The complex impact structure Serra da Cangalha, Tocantins State, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Serra da Cangalha is a complex impact structure with a crater diameter of 13,700 m and a central uplift diameter of 5800 m. New findings of shatter cones, planar fractures, feather features, and possible planar deformation features are presented. Several ring-like features that are visible on remote sensing imagery are caused by selective erosion of tilted strata. The target at Serra da Cangalha is composed of Devonian to Permian sedimentary rocks, mainly sandstones that are interlayered with siltstone and claystones. NNE-SSW and WNW-ESE-striking joint sets were present prior to the impact and also overprinted the structure after its formation. As preferred zones of weakness, these joint sets partly controlled the shape of the outer perimeter of the structure and, in particular, affected the deformation within the central uplift. Joints in radial orientation to the impact center did not undergo a change in orientation during tilting of strata when the central uplift was formed. These planes were used as major displacement zones. The asymmetry of the central uplift, with preferred overturning of strata in the northern to western sector, may suggest a moderately oblique impact from a southerly direction. Buckle folding of tilted strata, as well as strata overturning, indicates that the central uplift became gravitationally unstable at the end of crater formation.466875889German Research Foundation (DFG) [Re 528/9-1, Re 528/11-1]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Ph.D. grantGerman Academic Exchange Service (DAAD)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)German Research Foundation (DFG) [Re 528/9-1, Re 528/11-1]FAPESP [2008/53588-7]CNPq [30334/2009-0

X-Disease Game

Os padrões de herança dos distúrbios ligados ao X foram facilmente identificados devido à distribuição desigual do cromossomo X entre mulheres e homens. Como as outras doenças monogênicas, os distúrbios ligados ao X são categorizados em dominantes e recessivos. Para ensinar sobre esse padrão de herança de doenças, foi criado um jogo de memória, cujo principal objetivo foi informar, de forma lúdica, suas características. Este jogo da memória contém 24 cartas, divididas em 12 pares. Cada dupla tem um cartão com texto informativo e outro com figura ilustrativa sobre o texto correspondente. O jogo precisa de dois jogadores que usarão capacidades de memória e lógica. Enquanto o jogo avança, o jogador deve usar a memória para armazenar as informações contidas na carta e sua posição no jogo, vencendo o jogador que atinge um número maior de pares corretos. O jogo da memória mostrou-se eficiente na aquisição de conhecimento sobre o tema, trazido de forma lúdica e fácil de aprender. Ao relacionar as informações contidas nos textos com as imagens, os jogadores apresentaram uma maior compreensão sobre as características das doenças ligadas ao X

That so-called papanicolaou: women's social representations about the screening test for cervical cancer

Esta pesquisa teve como objetivos identificar as representações sociais de mulheres sobre o câncer do colo do útero, e descrever a relação dessas representações sociais para o cuidado preventivo. A abordagem utilizada foi do tipo qualitativo-exploratório, adotando a teoria das representações sociais como suporte teórico-conceitual. Duas técnicas de coleta foram utilizadas para obtenção dos dados: a livre associação de palavras e a entrevista semidirigida com perguntas abertas. Para a interpretação dos dados foi utilizada a técnica de análise temática. A pesquisa teve como resultado duas unidades temáticas: câncer cérvico-uterino - uma ferida tratável e o preventivo - o fazer por temer. Observou-se que as mulheres temem muito o câncer cérvico-uterino e, por esse motivo, admitem a importância da realização do exame preventivo, considerando-o como um ato de cuidado com a própria saúde.Esta investigación tiene como objetivo identificar las identificar las representaciones sociales de mujeres sobre el cáncer del cuello uterino; y describir la relación de esas representaciones sociales para el cuidado preventivo. El abordaje utilizado fue cualitativa - exploratoria, adoptando como soporte teórico conceptual la teoría de las representaciones sociales. Para obtención de los datos se utilizaron tres técnicas de recolección: la asociación libre de palabras, la entrevista semi dirigida con preguntas abiertas y la observación libre. Para la interpretación de esos datos, fue utilizada la técnica de análisis de contenido temático. La investigación tuvo como resultado de las unidades temáticas: cáncer cérvico-uterino: una herida tratable y el preventivo: El hacer por temer. Durante toda la investigación, se observo que las mujeres temen mucho tener cáncer cérvico - uterino, y por ese motivo, admiten la importancia de la realización del examen preventivo y lo consideran como un acto de cuidado con la propia salud.This research aims to identify women's social representations of women regarding cervical cancer and describe the relationship of these social representations with preventive care. The study used a qualitative-exploratory approach, with the theory of social representations as the theoretical-conceptual support. Data collection was performed using two techniques: the free association of words and the semi-directed interview with open questions. The thematic analysis technique was used for data interpretation. The research resulted in two thematic units: cervical cancer: an early treatable wound and the screening test: taking because of fearing. It was observed that women have great fear of having cervical cancer and, therefore, recognize the importance of the screening test and see it as an act of self-care towards their health

Terrestrial impact structures as geoheritage: an assessment method of their scientific value and its application to Brazil

Terrestrial impact structures are geological and geomorphological features with particular importance to understand the history and evolution of the planet. Impact structures are scattered around the world but in many countries these features are under threat, essentially due to anthropic factors. Impact structures with higher scienti c value should be considered as geological heritage and, consequently, be subjected to geoconservation strategies. In order to select the most important impact structures to be properly conserved and managed, this paper proposes a quantitative assessment method of the scienti c value of these structures. The eight Brazilian impact structures were used to test this method that has the potential to be applied to any geological context in any country. The structures known as Araguainha Dome-MT and Serra da Cangalha-TO reached a higher scienti c value, which justi es the need to develop geoconservation strategies and a proper management.The Conselho Nacional de Pesquisa e Desenvolvimento (CNPq / National Council for Research and Development) and the Programa Ciências sem Fronteiras / Science Without Borders Programme are acknowledged for the support of the postdoctoral grant No 233209/2013-1 of the 1st author. The work was co-funded by the European Union through the European Regional Development Fund, based on COMPETE 2020 (Programa Operacional da Competitividade e Internacionalização), project ICT (UID/ GEO/04683/2013) with reference POCI-01-0145- FEDER-007690 and Portuguese funds provided by Fundação para a Ciência e Tecnologia.info:eu-repo/semantics/publishedVersio

Characteristics and outcomes of adult patients in the PETHEMA registry with relapsed or refractory FLT3-ITD mutation-positive acute myeloid leukemia

This retrospective study investigated outcomes of 404 patients with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) acute myeloid leukemia (AML) enrolled in the PETHEMA registry, pre-approval of tyrosine kinase inhibitors. Most patients (63%) had received first-line intensive therapy with 3 + 7. Subsequently, patients received salvage with intensive therapy (n = 261), non-intensive therapy (n = 63) or supportive care only (n = 80). Active salvage therapy (i.e., intensive or non-intensive therapy) resulted in a complete remission (CR) or CR without hematological recovery (CRi) rate of 42%. More patients achieved a CR/CRi with intensive (48%) compared with non-intensive (19%) salvage therapy (p < 0.001). In the overall population, median overall survival (OS) was 5.5 months; 1- and 5-year OS rates were 25% and 7%. OS was significantly (p < 0.001) prolonged with intensive or non-intensive salvage therapy compared with supportive therapy, and in those achieving CR/CRi versus no responders. Of 280 evaluable patients, 61 (22%) had an allogeneic stem-cell transplant after they had achieved CR/CRi. In conclusion, in this large cohort study, salvage treatment approaches for patients with FLT3-ITD mutated R/R AML were heterogeneous. Median OS was poor with both non-intensive and intensive salvage therapy, with best long-term outcomes obtained in patients who achieved CR/CRi and subsequently underwent allogeneic stem-cell transplant.This study was supported by Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Valencia, Spain [CB16/12/00284]

Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls

Objective:: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods:: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results:: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion:: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations

Broker Fixed: The Racialized Social Structure and the Subjugation of Indigenous Populations in the Andes

Responding to calls to return racial analysis to indigenous Latin America, this article moves beyond the prejudicial attitudes of dominant groups to specify how native subordination gets perpetuated as a normal outcome of the organization of society. I argue that a naturalized system of indirect rule racially subordinates native populations through creating the position of mestizo “authoritarian intermediary.” Natives must depend on these cultural brokers for their personhood, while maintaining this privileged position requires facilitating indigenous exploitation. Institutional structures combine with cultural practices to generate a vicious cycle in which increased village intermediary success increases native marginalization. This racialized social structure explains my ethnographic findings that indigenous villagers continued to support the same coterie of mestizos despite their regular and sometimes extreme acts of peculation. My findings about the primacy of race suggest new directions for research into indigenous studies, ethnic mobilizations, and the global dimensions of racial domination

Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis

OBJECTIVE: To report the 10-year follow-up of the MAINTAIN Nephritis Trial comparing azathioprine (AZA) and mycophenolate mofetil (MMF) as maintenance therapy of proliferative lupus nephritis, and to test different definitions of early response as predictors of long-term renal outcome. METHODS: In 2014, data on survival, kidney function, 24 h proteinuria, renal flares and other outcomes were collected for the 105 patients randomised between 2002 and 2006, except in 13 lost to follow-up. RESULTS: Death (2 and 3 in the AZA and MMF groups, respectively) and end-stage renal disease (1 and 3, respectively) were rare events. Time to renal flare (22 and 19 flares in AZA and MMF groups, respectively) did not differ between AZA and MMF patients. Patients with good long-term renal outcome had a much more stringent early decrease of 24 h proteinuria compared with patients with poor outcome. The positive predictive value of a 24 h proteinuria <0.5 g/day at 3 months, 6 months and 12 months for a good long-term renal outcome was excellent (between 89% and 92%). Inclusion of renal function and urinalysis in the early response criteria did not impact the value of early proteinuria decrease as long-term prognostic marker. CONCLUSIONS: The long-term follow-up data of the MAINTAIN Nephritis Trial do not indicate that MMF is superior to AZA as maintenance therapy in a Caucasian population suffering from proliferative lupus nephritis. Moreover, we confirm the excellent positive predictive value of an early proteinuria decrease for long-term renal outcome