PIXE and ToF-SIMS analysis of streaker samplers filters

This paper presents methodological innovations introduced in the characterisation of urban aerosol collected in Italy in a recent campaign. Two complementary ion beam analysis (IBA) techniques were used to analyse Nuclepore filters used in continuous streaker samplers to collect airborne particles in four Italian towns. Na to Pb elemental concentrations were obtained by particle induced X-ray emission (PIXE), while time of flight secondary ion mass spectrometry (ToF-SIMS) produced, on the same samples, time trends for several elements and molecular fragments. In addition, light attenuation measurements were used as a tracer for black carbon. The data produced by these three techniques was merged into a unique data set to address the characterisation of particulate matter sources. Correlations between elemental concentration trends (PIXE) and relative trends for molecular fragments (ToF-SIMS) and black carbon (light attenuation) have been studied by cluster and principal component analysis

Nitric oxide density distributions in the effluent of an RF argon APPJ: Effect of gas flow rate and substrate

The effluent of an RF argon atmospheric pressure plasma jet, the so-called kinpen, is investigated with focus on the nitric-oxide (NO) distribution for laminar and turbulent flow regimes. An additional dry air gas curtain is applied around the plasma effluent to prevent interaction with the ambient humid air. By means of laser-induced fluorescence (LIF) the absolute spatially resolved NO density is measured as well as the rotational temperature and the air concentration. While in the laminar case, the transport of NO is attributed to thermal diffusion; in the turbulent case, turbulent mixing is responsible for air diffusion. Additionally, measurements with a molecular beam mass-spectrometer (MBMS) absolutely calibrated for NO are performed and compared with the LIF measurements. Discrepancies are explained by the contribution of the NO2 and N2O to the MBMS NO signal. Finally, the effect of a conductive substrate in front of the plasma jet on the spatial distribution of NO and air diffusion is also investigated

Dealing with care disruption in High and Intensive Care wards:From difficult patients to difficult situations

High and Intensive Care is a relatively new care model in Dutch mental health care for clinical admissions. One of the goals is to keep the admission short. For some patients, this goal is not realized, which results in a long-term admission. Often, this is experienced as a disruption. Disruptions in care processes are frequently defined in terms of patient characteristics. Yet, it may be that other factors play a role. The aim of this study is to gain better insight into the perceptions of care professionals of what is characteristic for disruptions at High and Intensive Care wards and how professionals can deal with these. Qualitative research was performed by means of semi-structured interviews and a focus group with professionals. Results show that a focus on patient characteristics is too narrow and that other factors also play an important role. These factors include challenges in the relation between professionals and the patient, a divided team, and a lack of collaboration with ambulatory care. In order to deal with these factors, professionals should invest in the relationship with the patient, identify destructive team processes early, and improve communication with ambulatory care. It is recommended to develop a monitoring tool that includes all these factors. Another recommendation is to organize structured reflection on dilemmas experienced in care. In conclusion, this study shows the importance of going beyond patient characteristics in order to better understand, identify, and deal with disruption at High and Intensive Care wards

The Social Aspects in Water Management of Semarang’s Drainage System (Case Study of Banger Polder and Water Board BPP Sima)

The climate is changing, rainfall will increase, the sea level is rising and the river dischargeswill change more. Delta areas are faced with the increasing risk of flooding. A traditional solutionagainst flooding is the Dutch polder system. These polder areas in the Netherlands are for many yearsmanaged and maintained by water boards. The Dutch water board model has not been used much inother countries. At this moment it is not known what the social aspects of water management are,which are important in the implementation of a polder system and institute in another cultural contextoutside the Netherlands. For this research, the Banger Polder pilot Project in Semarang is used as acase study, where a polder is constructed and the first public organization for water management inIndonesia has been established. The new water board named BPP SIMA, is similar to the Dutch waterboard model and is responsible for creating and maintain of dry feet in the area. The water boardshould work with the stakeholders to know what the important aspects of the social side in watermanagement are.This research looked at the available knowledge by the selected stakeholders, the acceptance ofthe water fee and the main interest of the selected stakeholders in the Banger polder . The method thatis developed in this research gives insights of the social aspects in water management. The focus ofthis research is on the social dimension of water management. The developed method is the existingthree layer model of water governance in combination with a 360 degrees evaluation. The three layermodel is a method to analyze the risks and opportunities within the water management. The three layermodel consist of three layers, content layer, institutional layer and relational layer. This requiresdifferent information which are collected by existing literature, field visits, discussions, surveys andinterviews.In the survey results appears that not all local stakeholders are familiar with the project and BPPSIMA. This is because the communication with the existing hierarchical structure between RW/RTand inhabitants about the knowledge transfer of the project is lacking. According to existing literaturein this research, it is important that inhabitants feel involved and feel ownership of the project toincrease the acceptance of the water fee. They are the most important stakeholders and must feelinvolved with the water management. Inhabitants need knowledge about water problems to accept thepolicy and measures are implemented more efficient.Keywords: social aspects, water managemen

Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation

In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immunotherapeutic target in AML

Age-related curves of AMH using the Gen II, the picoAMH and the Elecsys assays in women with polycystic ovary syndrome

CONTEXT: Several challenges still exist to adopt the anti-Müllerian hormone (AMH) as a marker of polycystic ovary morphology (PCOM), as included in the recently updated international guideline. Although different evaluations of age- and assay-specific reference ranges have been published in the last years, these studies have mainly been conducted in normo-ovulatory or infertile women.OBJECTIVE: To develop an age-specific percentile distribution of AMH in patients with polycystic ovary syndrome (PCOS) measured by three different assays.DESIGN: Retrospective cross-sectional study.PATIENTS: 2,725 women aged 20 to 40 years with PCOS diagnosis were included.INTERVENTION (S): Serum AMH measurement by the Gen II (Beckman Coulter), the picoAMH (Ansh Labs), and the Elecsys (Roche) assays.MAIN OUTCOME MEAUSRE (S): Age-specific centile curves for all the assays and correlations between AMH, clinical, hormonal, and ultrasound characteristics.RESULTS: Age-related nomograms for the 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles of AMH were calculated using the LMS method for all the assays. AMH levels were significantly different between PCOS phenotypes. AMH levels were positive correlated to luteinizing hormone (LH), LH/follicular stimulating hormone (FSH) ratio, testosterone, androstenedione, free androgen index, mean follicular number, and mean ovarian volume.CONCLUSIONS: To our knowledge this is the first study reporting age specific percentile nomograms of serum AMH levels measured by the Gen II, the picoAMH and the Elecsys assays in a large population of PCOS women. These findings may help to interpret AMH levels in PCOS patients and facilitate the use of AMH as a diagnostic tool across age ranges.</p