The effectiveness of the use of purified bacterial lysates of the most therapy-resistant strains of microorganisms – the causative agents of pustular skin infections in the treatment of acne vulgaris (acne vulgaris)

The objective of the work was to study the effectiveness of the use of purified bacterial lysates of the most therapy-resistant strains of microorganisms, the causative agents of pustular skin infections, by comparing clinical data and the skin microbiome in patients with acne. The results of the study are based on the data of a comprehensive examination of 35 patients with acne of 2-3 degrees before and after treatment, as well as data of the examination of 15 patients of the control group. Examination methods: clinical examination of the skin, determination of the quantitative composition and microbiological identification of the skin microbiome (bacteria of the genera Staphylococcus, Streptococcus, Propionibacterium Corynebacterium, Micrococcus, Sarcina, Aerococcus, Acinetobacter, Brevibacterium, Citrobacter, Serratia, Lactobacillus; yeast-like fungi of the genera Malassesia and Candida, mold fungi ). In the studied patients with acne, the representative microorganisms of the skin microbiome were Propionibacterium acnes, S. epidermidis, and C. lipophilicum. In patients with acne, the stability of the skin microbiome was carried out due to the redistribution between S. epidermidis and C. lipophilicum. In patients receiving "Acnevac"® (Bioveta, a. s.), a component of a complex treatment, along with earlier periods of clinical improvement, there was noted an earlier normalization of the skin microbiome in comparison with patients receiving standard therapy. Approaches to the treatment of acne with antibiotics and chemotherapy require a revision. The state of the skin microbiome broadens knowledge on the pathogenesis of acne and the search for other means for the individual treatment of patients. Positive changes in the skin microbiome under the influence of treatment with purified bacterial lysates of the most therapy-resistant strains of microorganisms, the causative agents of pustular skin infections, make it possible to recommend its use for a longer term – up to 6 months

Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET

The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR

Relationship of edge localized mode burst times with divertor flux loop signal phase in JET

A phase relationship is identified between sequential edge localized modes (ELMs) occurrence times in a set of H-mode tokamak plasmas to the voltage measured in full flux azimuthal loops in the divertor region. We focus on plasmas in the Joint European Torus where a steady H-mode is sustained over several seconds, during which ELMs are observed in the Be II emission at the divertor. The ELMs analysed arise from intrinsic ELMing, in that there is no deliberate intent to control the ELMing process by external means. We use ELM timings derived from the Be II signal to perform direct time domain analysis of the full flux loop VLD2 and VLD3 signals, which provide a high cadence global measurement proportional to the voltage induced by changes in poloidal magnetic flux. Specifically, we examine how the time interval between pairs of successive ELMs is linked to the time-evolving phase of the full flux loop signals. Each ELM produces a clear early pulse in the full flux loop signals, whose peak time is used to condition our analysis. The arrival time of the following ELM, relative to this pulse, is found to fall into one of two categories: (i) prompt ELMs, which are directly paced by the initial response seen in the flux loop signals; and (ii) all other ELMs, which occur after the initial response of the full flux loop signals has decayed in amplitude. The times at which ELMs in category (ii) occur, relative to the first ELM of the pair, are clustered at times when the instantaneous phase of the full flux loop signal is close to its value at the time of the first ELM

Cyclization processes in the fragmentation of the molecular ions of N-(aza-9-fluorenylidene)amines

The dissociative ionization of 17 Schiff bases obtained from 2(4)-azafluorenones and linear benzo-1,4-diazafluorenone was investigated. The intensities of the [M-H]+ and [M-CH3]1 ion peaks depend on the structures of the ketone and imine parts of the molecules and are determined by the possibility of the occurrence of cyclization processes with the participation of their structural elements. The fragmentation of the investigated azomethines is also accompanied by the elimination of an NR particle and a hydrocarbon R radical by the molecular ions. This process takes place most easily when a cyclohexyl substituent is present in the imine fragment. In contrast to previously investigated azomethines, the loss of an HCN molecule by the M+ ion occurs without participation of the exocyclic nitrogen atom. © 1981 Plenum Publishing Corporation

Mass-spectrometric study of methyl-substituted azomethines of the 4-azafluorene series

The M+ and [M-H]+ ion peaks are the peaks of maximum intensity in the mass spectra of Schiff bases belonging to the 4-aza-9-fluorenylidenearylamine series. The dependence of the relative intensity of the [M-H]+ fragment on the structures of the I-XI molecules provides evidence for the possibility of the occurrence of rearrangement processes involving the formation of this ion. The formation of [M-CH3]+, [M-HCN]+, [M-Ar]+, and [M-CNAr]+ ions is also characteristic for the fragmentation of the investigated compounds. It was found that, in contrast to other types of Schiff bases, the ejection of an HCN molecule during the mass-spectrometric fragmentation of the investigated compounds occurs without participation of the nitrogen atom of the azomethine group. The elimination of a CNAr particle by the molecular ions is a distinctive feature of the investigated series of Schiff bases. © 1979 Plenum Publishing Corporation