70 research outputs found
An integrated approach to supply chain risk analysis
Despite the increasing attention that supply chain risk management is receiving by both researchers and practitioners, companies still lack a risk culture. Moreover, risk management approaches are either too general or require pieces of information not regularly recorded by organisations. This work develops a risk identification and analysis methodology that integrates widely adopted supply chain and risk management tools. In particular, process analysis is performed by means of the standard framework provided by the Supply Chain Operations Reference Model, the risk identification and analysis tasks are accomplished by applying the Risk Breakdown Structure and the Risk Breakdown Matrix, and the effects of risk occurrence on activities are assessed by indicators that are already measured by companies in order to monitor their performances. In such a way, the framework contributes to increase companies' awareness and communication about risk, which are essential components of the management of modern supply chains. A base case has been developed by applying the proposed approach to a hypothetical manufacturing supply chain. An in-depth validation will be carried out to improve the methodology and further demonstrate its benefits and limitations. Future research will extend the framework to include the understanding of the multiple effects of risky events on different processe
Tumor infiltrating effector memory Antigen-Specific CD8+ T Cells predict response to immune checkpoint therapy
Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. We tracked tumor antigen-specific CTL frequencies and phenotype before and after ICT in responding and non-responding animals. Tumor antigen-specific CTLs increased within tumor and draining lymph nodes after ICT, and exhibited an effector memory-like phenotype, expressing IL-7R (CD127), KLRG1, T-bet, and granzyme B. Responding tumors exhibited higher infiltration of effector memory tumor antigen-specific CTLs, but lower frequencies of regulatory T cells compared to non-responders. Tumor antigen-specific CTLs persisted in responding animals and formed memory responses against tumor antigens. Our results suggest that increased effector memory tumor antigen-specific CTLs, in the presence of reduced immunosuppression within tumors is part of a successful ICT response. Temporal and nuanced analysis of T cell subsets provides a potential new source of immune based biomarkers for response to ICT
Scintillation Counters for the D0 Muon Upgrade
We present the results of an upgrade to the D0 muon system. Scintillating
counters have been added to the existing central D0 muon system to provide
rejection for cosmic ray muons and out-of-time background, and to provide
additional fast timing information for muons in an upgraded Tevatron.
Performance and results from the 1994-1996 Tevatron run are presented.Comment: 30 pages, 25 postscript figure
Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV
We report the results of a study of color coherence effects in ppbar
collisions based on data collected by the D0 detector during the 1994-1995 run
of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8
TeV. Initial-to-final state color interference effects are studied by examining
particle distribution patterns in events with a W boson and at least one jet.
The data are compared to Monte Carlo simulations with different color coherence
implementations and to an analytic modified-leading-logarithm perturbative
calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters
Search for electroweak production of single top quarks in collisions.
We present a search for electroweak production of single top quarks in the electron+jets and muon+jets decay channels. The measurements use ~90 pb^-1 of data from Run 1 of the Fermilab Tevatron collider, collected at 1.8 TeV with the DZero detector between 1992 and 1995. We use events that include a tagging muon, implying the presence of a b jet, to set an upper limit at the 95% confidence level on the cross section for the s-channel process ppbar->tb+X of 39 pb. The upper limit for the t-channel process ppbar->tqb+X is 58 pb. (arXiv
Helicity of the W Boson in Lepton+Jets ttbar Events
We examine properties of ttbar candidates events in lepton+jets final states
to establish the helicities of the W bosons in t->W+b decays. Our analysis is
based on a direct calculation of a probability that each event corresponds to a
ttbar final state, as a function of the helicity of the W boson. We use the 125
events/pb sample of data collected by the DO experiment during Run I of the
Fermilab Tevatron collider at sqrt{s}=1.8 TeV, and obtain a longitudinal
helicity fraction of F_0=0.56+/-0.31, which is consistent with the prediction
of F_0=0.70 from the standard model
Hard Single Diffraction in pbarp Collisions at root-s = 630 and 1800 GeV
Using the D0 detector, we have studied events produced in proton-antiproton
collisions that contain large forward regions with very little energy
deposition (``rapidity gaps'') and concurrent jet production at center-of-mass
energies of root-s = 630 and 1800 Gev. The fractions of forward and central jet
events associated with such rapidity gaps are measured and compared to
predictions from Monte Carlo models. For hard diffractive candidate events, we
use the calorimeter to extract the fractional momentum loss of the scattered
protons.Comment: 11 pages 4 figures. submitted to PR
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