93-8·05; p=0·0002] for images and 91% vs 67% [11·68; 3·85-47·53; p&lt;0·0001] for video) and non-inferior to Barrett's oesophagus experts (90% vs 87% [OR 1·74; 95% CI 0·83-3·65] for images and 91% vs 86% [2·94; 0·99-11·40] for video).INTERPRETATION: CADe outperformed endoscopists in detecting Barrett's oesophagus neoplasia and, when used as an assistive tool, it improved their detection rate. CADe detected virtually all neoplasia in a test set of consecutive cases.FUNDING: Olympus.</p

Efficient Matrix-Element Matching with Sector Showers

A Markovian shower algorithm based on "sector antennae" is presented and its main properties illustrated. Tree-level full-color matrix elements can be automatically incorporated in the algorithm and are re-interpreted as process-dependent 2 -> n antenna functions. In hard parts of phase-space, these functions generate tree-level matrix-element corrections to the shower. In soft parts, they should improve the logarithmic accuracy of it. The number of matrix-element evaluations required per order of matching is 1, with an unweighting efficiency that remains very high for arbitrary numbers of legs. Total rates can be augmented to NLO precision in a straightforward way. As a proof of concept, we present an implementation in the publicly available VINCIA plug-in to the PYTHIA 8 event generator, for hadronic $Z^0$ decays including tree-level matrix elements through ${\cal O}(\alpha_s^4)$.Comment: 35 pages, 24 figure

Importance of Post-Translational Modifications for Functionality of a Chloroplast-Localized Carbonic Anhydrase (CAH1) in Arabidopsis thaliana

Background: The Arabidopsis CAH1 alpha-type carbonic anhydrase is one of the few plant proteins known to be targeted to the chloroplast through the secretory pathway. CAH1 is post-translationally modified at several residues by the attachment of N-glycans, resulting in a mature protein harbouring complex-type glycans. The reason of why trafficking through this non-canonical pathway is beneficial for certain chloroplast resident proteins is not yet known. Therefore, to elucidate the significance of glycosylation in trafficking and the effect of glycosylation on the stability and function of the protein, epitope-labelled wild type and mutated versions of CAH1 were expressed in plant cells. Methodology/Principal Findings: Transient expression of mutant CAH1 with disrupted glycosylation sites showed that the protein harbours four, or in certain cases five, N-glycans. While the wild type protein trafficked through the secretory pathway to the chloroplast, the non-glycosylated protein formed aggregates and associated with the ER chaperone BiP, indicating that glycosylation of CAH1 facilitates folding and ER-export. Using cysteine mutants we also assessed the role of disulphide bridge formation in the folding and stability of CAH1. We found that a disulphide bridge between cysteines at positions 27 and 191 in the mature protein was required for correct folding of the protein. Using a mass spectrometric approach we were able to measure the enzymatic activity of CAH1 protein. Under circumstances where protein N-glycosylation is blocked in vivo, the activity of CAH1 is completely inhibited. Conclusions/Significance: We show for the first time the importance of post-translational modifications such as N-glycosylation and intramolecular disulphide bridge formation in folding and trafficking of a protein from the secretory pathway to the chloroplast in higher plants. Requirements for these post-translational modifications for a fully functional native protein explain the need for an alternative route to the chloroplast.This work was supported by the Swedish Research Council (VR), the Kempe Foundations and Carl Tryggers Foundation to GS, and grant numbers BIO2006-08946 and BIO2009-11340 from the Spanish Ministerio de Ciencia e Innovación (MICINN) to A

Cognitive behaviour therapy response and dropout rate across purging and nonpurging bulimia nervosa and binge eating disorder : DSM-5 implications

Background: With the imminent publication of the new edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), there has been a growing interest in the study of the boundaries across the three bulimic spectrum syndromes [bulimia nervosa-purging type (BN-P), bulimia nervosa-non purging type (BN-NP) and binge eating disorder (BED)]. Therefore, the aims of this study were to determine differences in treatment response and dropout rates following Cognitive Behavioural Therapy (CBT) across the three bulimic-spectrum syndromes. Method: The sample comprised of 454 females (87 BED, 327 BN-P and 40 BN-NP) diagnosed according to DSM-IV-TR criteria who were treated with 22 weekly outpatient sessions of group CBT therapy. Patients were assessed before and after treatment using a food and binging/purging diary and some clinical questionnaires in the field of ED. "Full remission" was defined as total absence of binging and purging (laxatives and/or vomiting) behaviors and psychological improvement for at least 4 (consecutive). Results: Full remission rate was found to be significantly higher in BED (69.5%) than in both BN-P (p < 0.005) and BN-NP (p < 0.001), which presented no significant differences between them (30.9% and 35.5%). The rate of dropout from group CBT was also higher in BED (33.7%) than in BN-P (p < 0.001) and BN-NP (p < 0.05), which were similar (15.4% and 12.8%, respectively). Conclusions: Results suggest that purging and non-purging BN have similar treatment response and dropping out rates, whereas BED appears as a separate diagnosis with better outcome for those who complete treatment. The results support the proposed new DSM-5 classification