Age-related complications such as neurodegenerative disorders are increasing and remain cureless.
The possibility of altering the progression or the development of these multifactorial diseases through
diet is an emerging and attractive approach with increasing experimental support. We examined
the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to
infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies
across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for
diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these
phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies.
Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and
infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of
NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary
(poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and
exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases.info:eu-repo/semantics/publishedVersio