IN VITRO ANTIOXIDANT ACTIVITY OF VARIOUS LEAF EXTRACTS OF CANTHIUM COROMANDELICUM(BURM.F.) ALSTON.

Objectives: The objective of this study was to estimate the total phenolic and flavonoid contents and to explore the antioxidant potential of various leaf extracts (chloroform, ethyl acetate, and ethanol) of Canthium coromandelicum, which is considered traditionally as an important medicinal plant.Methods: Antioxidant properties of the extracts were assessed using 1, 1- diphenyl -2- picrylhydrazyl and hydrogen peroxide radical scavenging assays for ascorbic acid equivalents. The total phenolic and flavonoid contents were also investigated to determine their correlation with the antioxidant activity of the leaf extracts and expressed in Gallic acid and quercetin equivalents, respectively.Results: The results showed that the content of total phenols and flavonoids was found to be high in ethyl acetate extract which was recorded as 61.02±1.30 mg Gallic acid equivalent (GAE/g) and 81.72±0.61 QE/g, respectively. Compared to other extracts, ethyl acetate leaf extract was found to possess high antioxidant activity at p<0.05 level, with high percentage of inhibition at 100 μg/ml concentration (82.70%) toward hydrogen peroxide radical scavenging with IC50 value 62.94 μg/ml. Statistically, two-tailed Pearson's correlation showed strong positive correlations between hydrogenperoxide radical scavenging activity and total phenolic contents (TPC) (r=1.000) at p<0.05 level.Conclusion: The results obtained in this study clearly signifies that the ethyl acetate leaf extract of C. coromandelicum has high content of total phenols which are correlated to its antioxidant activity and thus has the potential to use as a source of natural antioxidants and can be explored as a therapeutic agent in free radical induced diseases.Â

The Management of Patient with Oligodontia Associated With Attention Deficit Hyperactive Disorder – A Rare Case Report

Oligodontia is characterized by missing six or more teeth in primary and permanent dentition exclusive of the third molars. Hereditary is the main etiologic factor and the principal clinical features are reduction in number of teeth, changes in the morphology of teeth, their eruption time and improper development of alveolar ridges. Prevalence of Oligodontia is 0.35% in Indian population. Treatment of Oligodontia is through a multidisciplinary approach. Attention Deficit Hyperactive Disorder (ADHD) is the most commonly diag-nosed behavioural disorder of childhood. It is a problem with inattentiveness, over-activity, impulsivity, or a combination. It affects about 3-5% of school aged children. ADHD may run in families, but the etiology is unknown. Depression, lack of sleep, learning disability and behavioural problems may appear with ADHD.The aim of this study was to describe a clinical case of 7 year old child with multiple congenital missing teeth associated with ADHD syndrome. &nbsp

The Binding Number of a Zero Divisor Graph

Abstract In this paper, we evaluate b(Γ(Z n )). Our main result is, we give maximum value of b(Γ(Z n )) is 0.99999999796427626489236243072661, where n is any positive integer upto fiftieth million. Mathematics Subject Classification: 05C25, 05C35, 05C7

Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics

Type II fatty acid synthesis (FAS II) pathway has been recently reported as an attractive targeting for their efficacy against infections caused by multi-resistant Gram-positive and Gram-negative bacteria. Among the related FAS II enzymes, beta ketoacyl-acyl carrier protein synthase (KAS), is an essential target for novel antibacterial drug design. Five novel Ethyl-3-(4-substituted phenyl) propanoates have been synthesized, characterized and screened for antibacterial activity. The inhibitory activities against Escherichia coli b-ketoacyl-acyl carrier protein synthase III (ecKAS III) were investigated by molecular docking simulation. Compounds which posses both good inhibitory activity and well binding affinities were compared their antibacterial activities against gram negative and gram-positive bacterial strains were tested, expecting to exploit potent antibacterial agent with broad-spectrum antibiotics activity. Compounds 4b, 4c, 4d exhibits significant activity and ethyl-3-(4-chlorophenyl)propanaoate (4b) exhibits highest antibacterial activity against all the bacteria among the synthesized compounds.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Nucleation parameters for polymer crystallization from non-isothermal thermal analysis

Differential scanning calorimetry (DSC) has been used to obtain kinetic and nucleation parameters for polymer crystallization under a non-isothermal mode of operation. The available isothermal nucleation growth-rate equation has been modified for non-isothermal kinetic analysis. The values of the nucleation constant (Kg ) and surface free energies (σ, σe) have been obtained for i-polybutene-1, i-polypropylene, poly(L-lactic acid), and polyoxymethylene and are compared with those obtained from isothermal kinetic analysis; a good agreement in both is seen

Crystallization and Melting Behavior of Isotactic Polybutene-1 at High Pressures

An equation has been developed for the study of the kinetics of polymer crystallization at high pressures using differential scanning calorimetry (DSC) in the dynamic mode of operation. The activation energy for the crystallization of isotactic polybutene-1 (PB-1) has been determined to be ca. 20 kcals/mol; this has been attributed to the transport of chain segments to the site of crystallization. The melting behavior of form-I PE-1 crystals has been studied by using a high-pressure differential thermal analyzer (DTA) setup and high-pressure DSC. The melting temperature T, does not show any significant change with pressure in the low pressure region up to 1.2 kbar; beyond this point a large increase in T, with pressure was observed. This unusual low-pressure behavior of PEL1 has been attributed to formation of intermediate form I, which has a lower melting point than form I

CRYSTALLIZATION KINETICS OF POLY(L-LACTIC ACID)

The morphology and crystal growth of poly(l-lactic acid), PLLA have been studied from the melt as a function of undercooling and molecular weight using hot stage microscopy. Attention has been given to the application of growth rate equation on the growth rate data of PLLA and thus various nucleation parameters have been calculated. The criteria of Regime I and Regime II types of crystallization has been applied for the evaluation of substrate lengths

Ferroconvection induced by point heat source

331-337A mathematical model is proposed to study the onset of the free convection in ferrofluid at low Rayleigh number from an instantaneous point heat source. In this work, the leading term of series expansion of the dependent variable in terms of Rayleigh number is considered and is valid in small Rayleigh number regime only. The rate of heat generation is assumed to be not very high, so that Stoke’s flow approximation could be used. The flow field is explained by the streamlines at different times. In the absence of field, the results are compared for the thermal convection due to the instantaneous point heat source