Three-Dimensional Limit Analysis of the Vicoforte Elliptical Dome

Limit Analysis provides a conceptually simple and robust method to estimate the safety of structures and has been long applied to the analysis of the ultimate collapse state of two-dimensional masonry structures or structural elements. In revolving symmetric domes, the three-dimensional problem can be reduced to the two-dimensional case under appropriate hypotheses. The Vicoforte dome is the largest elliptical dome in the world, and its complex geometry makes this kind of analysis not straightforward. Starting from some basic assumptions, a method for analyzing the three-dimensional elliptical geometry and understand the behavior at collapse of the drum-dome system using limit analysis is proposed. The three dimensional collapse mechanism is found and the system behavior including the presence of tension rings at different levels is interpreted. The results are compared against a nonlinear finite element model

INTRABEAM: precision hypo-fractionated radiotherapy with a systemic immune response

Purpose or Objective: To evaluate the changes in immune-cell phenotype in peripheral blood following intraoperative radiotherapy (IORT) in breast cancer patients

Spectral properties of the one-dimensional two-channel Kondo lattice model

We have studied the energy spectrum of a one-dimensional Kondo lattice, where the localized magnetic moments have SU(N) symmetry and two channels of conduction electrons are present. At half filling, the system is shown to exist in two phases: one dominated by RKKY-exchange interaction effects, and the other by Kondo screening. A quantum phase transition point separates these two regimes at temperature $T = 0$. The Kondo-dominated phase is shown to possess soft modes, with spectral gaps much smaller than the Kondo temperature.Comment: 4 pages + 2 figures. Submitted for publicatio

First order transition and phase separation in pyrochlores with colossal-magnetoresistance

Tl$_{2}$Mn$_{2}$O$_{7}$ pyrochlores present colossal magnetoresistance (CMR) around the long range ferromagnetic ordering temperature (T$_{C}$). The character of this magnetic phase transition has been determined to be first order, by purely magnetic methods, in contrast to the second order character previously reported by Zhao et al. (Phys. Rev. Lett. 83, 219 (1999)). The highest CMR effect, as in Tl$_{1.8}$Cd$_{0.2}$Mn$_{2}$O$_{7}$, corresponds to a stronger first order character. This character implies a second type of magnetic interaction, besides the direct superexchange between the Mn$^{4+}$ ions, as well as a phase coexistence. A model is proposed, with a complete Hamiltonian (including superexchange and an indirect interaction), which reproduce the observed phenomenology.Comment: 6 pages. Figures include

Study of encapsulation parameters to improve content of lycopene in tomato (Solanum lycopersicum L.) powders

The aim was to examine conditions of convective drying and spray-drying to improve preservation of lycopene content in tomatoes. The weight, size, colour, pH and °Brix values were evaluated in fresh fruit (FF) and colour (L, a, b), hue, and chrome indices were analysed from dried tomatoes, too. Tomato paste was dried (40, 50, 60, and 80 °C with times of 540, 390, 270, and 240 min) under convection conditions and pulverized. In the encapsulation treatments core material with tomato powders of 50, 60, and 70%, shell solution of maltodextrin/gum arabic 1:1, flow rate of 4, 6, 9, and 12 ml min–1, and inlet air T of 160, 170, and 180 °C were used. The physicochemical properties of FF corresponded to a degree of ripeness for consumption. The a, a/b, and hue values of dried tomatoes at 50 °C significantly correlated to red colouring and higher lycopene content (47.98±1.49 mg/100 g). The encapsulation with 50% and 60% of tomato powders, 170 °C and 9 ml min–1 treatments increased lycopene contents to 10.41 mg/100 g, 10.20 mg/100 g, and 11.51 mg/100 g, respectively. The results demonstrated that the physicochemical and functional properties were influenced by drying conditions, providing useful information for increasing the stability of lycopene in dried tomatoes

Polyphenols journey through blood-brain barrier towards neuronal protection

Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases.info:eu-repo/semantics/publishedVersio

Origin and pressure dependence of ferromagnetism in A2Mn2O7 pyrochlores (A=Y, In, Lu, and Tl)

Non-conventional mechanisms have been recently invoked in order to explain the ferromagnetic ground state of A2Mn2O7 pyrochlores (A=Y, In, Lu and Tl) and the puzzling decrease of their Curie temperatures with applied pressure. Here we show, using a perturbation expansion in the Mn-O hopping term, that both features can be understood within the superexhange model, provided that the intra-atomic oxygen interactions are properly taken into account. An additional coupling between the Mn ions mediated by the In(5s)/Tl(6s) bands yields the higher Tc's of these two compounds, this mechamism enhancing their ferromagnetism for higher pressures.Comment: 7 pages and 2 figures submitted to Phys. Rev. B, missing text adde

Preanalytical issues related to routine and diagnostic glucose tests: Results from a survey in Spain

Introduction: Diabetes mellitus (DM) is one of the most prevalent diseases worldwide. The objective of this study was to find out under what preanalytical conditions routine and diagnostic glucose tests are performed across Spanish laboratories; and also what criteria are used for DM diagnosis. Materials and methods: An online survey was performed by the Commission on Quality Assurance in the Extra-Analytical Phase of the Spanish Society of Laboratory Medicine (SEQC-ML). Access to the questionnaire was available on the home page of the SEQC-ML website during the period April-July 2018. Data analysis was conducted with the IBM SPSS© Statistics (version 20.0) program. Results: A total of 96 valid surveys were obtained. Most laboratories were in public ownership, serving hospital and primary care patients, with high and medium workloads, and a predominance of mixed routine-urgent glucose testing. Serum tubes were the most used for routine glucose analysis (92%) and DM diagnosis (54%); followed by lithium-heparin plasma tubes (62%), intended primarily for urgent glucose testing; point-ofcare testing devices were used by 37%; and plasma tubes with a glycolysis inhibitor, mainly sodium fluoride, by 19%. Laboratories used the cut-off values and criteria recognized worldwide for DM diagnosis in adults and glucose-impaired tolerance, but diverged in terms of fasting plasma glucose and gestational DM criteria. Conclusion: Preanalytical processing of routine and DM diagnostic glucose testing in Spain does not allow a significant, non-quantified influence of glycolysis on the results to be ruled out. Possible adverse consequences include a delay in diagnosis and possible under-treatmen

Gender differences in the incidence of and risk factors for hip fracture: A 16-year longitudinal study in a southern European population

Objectives To analyze independently in men and women the incidence rate of and risk factors for hip fracture in a southern European population. Illiteracy, dementia, clinically significant depression and disability were factors to receive special emphasis. Study design A community sample of 4803 individuals aged over 55 years was assessed in a two-phase case-finding study in Zaragoza, Spain, and was followed up for 16 years. Medical history and psychiatric history were collected with standardized instruments, including the History and Aetiology Schedule, the Geriatric Mental State (GMS) scale, and a Risk Factors Questionnaire. Operational criteria were used to define covariates, including diagnostic criteria for both dementia and depression. The statistical analysis included calculations of incidence rate, IR; women/men incidence rate ratio (IRR); and Hazard Ratios (HR) in multivariate Cox proportional hazards regression models. Main outcome measures Cases of hip fracture (International Classification of Diseases, WHO) identified in the treating hospitals, validated by blinded researchers. Results Hip fractures were more frequent among women than men (IRR = 3.1). Illiteracy (HR = 1.55) and depression (HR = 1.44) increased the risk in women, and smoking (HR = 2.13) and disability in basic activities of daily living (HR = 3.14) increased the risk in men. Dementia was associated with an increased risk in an univariate analysis, but the association disappeared (power = 85% in men, 95% in women) when disability was included in the multivariate models. Conclusions The IR of hip fractures was three times higher among women. Illiteracy and clinically significant depression among women and active smoking and disability (HR = 3.14) among men independently increased the risk, but dementia did not