Marine 5-thiohistidines as protective molecules from skin damage

Introduction Marine environment is a great source of bioactive molecules, whose biological properties and applications are often used especially to prevent skin diseases and aging caused by UVA­exposure. Ovothiols are methyl­5­thiohistidines from marine invertebrates, bacteria, and microalgae, which protect cells from environmental stressors. Recently, we have shown that, ovothiol, isolated from sea urchin eggs, exerts anti­inflammatory and antioxidant activities on human endothelial cells, and exhibits antifibrotic effect in an in vivo model of liver fibrosis.info:eu-repo/semantics/publishedVersio

Numerical solution of linear models in economics: The SP-DG model revisited

In general, complex and large dimensional models are needed to solve real economic problems. Due to these characteristics, there is either no analytical solution for them or they are not attainable. As a result, solutions can be only obtained through numerical methods. Thus, the growing importance of computers in Economics is not surprising. This paper focuses on an implementation of the SP-DG model, using Matlab,developed by the students as part of the Computational Economics course. We also discuss some of our teaching/learning experience within the course, given for the first time in the FEP Doctoral Programme in Economics.SP-DG Model, Output, Inflation, Numerical Simulation, Teaching of Economics

A Multi-Cloud Warm-Absorber Model for NGC 4051

A multi-cloud model is presented which explains the soft X-ray excess in NGC 4051 and, consistently, the optical line spectrum and the SED of the continuum. The clouds are heated and ionized by the photoionizing flux from the active center and by shocks. Diffuse radiation, partly absorbed throughout the clouds, nicely fits the bump in the soft X-ray domain, while bremsstrahlung radiation from the gaseous clouds contribute to the fit of the continuum SED. Debris of high density fragmented clouds are necessary to explain the absorption oxygen throats observed at 0.87 keV and 0.74 keV. The debris are heated by shocks of about 200-300 km/s. Low velocity (100 km/s)-density (100 cm-3) clouds contribute to the line and continuum spectra, as well as high velocity (1000 km/s)-density (8000 cm-3) clouds which are revealed by the FWHM of the line profiles. The SED in the IR is explained by reradiation of dust, however, the dust-to-gas ratio is not particularly high. Radio emission is well fitted by synchrotron radiation created at the shock front by Fermi mechanism.Comment: 19 pages + 3 figures PostScrip

Study of latencies in ThingSpeak

IoT platforms play an important role on modern measurement systems because they allow the ingestion and processing of huge amounts of data (big data). Given the increasing use of these platforms, it is important to characterize their performance and robustness in real application scenarios. The paper analyzes the ThingSpeak platform by measuring the latencies associated to data packets sent to cloud and replied back, and by checking the consistency of the returned data. Several experiments were done considering different ways to access the platform: REST API, MQTT API, and MQTT broker alone. For each experiment, the methodology is explained, results are presented, and conclusions are extracted. The REST and MQTT APIs have similar performances, with roundtrip times between 1 s and 3 s. The MQTT broker alone is more agile, with roundtrip times below 250 ms. In all cases, the up and down links are far from being symmetric, with the uplink delay showing higher variance than the downlink delay. The obtained results can serve as a reference for other IoT platforms and provide guidelines for application development.info:eu-repo/semantics/publishedVersio

Examining the relationship between sugar content, packaging features, and food claims of breakfast cereals

Excessive free-sugar intake has become highly prevalent in numerous countries, and Portugal is not the exception. One product category that contributes to the daily intake of free sugars is breakfast cereals. In the current work, we identified 289 exemplars from two major retailers in Portugal and collected information on their nutritional profile (e.g., sugar, salt, fiber per 100 g), price, packaging features, type of food claims present (e.g., statements about the composition, sensory features, the origin of the product), and ingredients list. Overall, the sugar content of breakfast cereals was high (Mean = 19.9 g), and less than 10% of the products complied with the current national guidelines (i.e., 5 g of sugar per 100 g of product). Sugar (or other sugar sources) was listed in the top three ingredients for over 85% of the products. On average, each product included about four claims (Mean = 3.9), and sugar content was lower when the claims were related to the product composition. Critically, the sugar content was particularly high for children-oriented products (Mean = 26.4 g). Correlation analysis showed that breakfast cereals with higher sugar content also were cheaper and had lower quantities of fiber, proteins, and salt. Our findings suggest the need to implement strategies to reduce sugar in this product category (e.g., incentivize manufacturers to reformulate products). Also, our results may inform strategies aimed at promoting consumers’ awareness about the sugar content in breakfast cereals and other processed foods, facilitating healthier decision-making.info:eu-repo/semantics/publishedVersio

Evidence for a Physically Compact Narrow-Line Region in the Seyfert 1 Galaxy NGC 5548

We have combined HST/FOS and ground-based spectra of the Seyfert 1 galaxy NGC 5548 to study the narrow emission lines over the 1200 -- 10,000 angstrom region. All of the spectra were obtained when the broad emission line and continuum fluxes were at an historic low level, allowing us to accurately determine the contribution of the narrow-line region (NLR) to the emission lines. We have generated multicomponent photoionization models to investigate the relative strength of the high ionization lines compared to those in Seyfert 2 galaxies, and the weakness of the narrow Mg II 2800 line. We present evidence for a high ionization component of NLR gas that is very close to the nucleus (~1 pc). This component must be optically thin to ionizing radiation at the Lyman edge (tau = 2.5) to avoid producing [O I] and Mg II in a partially ionized zone. The very high ionization lines (N V, [Ne V], [Fe VII], [Fe X]) are stronger than the predictions of our standard model, and we show that this may be due to supersolar abundances and/or a ``blue bump'' in the extreme ultraviolet (although recent observations do not support the latter). An outer component of NLR gas (at only ~70 pc from the continuum source) is needed to produce the low ionization lines. We show that the outer component may contain dust, which further reduces the Mg II flux by depletion and by absorption of the resonance photons after multiple scatterings. We show that the majority of the emission in the NLR of NGC 5548 must arise within about ~70 pc from the nucleus. Thus, the NLR in this Seyfert 1 galaxy is very physically compact, compared to the typical NLR in Seyfert 2 galaxies.Comment: 38 pages, Latex, includes 2 figures (postscript), to appear in Ap

Infrared FeII Emission in Narrow-Line Seyfert 1 Galaxies

We obtained 0.8-2.4 micron spectra at a resolution of 320 km/s of four narrow-line Seyfert 1 galaxies in order to study the near-infrared properties of these objects. We focus on the analysis of the FeII emission in that region and the kinematics of the low-ionization broad lines. We found that the 1 micron FeII lines (9997 A, 10501 A, 10863 A and 11126 A) are the strongest FeII lines in the observed interval. For the first time, primary cascade lines of FeII arising from the decay of upper levels pumped by Ly-alpha fluorescence are resolved and identified in active galactic nuclei. Excitation mechanisms leading to the emission of the 1 micron FeII features are discussed. A combination of Ly-alpha fluorescence and collisional excitation are found to be the main contributors. The flux ratio between near-IR FeII lines varies from object to object, in contrast to what is observed in the optical region. A good correlation between the 1 micron and optical FeII emission is found. This suggests that the upper z4Fo and z4Do levels from which the bulk of the optical lines descend are mainly populated by the transitions leading to the 1 micron lines. The width and profile shape of FeII 11127, CaII 8642 and OI 8446 are very similar but significantly narrower than Pa-beta, giving strong observational support to the hypothesis that the region where FeII, CaII and OI are produced are co-spatial, interrelated kinematically and most probably located in the outermost portion of the BLR.Comment: Accepted for publication in ApJ - 35 page

Risk assessment of exposure to multiple mycotoxins in the Icelandic population

Background: The proliferation of mycotoxin-producing fungi in agricultural settings poses a challenge to human health and nutrition around the world. Mycotoxins contaminate food sources and their negative health outcomes include carcinogenic, nephrotoxic, and teratogenic effects. Potential risks are still poorly characterized and few studies assess exposure at an individual level. Thus, the goal of this study was to assess and characterize exposure risk to multiple mycotoxins in the Icelandic population. Methods: Urine samples and data on urinary mycotoxin biomarkers (deoxynivalenol, zearalenone, and ochratoxin A) from a pool of 171 individuals living in Iceland between 2020 and 2021 were used to estimate external doses through reverse dosimetry. For risk characterization, Hazard Quotient (HQ) and Margin of Exposure (MoE) approaches were applied for deoxynivalenol zearalenone, and ochratoxin A, respectively. Results: The Icelandic population was revealed to be exposed to multiple mycotoxins. Mean levels of deoxynivalenol and ochratoxin A were comparable to what have been reported in other European studies, while levels of zearalenone were considerably lower. Nevertheless, risk assessment revealed safe levels of exposure to deoxynivalenol and zearalenone (HQ < 1) but MoE based on a neoplastic endpoint to ochratoxin A indicated a possible health concern for all participants (MoE < 10000). Conclusions: Although there are some uncertainties associated with a human biomonitoring approach, the results of this study confirm that mycotoxins are a growing threat to public health in the European continent. Since countries with different latitudes already present comparable levels of exposure, this is especially concerning in a climate change scenario. Further studies both on exposure assessment and specific effects on human health are required to accurately assess risk and introduce preventive measures.info:eu-repo/semantics/publishedVersio

The optical-ultraviolet continuum of Seyfert 2 galaxies

This paper aims to understand the continuum of Seyfert 2 galaxies. By fitting the single galaxies in the sample of Heckman et al. (1995) with composite models (shock+ photoionization from the active center), we show that five main components characterize the SED of the continuum. Shocks play an important role since they produce a high temperature zone where soft X-rays are emitted. We show that in the optical-UV range, the slope of the NLR emission reproduces the observed values, and may be the main component of the featureless continuum. The presence of star forming regions cannot be excluded in the circumnuclear region of various Seyfert galaxies. An attempt is made to find their fingerprints in the observed AGN spectra. Finally, it is demonstrated that multi-cloud models are necessary to interpret the spectra of single objects, even in the global investigation of a sample of galaxies.Comment: 26 pages, LaTeX (including 5 Tables) + 17 PostScript figures. To appear in "The Astrophysical Journal

On ionisation effects and abundance ratios in damped Lyman-alpha systems

The similarity between observed velocity structures of Al III and singly ionised species in damped Lyman-alpha systems (DLAs) suggests the presence of ionised gas in the regions where most metal absorption lines are formed. To explore the possible implications of ionisation effects we construct a simplified two-region model for DLAs consisting of an ionisation bounded region with an internal radiation field and a neutral region with a lower metal content. Within this framework we find that ionisation effects are important. If taken into account, the element abundance ratios in DLAs are quite consistent with those observed in Milky Way stars and in metal-poor H II regions in blue compact dwarf galaxies. In particular we cannot exclude the same primary N origin in both DLAs and metal-poor galaxies. From our models no dust depletion of heavy elements needs to be invoked; little depletion is however not excluded.Comment: to appear in "Evolution of Galaxies. I. Observational clues", Eds. J.M. Vilchez, G. Stasinska, Astrophysics and Space Science, in press. 5 pages, including 3 figure